Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair

Bouter, Anthony; Gounou, Céline; Bérat, Rémi; Tan, Sisareuth; Gallois, B.; Granier, T.; d’Estaintot, Béatrice Langlois; Pöschl, Ernst; Brachvogel, Bent; Brisson, Alain

doi:10.1038/ncomms1270

Cited by 251 publications

(307 citation statements)

References 59 publications

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“…24 Annexins A5 and A6 have also been implicated in the process of PMR. 51,53 The ability of ANXA5 to assemble into 2-dimensional arrays at the sites of membrane injury in response to Ca 2C has been implicated in preventing wound expansion by keeping the membrane edges together. This is prevented in cells lacking ANXA5 causing PMR defect.…”

mentioning

confidence: 99%

S100 and annexin proteins identify cell membrane damage as the Achilles heel of metastatic cancer cells

Jaiswal

Nylandsted

2015

Cell Cycle

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mentioning

confidence: 99%

S100 and annexin proteins identify cell membrane damage as the Achilles heel of metastatic cancer cells

Jaiswal

Nylandsted

2015

Cell Cycle

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“…ANXA5 was found to bind and form 2D arrays exclusively around the edges of the wound perimeter. Further, perivascular mouse cells deficient of ANXA5 exhibited a severe membrane repair defect that was rescued by the addition of exogenous recombinant ANXA5 protein [34] . The 2D ANXA5 array formed at the torn membrane is proposed to prevent wound expansion by restricting membrane tension and keeping the membrane edges together to promote resealing.…”

Section: Annexin and S100 Proteins In Membrane Repairmentioning

confidence: 99%

Plasma membrane repair provides a new strategy for targeting metastatic cancer cells

Nylandsted

2015

Can Cell Microenviron

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Stress induced plasma membrane injuries imposed by mechanical activity and the extracellular environment is a constant threat to cells that they need to cope with to stay alive. This is especially prominent for invasive cancer cells with their increased motility and capacity to navigate through the harsh tumor stroma, which further increases the risk of plasma membrane injury. The impact of these stresses on cancer cell membrane and mechanism by which tumor cells cope with this is poorly understood. Plasma membrane repair (PMR) is triggered by Ca 2+ influx through the injury site. Depending on the cell type and extent of damage, cells use different components including yolk granules, lysosomes, mitochondria and cytoskeleton to help repair the damaged plasma membrane. Here, the involvement of annexins and S100 proteins in PMR will be discussed in light of our recent discovery showing that metastatic cancer cells require S100A11 protein and its binding partner annexin A2 for PMR. This Ca 2+ -triggered protein complex facilitate resealing by modulating polymerization of actin cytoskeleton at the plasma membrane to enable wound closure and excision of damaged membrane. These findings demonstrate that cancer cells depend on efficient PMR, which reveal a new approach for targeting metastatic cancer cells.Keywords: Plasma Membrane Repair; Cancer; Annexins; S100 proteins; S100A11; Annexin A2; Metastasis; Breast Cancer; Actin To cite this article: Jesper Nylandsted. Plasma membrane repair provides a new strategy for targeting metastatic cancer cells.

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“…In vertebrates, annexins are known to display a broad range of biological activities including response to inflammation, membrane traffic and adhesion, anticoagulation, signal transduction, developmental processes and membrane repair (Bouter et al, 2011;Draeger et al, 2011). In parasites, annexins are suggested to be involved in maintenance of membrane structure (Peattie et al, 1989;Tararam et al, 2010), anti-inflammatory activity (Zhang et al, 2007) and fibrinolytic activity (de la Torre-Escudero et al, 2012).…”

Section: Annexins In Schistosomesmentioning

confidence: 99%

Structure–function analysis of apical membrane‐associated molecules of the tegument of schistosome parasites of humans: prospects for identification of novel targets for parasite control

Leow

Willis

Hofmann

et al. 2014

British J Pharmacology

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Neglected tropical diseases are a group of some 17 diseases that afflict poor and predominantly rural people in developing nations. One significant disease that contributes to substantial morbidity in endemic areas is schistosomiasis, caused by infection with one of five species of blood fluke belonging to the trematode genus Schistosoma. Although there is one drug available for treatment of affected individuals in clinics, or for mass administration in endemic regions, there is a need for new therapies. A prominent target organ of schistosomes, either for drug or vaccine development, is the peculiar epithelial syncytium that forms the body wall (tegument) of this parasite. This dynamic layer is maintained and organized by concerted activity of a range of proteins, among which are the abundant tegumentary annexins. In this review, we will outline advances in structure-function analyses of these annexins, as a means to understanding tegument cell biology in host-parasite interaction and their potential exploitation as targets for anti-schistosomiasis therapies. LINKED ARTICLESThis article is part of a themed section on Annexins VII Programme. To view the other articles in this section visit http://dx.doi. org/10.1111/bph.2015.172.issue-7 Abbreviations Anx, annexin; NTDs, neglected tropical diseases; RA, radiation attenuated; Sm, Schistosoma mansoni; TEMs, tetraspanin-enriched microdomains; TSP, tetraspanin Neglected tropical diseases (NTDs)NTDs include some 17 lesser known chronic infections that affect poor and disenfranchised people, primarily, but not exclusively, in developing nations (Hotez et al., 2007;Hotez and Fenwick, 2009). Chronic infections caused by NTDs lead to many adverse outcomes in affected populations and contribute substantially to human morbidity. In addition to microbial and protozoan diseases, NTDs include a number of helminth infections, such as diseases caused by flatworm parasites, notably schistosomiasis, echinococcosis and liver fluke diseases, as well as roundworm parasites, such as the major soil transmitted helminth infections (ascariasis, trichuriasis and hookworm diseases). Although no individual NTD rivals the major infectious threats of HIV, malaria or tuberculosis in terms of global impact of disease, collectively, the NTDs contribute substantially to morbidity throughout the world (Engels and Savioli, 2006). A number of factors present major challenges for the development of new treatments for NTDs. Firstly, NTDs are chronic diseases, which may reside in affected people as lifelong infections. Secondly, NTDs are not always associated with human mortality and the burden of these diseases can be subtle, hidden among such other measures of disease burden as hindered development, poor cognitive function and chronic ailments. Thirdly, as stated, NTDs often affect the poorest of the poor, people often unable to pay for medical treatments, especially for chronic illnesses. Hence, these diseases receive less attention than other, immediately lifethreatening infectious diseases. La...

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Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair

Cited by 251 publications

References 59 publications

S100 and annexin proteins identify cell membrane damage as the Achilles heel of metastatic cancer cells

S100 and annexin proteins identify cell membrane damage as the Achilles heel of metastatic cancer cells

Plasma membrane repair provides a new strategy for targeting metastatic cancer cells

Structure–function analysis of apical membrane‐associated molecules of the tegument of schistosome parasites of humans: prospects for identification of novel targets for parasite control

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