Ankyrins

Рубцов, А.М.; Лопина, О.Д.

doi:10.1016/s0014-5793(00)01924-4

Cited by 111 publications

(79 citation statements)

References 56 publications

(59 reference statements)

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“…The mRNAs of the glycoproteins dystroglycan 1 and ␤-sarcoglycan were upregulated. Ankyrins are protein linkers between the integral membrane proteins and spectrin-based cytoskeleton (Rubtsov and Lopina 2000). Through their interaction with cytoskeleton proteins such as vimentin or tubulin, they participate in the attachment of the intermediary filaments and microtubules to the membrane.…”

Section: Modulation Of Cytoskeletal Protein Expressionmentioning

confidence: 99%

In Vivo Regulation of Human Skeletal Muscle Gene Expression by Thyroid Hormone

Clément¹,

Viguerie²,

Diehn³

et al. 2002

Genome Res.

150

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Thyroid hormones are key regulators of metabolism that modulate transcription via nuclear receptors. Hyperthyroidism is associated with increased metabolic rate, protein breakdown, and weight loss. Although the molecular actions of thyroid hormones have been studied thoroughly, their pleiotropic effects are mediated by complex changes in expression of an unknown number of target genes. Here, we measured patterns of skeletal muscle gene expression in five healthy men treated for 14 days with 75 µg of triiodothyronine, using 24,000 cDNA element microarrays. To analyze the data, we used a new statistical method that identifies significant changes in expression and estimates the false discovery rate. The 381 up-regulated genes were involved in a wide range of cellular functions including transcriptional control, mRNA maturation, protein turnover, signal transduction, cellular trafficking, and energy metabolism. Only two genes were down-regulated. Most of the genes are novel targets of thyroid hormone. Cluster analysis of triiodothyronine-regulated gene expression among 19 different human tissues or cell lines revealed sets of coregulated genes that serve similar biologic functions. These results define molecular signatures that help to understand the physiology and pathophysiology of thyroid hormone action.

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Section: Modulation Of Cytoskeletal Protein Expressionmentioning

confidence: 99%

In Vivo Regulation of Human Skeletal Muscle Gene Expression by Thyroid Hormone

Clément¹,

Viguerie²,

Diehn³

et al. 2002

Genome Res.

150

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“…They are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton, which in muscle forms a highly complex network of inter-myofibril connections as well as connections between myofibrils and the sarcolemma [1,2] and the sarcoplasmic reticulum [2-5]. Ankyrin contains a regulatory domain which is sensitive to proteolysis [6]. Ankyrins are a known target of the calpains [7-9] which are a family of endogenous cysteine proteases that have been shown to be fundamental to the post-mortem proteolysis of myofibrillar proteins and cytoskeletal proteins and consequent meat tenderisation [10-14].…”

Section: Introductionmentioning

confidence: 99%

Regulatory polymorphisms in the bovine Ankyrin 1 gene promoter are associated with tenderness and intramuscular fat content

et al. 2010

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BackgroundRecent QTL and gene expression studies have highlighted ankyrins as positional and functional candidate genes for meat quality. Our objective was to characterise the promoter region of the bovine ankyrin 1 gene and to test polymorphisms for association with sensory and technological meat quality measures.ResultsSeven novel promoter SNPs were identified in a 1.11 kb region of the ankyrin 1 promoter in Angus, Charolais and Limousin bulls (n = 15 per breed) as well as 141 crossbred beef animals for which meat quality data was available. Eighteen haplotypes were inferred with significant breed variation in haplotype frequencies. The five most frequent SNPs and the four most frequent haplotypes were subsequently tested for association with sensory and technological measures of meat quality in the crossbred population. SNP1, SNP3 and SNP4 (which were subsequently designated regulatory SNPs) and SNP5 were associated with traits that contribute to sensorial and technological measurements of tenderness and texture; Haplotype 1 and haplotype 4 were oppositely correlated with traits contributing to tenderness (P < 0.05). While no single SNP was associated with intramuscular fat (IMF), a clear association with increased IMF and juiciness was observed for haplotype 2.ConclusionThe conclusion from this study is that alleles defining haplotypes 2 and 4 could usefully contribute to marker SNP panels used to select individuals with improved IMF/juiciness or tenderness in a genome-assisted selection framework.

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“…1), was found for ANK-2 and ANK-3 in D1701-infected cells (data not shown). Numerous prokaryotic and eukaryotic proteins acting as protein linkers use the ankyrin repeats as binding domains for protein-protein interactions, thereby influencing cell-cycle control, cell differentiation and host immunity (Ghosh et al, 1998;Rubtsov & Lopina, 2000). The cowpoxvirus-encoded ankyrin repeat protein gene CHOhr determines cell tropism (Spehner et al, 1988) and functions as an anti-apoptotic gene (Ink et al, 1995).…”

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confidence: 99%