Anluohuaxianwan alleviates carbon tetrachloride-induced hepatic fibrosis in rats through upregulation of peroxisome proliferator-activated receptor-gamma and downregulation of nuclear factor-kappa B/IκBα signaling pathway

Wang, Lin; Lü, Wei; Gao, Yuhua; Yan, Haijiang; Pei, Fei; Liu, Xue-En; Zhang, Hui

doi:10.4103/wjtcm.wjtcm_16_19

Cited by 5 publications

(2 citation statements)

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“…The liver was harmed by multiple pathogenic agents, which led to hepatic fibrosis. It is well-documented that an inflammatory micro-environment, oxidative stress, and excessive deposition of ECM must be orchestrated to inhibit the progress of liver fibrosis ( Liu et al, 2022 ; Rodríguez et al, 2021 ). Many other studies confirmed CCl 4 induced a liver fibrosis model (liver cirrhosis), which has applied extensively by a multitude of researchers ( Scholten et al, 2015 ; Cong et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Available and novel plant-based carbon dots derived from Vaccaria Semen carbonisata alleviates liver fibrosis

Zhao,

Dai,

Dong

et al. 2023

Front. Mol. Biosci.

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Background: Liver fibrosis represents an intermediate stage in the progression of liver disease, and as of now, there exists no established clinical therapy for effective antifibrotic treatment.Purpose: Our aim is to explore the impact of Carbon dots derived from Vaccaria Semen Carbonisata (VSC-CDs) on carbon tetrachloride-induced liver fibrosis in mice.Methods: VSC-CDs were synthesized employing a modified pyrolysis process. Comprehensive characterization was performed utilizing various techniques, including transmission electron microscopy (TEM), multiple spectroscopies, X-ray photoelectron spectroscopy (XPS), and high-performance liquid chromatography (HPLC). A hepatic fibrosis model induced by carbon tetrachloride was utilized to evaluate the anti-hepatic fibrosis effects of VSC-CDs.Results: VSC-CDs, exhibiting a quantum yield (QY) of approximately 2.08%, were nearly spherical with diameters ranging from 1.0 to 5.5 nm. The VSC-CDs prepared in this study featured a negative charge and abundant chemical functional groups. Furthermore, these particles demonstrated outstanding dispersibility in the aqueous phase and high biocompatibility. Moreover, VSC-CDs not only enhanced liver function and alleviated liver damage in pathomorphology but also mitigated the extent of liver fibrosis. Additionally, this study marks the inaugural demonstration of the pronounced activity of VSC-CDs in inhibiting inflammatory reactions, reducing oxidative damage, and modulating the TGF-β/Smad signaling pathway.Conclusion: VSC-CDs exerted significant potential for application in nanodrugs aimed at treating liver fibrosis.

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Section: Discussionmentioning

confidence: 99%

Available and novel plant-based carbon dots derived from Vaccaria Semen carbonisata alleviates liver fibrosis

Zhao,

Dai,

Dong

et al. 2023

Front. Mol. Biosci.

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“…NF-κB is a crucial transcription factor that acts downstream of the TLR4 signaling pathway [36], which regulates immunological responses and is thought to be the beginning factor of several infammatory reactions. Its activation can cause infammation as well as the aggregation of the microtubuleassociated protein light chain 3 (LC3) and the ubiquitination of Beclin-1, which can then activate autophagy [37]. Te TLR4/NF-κB pathway is a signal transduction system that has been linked to infammatory immunological mechanisms and the regulation of infammation as well as the regulation of autophagy [38].…”

Section: Discussionmentioning

confidence: 99%

Bushen Wenyang Huayu Decoction Targets TLR4/NF-κB Mediated Autophagy to Treat Endometriosis Effectively

Liu

Meng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Endometriosis has been found to be closely related to autophagy. This study aimed to elucidate the possible mechanism of Bushen Wenyang Huayu Decoction (BWHD) in treating endometriosis (EMs) by targeting TLR4/NF-κB-mediated autophagy. Autologous grafting was used to generate the EMs model in rats. Once the model was developed, BWHD high-dose and low-dose groups received intragastric administration of BWHD, and the gestrinone group served as a positive control. Immunofluorescence labeling and Western blotting were used for the protein expression of toll-like receptor 4 (TLR4), nuclear transcription factor-κB (NF-κB), Beclin-1, and selective autophagy connector protein P62 (P62). Quantitative real-time polymerase chain reaction (qRT-PCR) was used to analyze mRNA levels of TLR4, NF-κB, Beclin-1, and P62. We found that BWHD significantly reduced the size of ectopic lesions in rats with EMs, regulated reproductive hormone levels, and alleviated the cell autophagy level. It suggested that BWHD could be an effective treatment of EMs by targeting TLR4/NF-κB signaling pathway.

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Si Miao Formula attenuates non-alcoholic fatty liver disease by modulating hepatic lipid metabolism and gut microbiota

et al. 2021

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Anluohuaxianwan alleviates carbon tetrachloride-induced hepatic fibrosis in rats through upregulation of peroxisome proliferator-activated receptor-gamma and downregulation of nuclear factor-kappa B/IκBα signaling pathway

Cited by 5 publications

References 0 publications

Available and novel plant-based carbon dots derived from Vaccaria Semen carbonisata alleviates liver fibrosis

Available and novel plant-based carbon dots derived from Vaccaria Semen carbonisata alleviates liver fibrosis

Bushen Wenyang Huayu Decoction Targets TLR4/NF-κB Mediated Autophagy to Treat Endometriosis Effectively

Si Miao Formula attenuates non-alcoholic fatty liver disease by modulating hepatic lipid metabolism and gut microbiota

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