Annonamine, a New Aporphine Alkaloid from the Leaves of Annona muricata

Abstract

Atypical Parkinsonism in the Caribbean Island Guadeloupe is thought to be associated with the consumption of plants of the Annonaceae family, especially Annona muricata (soursop). In this study, a new aporphine alkaloid named annonamine (1) was isolated from the leaves of A. muricata L. together with four known benzylisoquinoline alkaloids (2-5). The structures of the isolated compounds were elucidated by the spectroscopic method.

Enhanced Harnessing of the Graviola Bioactive Components Using a Neoteric Sonication Cum Microwave Coadjuvant Extraction Protocol

“…As revealed from the earlier results pertaining to the total phenolics, flavonoids and antioxidant activity, where SMW-WE, CB-WE, MW-WE recorded higher values, these UV results also confirm that enhanced extraction was enabled by these methodologies compared to PB-WE and S-WE methods. The fruits, leaves, stems and roots of Graviola are known to be rich in flavonoids, isoquinoline alkaloids and annonaceous acetogenins [2,[33][34][35][36][37][38][39][40]. It is reported [41,42] that absorption peaks from 200 to 230 nm are characteristic of acetogenins.…”

Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compounds

“…The phenolic compounds identified accounted for 56.43 mg/g of dry extract (Table 1). According to Matsushige et al, (2012a) and Leboeuf et al, (1981), leaves are also a source of alkaloids such as annonamine, anonaine, (1), 137(1)) were detected (Stévigny et al, 2004;Schmidt et al, 2005;Rottscholl et al, 2016) (Fig. 1B, supplementary data, section S2, Fig.…”

“…The absence of almost all previously reported alkaloids may be related with the extraction procedure employed in the current study. Indeed, Matsushige et al, (2012a) extracted the alkaloid fraction with MeOH followed by partitioning with n-hexane, chloroform, ethyl acetate and buthanol successively. Acetogenins are usually regarded as lipophilic neurotoxins (Caparros-Lefebvre et al, 1999;Champy et al, 2005).…”

Determination and Modeling of Thermophysical and Transport Properties of Tropical Pulps

“…This scenery expands the economy and creates new paths for the formulation of new products and co-products in the food industry. Amongst the exotic regional species of fruits in Brazil, special attention has been given to Hancornia speciosa G. ("mangaba"), Annona muricata L. ("graviola") and Eugenia uniflora Berg ("pitanga") due to their high nutritional value, aromatic and economic regional importance [19][20][21][22][23][24][25][26][27][28][29][30]. The characterization, and the comprehension of the thermophysical and transport properties of these foods are necessary to their effective use in the commercial scale.…”