2001
DOI: 10.1083/jcb.200109026
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Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments

Abstract: The axon initial segment is an excitable membrane highly enriched in voltage-gated sodium channels that integrates neuronal inputs and initiates action potentials. This study identifies Nav1.6 as the voltage-gated sodium channel isoform at mature Purkinje neuron initial segments and reports an essential role for ankyrin-G in coordinating the physiological assembly of Nav1.6, βIV spectrin, and the L1 cell adhesion molecules (L1 CAMs) neurofascin and NrCAM at initial segments of cerebellar Purkinje neurons. Anky… Show more

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Cited by 407 publications
(458 citation statements)
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“…1A3). These results indicate that Na V 1.1 and Na V 1.6 are the predominant sodium channels in the cell bodies and dendrites of Purkinje neurons, in agreement with previous work (Westenbroek et al, 1989;Gong et al, 1999;Caldwell et al, 2000;Jenkins and Bennett, 2001;Schaller and Caldwell, 2003). The observed distribution of Na V channels in P13-P14 cerebellar neurons in our experiments indicates that Na V 1.1 and Na V 1.6 channels conduct nearly all sodium current in Purkinje neurons in this age range.…”
Section: Resultssupporting
confidence: 93%
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“…1A3). These results indicate that Na V 1.1 and Na V 1.6 are the predominant sodium channels in the cell bodies and dendrites of Purkinje neurons, in agreement with previous work (Westenbroek et al, 1989;Gong et al, 1999;Caldwell et al, 2000;Jenkins and Bennett, 2001;Schaller and Caldwell, 2003). The observed distribution of Na V channels in P13-P14 cerebellar neurons in our experiments indicates that Na V 1.1 and Na V 1.6 channels conduct nearly all sodium current in Purkinje neurons in this age range.…”
Section: Resultssupporting
confidence: 93%
“…However, Na V 1.1 channels are localized primarily in the cell bodies of Purkinje neurons (Westenbroek et al, 1989;Gong et al, 1999) (Fig. 1) (but see also Ogiwara et al, 2007), whereas Na V 1.6 channels are localized in cell bodies, dendrites, and axon initial segments Jenkins and Bennett, 2001;Schaller and Caldwell, 2003) (Fig. 1).…”
Section: Discussionmentioning
confidence: 98%
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“…During postnatal development of the AIS, ankyrinG often appears in advance of Na V 1s (Jenkins and Bennett, 2001). In mutant ankyrin-deficient neurons, there is an abnormal distribution of CAMs, ␤-spectrin, and Na V 1s and an inability to generate action potentials (Zhou et al, 1998;Jenkins and Bennett, 2001).…”
Section: Discussionmentioning
confidence: 99%
“…A clear decrease in the labeling of ␣-fodrin (Fig. 8C), a form of spectrin to which ankyrinG is likely to bind (Jenkins and Bennett, 2001), was observed in the region of high AChR density. In contrast, utrophin, a protein closely associated with the region of high AChR density in mammals Matsumura et al, 1992), occupied precisely the same domain as the AChRs (Fig.…”
Section: Syntrophin Is Concentrated At Sites Of High Achr Density Fromentioning
confidence: 98%