Abstract. The notion of derivatives for smooth representations of GL(n, Qp) was defined in [BZ77]. In the archimedean case, an analog of the highest derivative was defined for irreducible unitary representations in [Sah89] and called the "adduced" representation. In this paper we define derivatives of all orders for smooth admissible Fréchet representations (of moderate growth). The real case is more problematic than the p-adic case; for example arbitrary derivatives need not be admissible. However, the highest derivative continues being admissible, and for irreducible unitarizable representations coincides with the space of smooth vectors of the adduced representation.In [AGS] we prove exactness of the highest derivative functor, and compute highest derivatives of all monomial representations.We apply those results to finish the computation of adduced representations for all irreducible unitary representations and to prove uniqueness of degenerate Whittaker models for unitary representations, thus completing the results of [Sah89,Sah90,SaSt90,GS13a].