Annexin1 regulates the erythroid differentiation through ERK signaling pathway

Huo, Xiao; Zhang, Jun Wu

doi:10.1016/j.bbrc.2005.04.049

Cited by 19 publications

(18 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Annexin 1 (ANXA1) was reported to be critical to erythroid differentiation after showing that its knockdown in K562 cells decreased hemin-induced erythroid differentiation (20). However, in our study, ANXA1 is downregulated 20-fold during erythroid differentiation, suggesting its role may be limited to hemin-induced hemoglobinization of K562 cells.…”

Section: Comparison Of De List With Other Studies Of Erythroid Develocontrasting

confidence: 65%

Transcriptional regulatory network analysis of developing human erythroid progenitors reveals patterns of coregulation and potential transcriptional regulators

Keller¹,

Addya²,

Vadigepalli

et al. 2006

Physiological Genomics

View full text Add to dashboard Cite

We used an in vitro erythroid differentiation system to study the developing red blood cell transcriptome derived from adult CD34ϩ hematopoietic progenitor cells. mRNA expression profiling was used to characterize developing erythroid cells at six time points during differentiation (days 1, 3, 5, 7, 9, and 11). Eleven thousand seven hundred sixty-three genes (20,963 Affymetrix probe sets) were expressed on day 1, and 1,504 genes, represented by 1,953 probe sets, were differentially expressed (DE) with 537 upregulated and 969 downregulated. A subset of the DE genes was validated using realtime RT-PCR. The DE probe sets were subjected to a cluster metric and could be divided into two, three, four, five, or six clusters of genes with different expression patterns in each cluster. Genes in these clusters were examined for shared transcription factor binding sites (TFBS) in their promoters by comparing enrichment of each TFBS relative to a reference set using transcriptional regulatory network analysis. The sets of TFBS enriched in genes up-and downregulated during erythropoiesis were distinct. This analysis identified transcriptional regulators critical to erythroid development, factors recently found to play a role, as well as a new list of potential candidates, including Evi-1, a potential silencer of genes upregulated during erythropoiesis. Thus this transcriptional regulatory network analysis has yielded a focused set of factors and their target genes whose role in differentiation of the hematopoietic stem cell into distinct blood cell lineages can be elucidated.

show abstract

Section: Comparison Of De List With Other Studies Of Erythroid Develocontrasting

confidence: 65%

Transcriptional regulatory network analysis of developing human erythroid progenitors reveals patterns of coregulation and potential transcriptional regulators

Keller¹,

Addya²,

Vadigepalli

et al. 2006

Physiological Genomics

View full text Add to dashboard Cite

show abstract

“…18 In another study on erythroid differentiation it was found that the level of AnxA1 expression was notably increased during this process; a positive impact was established by knock down of AnxA1 with specific RNAi in K562 cell clone, which significantly blocked erythroid differentiation. 19 During the DN1 and DN2 stages of T cell development, thymocytes undergo proliferation to expand the thymocyte pool. 20 Thus, it is possible that high expression of AnxA1 at the DN1 stage might serve as a proliferative factor.…”

Section: Discussionmentioning

confidence: 99%

Role of endogenous Annexin-A1 in the regulation of thymocyte positive and negative selection

Paschalidis¹,

Huggins²,

Rowbotham³

et al. 2010

Cell Cycle

View full text Add to dashboard Cite

“…ANXA1 was initially identiWed as a phospholipase A2 inhibitor (Goulding et al 1990). Subsequent studies demonstrated that ANXA1 plays a critical role in a variety of cellular processes such as proliferation (Alldridge and Bryant 2003), diVerentiation (Huo and Zhang 2005;Solito et al 1998) and apoptosis (Solito et al 2003). Since signiWcant up-regulation of ANXA1 protein expression was observed in partially hepat- (de Coupade et al 2000) or pancreatectomized animals (Yang et al 2006), ANXA1 has generated interest for investigation in epithelial regeneration.…”

Section: Introductionmentioning

confidence: 96%

Down-regulation of plasma membranous Annexin A1 protein expression in premalignant and malignant lesions of the oral cavity: correlation with epithelial differentiation

Nomura

Uzawa

Yamano

et al. 2008

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

show abstract

Annexin1 regulates the erythroid differentiation through ERK signaling pathway

Cited by 19 publications

References 21 publications

Transcriptional regulatory network analysis of developing human erythroid progenitors reveals patterns of coregulation and potential transcriptional regulators

Transcriptional regulatory network analysis of developing human erythroid progenitors reveals patterns of coregulation and potential transcriptional regulators

Role of endogenous Annexin-A1 in the regulation of thymocyte positive and negative selection

Down-regulation of plasma membranous Annexin A1 protein expression in premalignant and malignant lesions of the oral cavity: correlation with epithelial differentiation

Contact Info

Product

Resources

About