Annexin A1 subcellular expression in laryngeal squamous cell carcinoma

Alves, Venâncio Avancini Ferreira; Nonogaki, Suely; Cury, Patrí­cia Maluf; Wünsch-Filho, Victor; Carvalho, Marcos Brasilino de; Michaluart-Júnior, P; Moysés, Raquel Ajub; Curioni, Otávio Alberto; Figueiredo, David Livingstone Alves; Scapulatempo‐Neto, Cristovam; Parra, Edwin R.; Polachini, Giovana Mussi; Silistino-Souza, Rosana; Oliani, Sônia Maria; Silva, Israel Tojal da; Nóbrega, Francisco G.; Genome, Neck; Gencapo,; Tajara, Eloíza H.; Zago, Marco Antônio

doi:10.1111/j.1365-2559.2008.03186.x

Cited by 26 publications

(30 citation statements)

References 38 publications

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“…Moreover, kim et al proposed that PMA-induced translocation of annexin A1 to the nucleus may participate in the regulation of cell proliferation and differentiation (Kim et al, 2003). In addition, several studied have approved that nuclear translocation of annexin A1 is involved in the regulation of cellular proliferation (Alldridge & Bryant., 2003;Alves et al, 2008). Similarly, in our study, as the tumor tissues of PDAC patients with high expression of annexin A1 and weak nuclear staining showed worse prognosis and outcome, we hypothesisd that annexin A1 translocated to the nuclei may be involved in the different processes in both cytoplasm and nuclei including specific cellular functions as well as signal transduction and the regulatory effects of annexin A1 may involve both transcriptional and translational levels.…”

Section: 4707 Prognostic Significance Of Annexin A1 Expression In Pasupporting

confidence: 72%

Prognostic Significance of Annexin A1 Expression in Pancreatic Ductal Adenocarcinoma

Chen¹,

Shen²,

Wang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Annexin A1 is a 37-kDa calcium-and phospholipid-binding protein of the annexin superfamily considered to play an important role in tumorigenesis. However, associations with clinicopathological features in pancreatic ductal adenocarcinoma (PDAC) cases have yet to be fully defined. We therefore investigated the prognostic value of annexin A1 protein as a PDAC biomarker in 83 tumor and matched non-cancerous tissues or normal pancreas tissues. Expression was analyzed using real-time RT-PCR, Western blotting and immunohistochemistry. In non-tumor tissue, myoepithelial cells showed no or weak expression of annexin A1 while expression was strong and sometimes even located in the nuclei of endothelial cells in tumor tissue. High expression was significantly associated with advanced stage (P <0.05) and a worse overall survival (P <0.05). These results provide new insights to better understand the role of annexin A1 in PDAC survival, and might be relevant to prediction of prognosis and development of more effective therapeutic strategies aimed at improving survival.

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Section: 4707 Prognostic Significance Of Annexin A1 Expression In Pasupporting

confidence: 72%

Prognostic Significance of Annexin A1 Expression in Pancreatic Ductal Adenocarcinoma

Chen¹,

Shen²,

Wang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…However, different members of the Annexin family proteins are either up-or downregulated in cancer tissue, so different Annexins may perform different roles in specific types of cancer (5,6). It has been demonstrated that Annexin A1 is associated with esophageal cancer and is overexpressed in laryngeal carcinoma cells; it may therefore progressively migrate from the nucleus towards the membrane during laryngeal tumorigenesis (7). By contrast, Annexin A2 is associated with breast cancer (8) and knockdown of Annexin A2 by RNA interference decreases the proliferation and invasion of breast cancer cells (9).…”

Section: Introductionmentioning

confidence: 99%

Annexin A2 is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer

Luo

Xie

et al. 2017

Exp Ther Med

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Abstract. Due to the lack of a definite diagnosis, a frequent recurrence rate and resistance to chemotherapy or radiotherapy, the clinical outcome for patients with advanced laryngeal cancer has not improved over the last decade. Annexin A2 is associated with the invasion and metastasis of cancer cells. In the present study, it was demonstrated using differential proteomics analysis that Annexin A2 is highly expressed in laryngeal carcinoma tissues and this was confirmed using immunohistochemistry, which demonstrated that the expression of Annexin A2 in laryngeal carcinoma tissues was significantly higher than in healthy adjacent tissue. In addition, its potential predictive value in the prognosis of patients with laryngeal carcinoma was evaluated. The results demonstrated that Annexin A2 expression was significantly associated with tumor size, lymph node metastasis, distant metastasis and clinical stage. In addition, higher Annexin A2 expression was associated with a poor prognosis of patients with laryngeal cancer. Thus, the results of the present study indicate that Annexin A2 expression is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer.

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“…In tumors of the head and neck area, studies have been done evaluating the role carcinomas of the head and neck and revealing a relationship between this reduction and a lack of differentiation in the tumors [42][43][44][45]. To the best of our knowledge, the present study is the first to evaluate the expression of ANXA1 in association with HPV infection in oropharyngeal cancer, thereby demonstrating a relationship between two important and current markers for this disease.…”

Section: Discussionmentioning

confidence: 96%

Relationship between HPV and biomarkers annexin A1 and P53 in oropharyngeal cancer

et al. 2014

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Background: Human papillomavirus (HPV) is often present in oropharyngeal cancers. Head and neck tumors have been examined for other molecular markers including p53 and annexin A1 (ANXA1). Here, we investigated the prevalence of HPV and its relationship with p53 and ANXA1 in patients with oropharyngeal cancer. Methods: We have analyzed tumor and adjacent mucosa from 22 patients with squamous cell carcinoma of the oropharynx in addition to samples of the oropharyngeal epithelium in subjects without cancer. We evaluated the presence of the HPV (subtypes 16/18 and 31/33) by chromogenic in situ hybridization. Additionally, we used immunofluorescence to examine the expression of p16, p53, ANXA1 and the phosphorylation of the ANXA1 residues Ser27 (ANXA1-SER) and Tyr21 (ANXA1-TYR).

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Annexin A1 subcellular expression in laryngeal squamous cell carcinoma

Abstract: ANXA1 dysregulation was observed early in laryngeal carcinogenesis, in intra-epithelial neoplasms; it was not found related to prognostic parameters, such as nodal metastases.

Cited by 26 publications

References 38 publications

Prognostic Significance of Annexin A1 Expression in Pancreatic Ductal Adenocarcinoma

Prognostic Significance of Annexin A1 Expression in Pancreatic Ductal Adenocarcinoma

Annexin A2 is an independent prognostic biomarker for evaluating the malignant progression of laryngeal cancer

Relationship between HPV and biomarkers annexin A1 and P53 in oropharyngeal cancer

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