Annual health care costs among Medicare Beneficiaries with essential tremor

Kapinos, Kandice A.; Louis, Elan D.

doi:10.1016/j.parkreldis.2022.09.015

Cited by 10 publications

(8 citation statements)

References 13 publications

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“…2 ET patients are ubiquitous, deriving their care broadly from a variety of providers, ranging from general practitioners to movement disorders neurologists. 3 The medical costs associated with this disease are not trivial; a recent analysis predicted that, across the population, aggregated additional spending attributable to ET among Medicare beneficiaries was between $1.5 and $5.4 billion per year. 3 Despite its high prevalence, the ability to diagnose ET is to some degree problematic.…”

Section: Introductionmentioning

confidence: 99%

“…3 The medical costs associated with this disease are not trivial; a recent analysis predicted that, across the population, aggregated additional spending attributable to ET among Medicare beneficiaries was between $1.5 and $5.4 billion per year. 3 Despite its high prevalence, the ability to diagnose ET is to some degree problematic. In the absence of radiographic or tissue-based diagnostic markers, the diagnosis can only be made clinically-that is, based on the neurological history and examination.…”

Section: Introductionmentioning

confidence: 99%

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Pathologically based criteria to distinguish essential tremor from controls: analyses of the human cerebellum

Faust,

McCreary,

Musacchio

et al. 2024

Ann Clin Transl Neurol

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ObjectiveEssential tremor is among the most prevalent neurological diseases. Diagnosis is based entirely on neurological evaluation. Historically, there were few postmortem brain studies, hindering attempts to develop pathologically based criteria to distinguish essential tremor from control brains. However, an intensive effort to bank essential tremor brains over recent years has resulted in postmortem studies involving >200 brains, which have identified numerous degenerative changes in the essential tremor cerebellar cortex. Although essential tremor and controls have been compared with respect to individual metrics of pathology, there has been no overarching analysis to derive a combination of metrics to distinguish essential tremor from controls. We asked whether there is a constellation of pathological findings that separates essential tremor from controls, and how well that constellation performs.MethodsAnalyses included 100 essential tremor brains from the essential tremor centralized brain repository and 50 control brains. A standard tissue block from the cerebellar cortex was used to quantify 11 metrics of pathological change. Three supervised classification algorithms were investigated, with data divided into training and validation samples.ResultsUsing three different algorithms, we illustrate the ability to correctly predict a diagnosis of essential tremor, with sensitivity and specificity >87%, and in the majority of situations, >90%. We also provide a web‐based application that uses these metric values, and based on specified cutoffs, determines the likely diagnosis.InterpretationThese analyses set the stage for use of pathologically based criteria to distinguish clinically diagnosed essential tremor cases from controls, at the time of postmortem.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pathologically based criteria to distinguish essential tremor from controls: analyses of the human cerebellum

Faust,

McCreary,

Musacchio

et al. 2024

Ann Clin Transl Neurol

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“…1 In addition to diminishing the quality of life of millions of patients, ET exacts significant economic costs at the individual and societal levels. 2 Following a landmark multicenter randomized trial that noninvasively targeted the nucleus ventralis intermedius (VIM) using transcranial MRguided focused ultrasound (MRgFUS), 3 the first MRgFUS device was approved in 2016 for clinical treatment of medically refractory and disabling ET. However, to date, both the etiology of ET and the underlying mechanism through which MRgFUS of the VIM enables tremor suppression are still not well understood.…”

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confidence: 99%

“…A recent analysis of studies from 23 countries determined that ET has a prevalence of about 6% in the population aged 65 years and above 1 . In addition to diminishing the quality of life of millions of patients, ET exacts significant economic costs at the individual and societal levels 2 . Following a landmark multicenter randomized trial that noninvasively targeted the nucleus ventralis intermedius (VIM) using transcranial MR‐guided focused ultrasound (MRgFUS), 3 the first MRgFUS device was approved in 2016 for clinical treatment of medically refractory and disabling ET.…”

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confidence: 99%

Editorial for “Alteration of White Matter Connectivity for MR‐Guided Focused Ultrasound in the Treatment of Essential Tremor”

Yeo

2023

Magnetic Resonance Imaging

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“…A recent health economics study estimated that, across the population, aggregated additional spending attributable to ET among Medicare beneficiaries was between $1.5 billion and $5.4 billion per year. 9 Research such as that presented by Dai et al 1 begins to provide insights into the potential sources of such spending. Email address: elan.louis@UTSouthwestern.edu…”

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confidence: 99%