Annona cherimola Miller and Its Flavonoids, an Important Source of Products for the Treatment of Diabetes Mellitus: In Vivo and In Silico Evaluations

Calzada, Fernando; Valdés, Miguel Ángel Serra; Martínez-Solís, Jesús; Velázquez, Claudia; Barbosa, Elizabeth

doi:10.3390/ph16050724

Cited by 3 publications

(2 citation statements)

References 44 publications

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“…Myricetin not only possesses pharmacological properties including anti-inflammatory, antitumor, antimutagenic and cariostatic effects as well as antioxidative and free radical scavenging activities but also exerts its maximum effect through glucose inhibition [49,50]. In vitro studies have demonstrated that myricetin reduces blood glucose levels by increasing myocyte uptake and glycogen synthesis [51,52].…”

Section: The Monomeric Constituents Of Lotus Leaf Associated With Obe...mentioning

confidence: 99%

Exploring the Potential of Lotus Leaf and Its Bioactive Compounds for Anti-obesity Interventions

Chen,

Zhang,

Zhang

et al. 2024

J. Exp. Clin. Appl. Chin. Med

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The complex syndrome of obesity is a complex syndrome associated with various metabolic disorders, poses significant threats to human health. Many weight loss medications have the potential to rapidly treat obesity, however their toxicity and adverse effects may compromise patients' physiological and psychological well-being. In China, the concept of drug and food homology has been utilized for thousands of years, with lotus leaves serving as a representative example. The lotus leaves have been traditionally used for heat-clearing and lipid-lowering purposes, as well as for cooling the blood and promoting hemostasis, since ancient times. This review represents the first attempt to qualitatively investigate the anti-obesity properties of lotus leaves by integrating gene-disease association databases and drug-target databases for analysis. Additionally, it summarizes the identified monomers in lotus leaves that have been reported to possess functions associated with anti-obesity. The aim of this study is to provide a comprehensive review of the research progress on anti-obesity drugs derived from lotus leaves, and to facilitate further research and development in the field of anti-obesity medication targeting adiposity.

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Section: The Monomeric Constituents Of Lotus Leaf Associated With Obe...mentioning

confidence: 99%

Exploring the Potential of Lotus Leaf and Its Bioactive Compounds for Anti-obesity Interventions

Chen,

Zhang,

Zhang

et al. 2024

J. Exp. Clin. Appl. Chin. Med

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“…Several recent studies showed that different parts of cherimoya (especially fruit and leaves) possess an interesting phytochemical profile, are rich in polyphenols and alkaloids [ 17 ], and are valuable sources of active ingredients for traditional medicine preparation for the treatment of gastric, intestinal, cardiovascular, skin, and eye diseases [ 18 ]. According to recent research data, the extracts and active compounds obtained from A. cherimola possess antibacterial, antiviral, antidiabetic, anti-hyperlipidemic, and anticancer properties [ 19 , 20 ]. In modern cosmetics, Annona Cherimola Fruit Extract is used in cosmetic products as a skin-conditioning ingredient, and hydrolyzed Annona Cherimola fruit extract is applied as a skin-conditioning and antioxidant component of cosmetic formulations [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Pulp or Peel? Comparative Analysis of the Phytochemical Content and Selected Cosmetic-Related Properties of Annona cherimola L., Diospyros kaki Thumb., Cydonia oblonga Mill. and Fortunella margarita Swingle Pulp and Peel Extracts

