Annexin-1-mediated Endothelial Cell Migration and Angiogenesis Are Regulated by Vascular Endothelial Growth Factor (VEGF)-induced Inhibition of miR-196a Expression

Pin, Anne Laure; Houle, François; Fournier, Patrick; Guillonneau, Maëva; Paquet, Éric R.; Simard, Martin J.; Royal, Isabelle; Huot, Jacques

doi:10.1074/jbc.m112.393561

Cited by 65 publications

(65 citation statements)

References 49 publications

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“…ANXA1 has been shown to regulate the migration of many kinds of cells, such as neutrophils [27] and endothelial cells [28]. ANXA1 was also found to play critical roles in the engulfment and phagocytosis of apoptotic cells [15,16].…”

Section: Discussionmentioning

confidence: 99%

Annexin-1 Mediates Microglial Activation and Migration via the CK2 Pathway during Oxygen–Glucose Deprivation/Reperfusion

Liu

Gao

et al. 2016

IJMS

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Annexin-1 (ANXA1) has shown neuroprotective effects and microglia play significant roles during central nervous system injury, yet the underlying mechanisms remain unclear. This study sought to determine whether ANXA1 regulates microglial response to oxygen–glucose deprivation/reperfusion (OGD/R) treatment and to clarify the downstream molecular mechanism. In rat hippocampal slices, OGD/R treatment enhanced the ANXA1 expression in neuron, the formyl peptide receptor (FPRs) expression in microglia, and the microglial activation in the CA1 region (cornu ammonis 1). These effects were reversed by the FPRs antagonist Boc1. The cell membrane currents amplitude of BV-2 microglia (the microglial like cell-line) was increased when treated with Ac2-26, the N-terminal peptide of ANXA1. Ac2-26 treatment enhanced BV-2 microglial migration whereas Boc1 treatment inhibited the migration. In BV-2 microglia, both the expression of the CK2 target phosphorylated α-E-catenin and the binding of casein kinase II (CK2) with α-E-catenin were elevated by Ac2-26, these effects were counteracted by the CK2 inhibitor TBB and small interfering (si) RNA directed against transcripts of CK2 and FPRs. Moreover, both TBB and siRNA-mediated inhibition of CK2 blocked Ac2-26-mediated BV-2 microglia migration. Our findings indicate that ANXA1 promotes microglial activation and migration during OGD/R via FPRs, and CK2 target α-E-catenin phosphorylation is involved in this process.

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Section: Discussionmentioning

confidence: 99%

Annexin-1 Mediates Microglial Activation and Migration via the CK2 Pathway during Oxygen–Glucose Deprivation/Reperfusion

Liu

Gao

et al. 2016

IJMS

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“…17 Activation of annexin A1 is involved in vascular endothelial growth factor-induced endothelial migration. 23 Overexpression of calreticulin blocks trophoblast migration. 24 It is now accepted that progesterone provides a better environment for endometrial remodeling by inducing endothelial migration and new vessel formation in decidual tissues.…”

Section: Progestrone Anti-inflammatory Proteins and Cytoskeletonmentioning

confidence: 99%

Proteomic Analyses Reveal the Role of Progesterone and Inducible Nitric Oxide Synthase in Uterine Remodeling during Pregnancy

Wang¹,

Chen

et al. 2012

Journal of Experimental & Clinical Medicine

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“…Vascular endothelial growth factor (VEGF) is another important factor regulating angiogenesis, and angiogenesis is important in tumour growth and metastasis. Pin et al [22] found that VEGF-induced cell migration and angiogenesis of miR-196a can change the expression level of ANXA1, which is controlled by p38-ANXA1 signal conduction pathway. The function of Helicobacter pylori (H. pylori) infection in GC has also been demonstrated, showing that H. pylori can change the cellular ANXA1 localization [23] .…”

Section: Discussionmentioning

confidence: 99%

Identification of Annexin A1 protein expression in human gastric adenocarcinoma using proteomics and tissue microarray

Zhang

Li²,

Liu³

et al. 2013

WJG

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AIM:To study the differential expression of Annexin A1 (ANXA1) protein in human gastric adenocarcinoma. This study was also designed to analyze the relationship between ANXA1 expression and the clinicopathological parameters of gastric carcinoma. O after trypsin digestion. Differential protein expressions were quantitatively identified between GAC and NGEC by nanoliter-reverse-phase liquid chromatography-mass/mass spectrometry (nano-RPLC-MS/MS). The expressions of ANXA1 in GAC and NGEC were verified by western blot analysis. The tissue microarray containing the expressed ANXA1 in 75 pairs of gastric carcinoma and paracarcinoma specimens was detected by immunohistochemistry (IHC). The relationship between ANXA1 expression and clinicopathological parametes of gastric carcinoma was analyzed. METHODS: RESULTS:A total of 78 differential proteins were identified. Western blotting revealed that ANXA1 expression was significantly upregulated in GAC (2.17/1, P < 0.01).IHC results showed the correlations between ANXA1 protein expression and the clinicopathological parameters, including invasive depth (T stage), lymph node metastasis (N stage), distant metastasis (M stage) and tumour-lymph node metastasis stage (P < 0.01). However, the correlations between ANXA1 protein expression and the remaining clinicopathological parameters, including sex, age, histological differentiation and the size of tumour were not found (P > 0.05). CONCLUSION:The upregulated ANXA1 expression may be associated with carcinogenesis, progression, invasion and metastasis of GAC. This protein could be considered as a biomarker of clinical prognostic prediction and targeted therapy of GAC.

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Annexin-1-mediated Endothelial Cell Migration and Angiogenesis Are Regulated by Vascular Endothelial Growth Factor (VEGF)-induced Inhibition of miR-196a Expression

Cited by 65 publications

References 49 publications

Annexin-1 Mediates Microglial Activation and Migration via the CK2 Pathway during Oxygen–Glucose Deprivation/Reperfusion

Annexin-1 Mediates Microglial Activation and Migration via the CK2 Pathway during Oxygen–Glucose Deprivation/Reperfusion

Proteomic Analyses Reveal the Role of Progesterone and Inducible Nitric Oxide Synthase in Uterine Remodeling during Pregnancy

Identification of Annexin A1 protein expression in human gastric adenocarcinoma using proteomics and tissue microarray

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