Annual incidence and mortality of bullous pemphigoid in the Grampian Region of North-east Scotland

Gudi, V.; White, Marion I.; Cruickshank, N; Herriot, Richard; Edwards, Simon; Nimmo, Fiona; Ormerod, Anthony

doi:10.1111/j.1365-2133.2005.06662.x

Cited by 137 publications

(164 citation statements)

References 21 publications

Supporting

Mentioning

131

Contrasting

Unclassified

Order By: Relevance

“…The annual incidence of BP calculated from our database was 3.4 per 100 000 population, which is consistent with the previously reported incidence rate, ranging from 0.7 to 4.3 per 100 000 per year. 1,[21][22][23] According to the literature, patients diagnosed with BP are more likely to have a history of cerebral stroke, ranging from 7.7% to 19.1%. 12,24 -26 To avoid any confusion caused by pre-existing cerebrovascular disease, patients with a history of any type of stroke before the onset of BP were excluded from this study.…”

Section: Discussionmentioning

confidence: 99%

Increased Risk of Stroke in Patients With Bullous Pemphigoid

Yang

Chen

Xirasagar

et al. 2011

Stroke

View full text Add to dashboard Cite

Background and Purpose-Although previous research reveals that cardiovascular events and thromboembolic diseases are important causes of death in patients with bullous pemphigoid (BP), the risk of stroke after the diagnosis of BP relative to the general population remains unknown. Using a randomly selected nationwide population-based sample, this study investigates the risk of stroke in patients with BP compared with unaffected individuals of a similar age. Methods-This study analyzes data from Taiwan's National Health Insurance Research Database. This sample included 390 patients with BP and 1950 matched subjects as a comparison group. Stratified Cox proportional hazard regressions were used to calculate the 3-year stroke risk for these 2 groups after adjusting for patient's age, sex, and comorbid medical disorders at baseline. Results-Of the 2340 patients in the sample, 312 patients (13.3%) had strokes during the 3-year follow-up period, 89(22.8% of the patients with BP) in the study group and 223 (11.4% of patients without BP) in the comparison group (PϽ0.001). The hazard ratio for stroke for patients with BP was 2.37 (95% CI, 1.78 to 3.15; PϽ0.001) times as high that for patients without BP within the 3-year follow-up period after adjusting for hypertension, diabetes, hyperlipidemia, heart failure, atrial fibrillation, and coronary heart disease. Conclusions-Patients

show abstract

Section: Discussionmentioning

confidence: 99%

Increased Risk of Stroke in Patients With Bullous Pemphigoid

Yang

Chen

Xirasagar

et al. 2011

Stroke

View full text Add to dashboard Cite

show abstract

“…In recent studies, the incidence of BP has been estimated to be between 7 and 42.8 new cases per million people per year [1,2,6,7,8,9,10,11,12]. A recent national prospective study has estimated the annual incidence of BP to be 12.1 new cases per million people in Switzerland [13].…”

Section: Introductionmentioning

confidence: 99%

Mortality Rate in Bullous Pemphigoid: A Retrospective Monocentric Cohort Study

et al. 2012

View full text Add to dashboard Cite

Background: Bullous pemphigoid (BP) is the most common autoimmune blistering skin disease and is associated with an increased mortality. The end points of our study were to evaluate the mortality rate in a retrospective cohort of BP patients followed up to 5 years after the diagnosis and to determine prognostics factors. Methods: All new cases of BP diagnosed between 1990 and 2003 in the University Hospital of Geneva were retrospectively collected. 60 patients were included, 47 (88.6%) of whom were treated with a combination of corticosteroids and chlorambucil. Results: The 1-year, 2-year and 5-year probabilities of death were 26.7, 37.1 and 60.8%, respectively. Old age, dementia and use of chlorambucil at initial doses of 6 mg/day, but not at lower doses, were associated with poor prognosis in multivariate analysis. Conclusion: Our study confirms that BP is associated with a high mortality. The observed mortality rates are however higher than those of previous studies, which is probably related to the inclusion of more debilitated patients.

show abstract

“…ullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease (1,2). Circulating autoantibodies target human type XVII collagen (human collagen 17 [hCOL17]), also known as BP Ag 2 (BPAG2) or BP180, which is a major component in hemidesmosome-anchoring filament complexes at the epidermal basement membrane zone (BMZ) (3)(4)(5)(6)(7)(8)(9).…”

mentioning

confidence: 99%