Annexin A1 peptide and endothelial cell‐conditioned medium modulate cervical tumorigenesis

Cardin, Laila Toniol; Prates, Janesly; Cunha, Bianca Rodrigues da; Tajara, Eloíza H.; Oliani, Sônia Maria; Rodrigues-Lisoni, Flávia Cristina

doi:10.1002/2211-5463.12603

Cited by 9 publications

(5 citation statements)

References 60 publications

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“…In order to better understand the mechanisms of cancer progression, some mediators (PTGS2 and PTGER4), which have been extensively studied by our research group previously, have been verified [ 34 , 35 ]. In addition, tumorigenic cells have a characteristic of uncontrolled growth, and it is known that as arachidonic acid derivatives participate in inflammation and are also closely linked to tumor development, with PTGS2 being highly expressed in hyperplastic tissues, the study of the genes of this inflammatory pathway is necessary in head and neck cancer [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer

Gusson-Zanetoni,

Cardoso,

de Sousa

et al. 2024

IJMS

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Piperine, an active plant alkaloid from black pepper (Piper nigrum), has several pharmacological effects, namely antioxidant, anti-inflammatory and immunomodulatory effects, which involve inhibiting molecular events associated with various stages of cancer development. The aim of this study was to investigate the molecular mechanisms of action of piperine in relation to its potential anticancer effect on head and neck cancer cells. Parameters related to neoplastic potential and cytokine, protein and gene expression were investigated in head and neck cancer cell lines (HEp-2 and SCC-25) treated with piperine. The results of the tests indicated that piperine modified morphology and inhibited viability and the formation of cell colonies. Piperine promoted genotoxicity by triggering apoptosis and cell cycle arrest in the G2/M and S phases. A decrease in cell migration was also observed, and there was decreased expression of MMP2/9 genes. Piperine also reduced the expression of inflammatory molecules (PTGS2 and PTGER4), regulated the secretion of cytokines (IFN-γ and IL-8) and modulated the expression of ERK and p38. These results suggest that piperine exerts anticancer effects on tumor cells by regulating signaling pathways associated with head and neck cancer.

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Section: Discussionmentioning

confidence: 99%

Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer

Gusson-Zanetoni,

Cardoso,

de Sousa

et al. 2024

IJMS

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“…Furthermore, ANXA1 N-terminal mimetic peptide Ac 2–26 has been proposed as a potential therapeutic strategy for cancer treatment, targeting ANXA1-mediated functions and related signaling pathways. As a proof of principle, it has been demonstrated that Ac 2–26 is able to decrease the proliferation of cervical cancer cells, through the activation of the MAPK family and targeting p53 to arrest the cell cycle ( Cardin et al, 2019 ). It has also been showed that Ac 2–26 could be used to treat non-small cell lung cancer (NSCLC), regulating NFkB pathway ( Guan et al, 2019 ).…”

Section: Annexin A1mentioning

confidence: 99%

Pathobiological functions and clinical implications of annexin dysregulation in human cancers

Prieto-Fernández

Menéndez

Otero-Rosales

et al. 2022

Front. Cell Dev. Biol.

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Annexins are an extensive superfamily of structurally related calcium- and phospholipid-binding proteins, largely conserved and widely distributed among species. Twelve human annexins have been identified, referred to as Annexin A1-13 (A12 remains as of yet unassigned), whose genes are spread throughout the genome on eight different chromosomes. According to their distinct tissue distribution and subcellular localization, annexins have been functionally implicated in a variety of biological processes relevant to both physiological and pathological conditions. Dysregulation of annexin expression patterns and functions has been revealed as a common feature in multiple cancers, thereby emerging as potential biomarkers and molecular targets for clinical application. Nevertheless, translation of this knowledge to the clinic requires in-depth functional and mechanistic characterization of dysregulated annexins for each individual cancer type, since each protein exhibits varying expression levels and phenotypic specificity depending on the tumor types. This review specifically and thoroughly examines the current knowledge on annexin dysfunctions in carcinogenesis. Hence, available data on expression levels, mechanism of action and pathophysiological effects of Annexin A1-13 among different cancers will be dissected, also further discussing future perspectives for potential applications as biomarkers for early diagnosis, prognosis and molecular-targeted therapies. Special attention is devoted to head and neck cancers (HNC), a complex and heterogeneous group of aggressive malignancies, often lately diagnosed, with high mortality, and scarce therapeutic options.

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“…The protective anti-inflammatory action of ANXA1 has since been demonstrated in several models, including arthritis, heterologous skin transplantation, cancer, eye allergy, heart failure, lung injury, nonalcoholic steatosis, myocardial infarction, and skeletal muscle injury [19][20][21][22][23][24][25][26][27][28][29][30].…”

Section: Anxa1 and Inflammatory Processesmentioning

confidence: 99%

ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus

Sousa

Santos

Teixeira

et al. 2022

Cells

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The unbiased approaches of the last decade have enabled the collection of new data on the biology of annexin A1 (ANXA1) in a variety of scientific aspects, creating opportunities for new biomarkers and/or therapeutic purposes. ANXA1 is found in the plasma membrane, cytoplasm, and nucleus, being described at low levels in the nuclear and cytoplasmic compartments of placental cells related to gestational diabetic diseases, and its translocation from the cytoplasm to the nucleus has been associated with a response to DNA damage. The approaches presented here open pathways for reflection upon, and intrinsic clarification of, the modulating action of this protein in the response to genetic material damage, as well as its level of expression and cellular localization. The objective of this study is to arouse interest, with an emphasis on the mechanisms of nuclear translocation of ANXA1, which remain underexplored and may be beneficial in new inflammatory therapies.

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Annexin A1 peptide and endothelial cell‐conditioned medium modulate cervical tumorigenesis

Cited by 9 publications

References 60 publications

Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer

Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer

Pathobiological functions and clinical implications of annexin dysregulation in human cancers

ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus

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