Lasota,

Lechwar,

Kukula-Koch

et al. 2024

Molecules

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Fruit peels might be a valuable source of active ingredients for cosmetics, leading to more sustainable usage of plant by-products. The aim of the study was to evaluate the phytochemical content and selected biological properties of hydroglycolic extracts from peels and pulps of Annona cherimola, Diospyros kaki, Cydonia oblonga, and Fortunella margarita as potential cosmetic ingredients. Peel and pulp extracts were compared for their antiradical activity (using DPPH and ABTS radical scavenging assays), skin-lightening potential (tyrosinase inhibitory assay), sun protection factor (SPF), and cytotoxicity toward human fibroblast, keratinocyte, and melanoma cell lines. The total content of polyphenols and/or flavonoids was significantly higher in peel than in pulp extracts, and the composition of particular active compounds was also markedly different. The HPLC-MS fingerprinting revealed the presence of catechin, epicatechin and rutoside in the peel of D. kaki, whereas kaempferol glucoside and procyanidin A were present only in the pulp. In A. cherimola, catechin, epicatechin and rutoside were identified only in the peel of the fruit, whereas procyanidins were traced only in the pulp extracts. Quercetin and luteolinidin were found to be characteristic compounds of F. margarita peel extract. Naringenin and hesperidin were found only in the pulp of F. margarita. The most significant compositional variety between the peel and pulp extracts was observed for C. oblonga: Peel extracts contained a higher number of active components (e.g., vicenin-2, kaempferol rutinoside, or kaempferol galactoside) than pulp extract. The radical scavenging potential of peel extracts was higher than of the pulp extracts. D. kaki and F. margarita peel and pulp extracts inhibited mushroom and murine tyrosinases at comparable levels. The C. oblonga pulp extract was a more potent mushroom tyrosinase inhibitor than the peel extract. Peel extract of A. cherimola inhibited mushroom tyrosinase but activated the murine enzyme. F. margarita pulp and peel extracts showed the highest in vitro SPF. A. cherimola, D. kaki, and F. margarita extracts were not cytotoxic for fibroblasts and keratinocytes up to a concentration of 2% (v/v) and the peel extracts were cytotoxic for A375 melanoma cells. To summarize, peel extracts from all analyzed fruit showed comparable or better cosmetic-related properties than pulp extracts and might be considered multifunctional active ingredients of skin lightening, anti-aging, and protective cosmetics.

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Highly Soluble β-Glucan Fiber Modulates Mechanisms of Blood Glucose Regulation and Intestinal Permeability

Marcobal,

McConnell,

Drexler

et al. 2024

Nutrients

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β-glucans found in cereal grains have been previously demonstrated to improve blood glucose control; however, current understanding points to their high viscosity as the primary mechanism of action. In this work, we present a novel, highly soluble, low-viscosity β-glucan fiber (HS-BG fiber) and a preclinical dataset that demonstrates its impact on two mechanisms related to the prevention of hyperglycemia. Our results show that HS-BG inhibits the activity of two key proteins involved in glucose metabolism, the α-glucosidase enzyme and the SGLT1 transporter, thereby having the potential to slow starch digestion and subsequent glucose uptake. Furthermore, we demonstrate in a multi-donor fecal fermentation model that HS-BG is metabolized by several different members of the gut microbiome, producing high amounts of short-chain fatty acids (SCFAs), known agonists of GPR43 receptors in the gut related to GLP-1 secretion. The production of SCFAs was verified in the translational gut model, SHIME®. Moreover, HS-BG fiber fermentation produces compounds that restored permeability in disrupted epithelial cells, decreased inflammatory chemokines (CXCL10, MCP-1, and IL-8), and increased anti-inflammatory marker (IL-10), which could improve insulin resistance. Together, these data suggest that the novel HS-BG fiber is a promising new functional ingredient that can be used to modulate postprandial glycemic responses while the high solubility and low viscosity enable easy formulation in both beverage and solid food matrices.

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Annona cherimola Miller and Its Flavonoids, an Important Source of Products for the Treatment of Diabetes Mellitus: In Vivo and In Silico Evaluations

Cited by 3 publications

References 44 publications

Exploring the Potential of Lotus Leaf and Its Bioactive Compounds for Anti-obesity Interventions

Exploring the Potential of Lotus Leaf and Its Bioactive Compounds for Anti-obesity Interventions

Pulp or Peel? Comparative Analysis of the Phytochemical Content and Selected Cosmetic-Related Properties of Annona cherimola L., Diospyros kaki Thumb., Cydonia oblonga Mill. and Fortunella margarita Swingle Pulp and Peel Extracts

Highly Soluble β-Glucan Fiber Modulates Mechanisms of Blood Glucose Regulation and Intestinal Permeability

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