Ankylosing spondylitis and the risk of fracture: results from a large primary care-based nested case-control study

Vosse, Debby; Landewé, Robert; Heijde, Desirée van der; Linden, S van der; Staa, Tjeerd van; Geusens, Piet

doi:10.1136/ard.2008.100503

Cited by 168 publications

(122 citation statements)

References 26 publications

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“…[5,3] In general, AS is associated with bone loss in the vertebrae and an increased prevalence of vertebral fractures. [6,7] Cooper et al [6] identified markedly increased relative risk of vertebral morphometric deformities in patients with AS compared with the control population. The review of recent literature on osteoporosis and vertebral fractures in AS published by DaveyÀRanasinghe and Deodhar [8] suggests that the prevalence of osteoporosis in AS patients is 25% and that of vertebral fractures is 10%.…”

Section: Introductionmentioning

confidence: 99%

Relationship between physical function, disease activity, spinal mobility and bone parameters (trabecular bone score and bone mineral density) in ankylosing spondylitis patients

Ivanova

Manolova

Boyadzhieva

et al. 2015

Biotechnology & Biotechnological Equipment

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(2015) Relationship between physical function, disease activity, spinal mobility and bone parameters (trabecular bone score and bone mineral density) in ankylosing spondylitis patients, Biotechnology & Biotechnological Equipment, 29:5, 956-962, DOI: 10.1080/13102818.2015 This study aimed to evaluate the relationship between physical function, disease activity, spinal mobility and bone parameters in ankylosing spondylitis (AS) patients. Fifty patients (27 men and 23 women) were examined. The clinical assessment included Bath AS Disease Activity Index, AS Disease Activity Score, Bath AS Functional Index, Bath AS Metrology Index (BASMI). Lumbar spine and femoral neck bone mineral density (BMD), spinal trabecular bone score (TBS) and the TBS T-score were calculated by dual-energy X-ray absorptiometry. Prevalence rates for osteoporosis and osteopaenia were 14% and 36%, respectively and for partially and fully degraded microarchitecture À 34% and 16%, respectively. A similar inverse correlation was observed between BASMI and TBS, TBS T-score and femoral BMD bone parameters, which were significantly lower in patients 45 years of age. No significant correlations were detected between any bone parameter and indicators of disease activity and physical function. Patients with a disease duration of 10 years tended to exhibit either normal or elevated spine BMD. Femoral BMD was lower in men. The higher BASMI was associated with an increased likelihood of TBS < 1.350 (odds ratio (OR) D 1.44, 1.05À1.97, p D 0.024) and TBS T-score < À1.00 (OR D 1.55, 1.11À2.16, p D 0.01). In summary, lumbar spine BMD can be erroneously influenced by osteoproliferation, unlike the TBS and TBS T-score. The limitations in spinal mobility predicted abnormal results for these two TBS parameters. TBS may be a better indicator of bone health than BMD in AS.

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Section: Introductionmentioning

confidence: 99%

Relationship between physical function, disease activity, spinal mobility and bone parameters (trabecular bone score and bone mineral density) in ankylosing spondylitis patients

Ivanova

Manolova

Boyadzhieva

et al. 2015

Biotechnology & Biotechnological Equipment

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“…1 It has been hypothesized that, in common with other chronic inflammatory arthritides such as rheumatoid arthritis and spondyloarthropathy, 2,3 gout may be associated with an increased risk of fracture, primarily owing to the negative effects of chronic inflammation on bone, because proinflammatory cytokines are known to induce bone loss. However, the effects of serum urate on bone health are still under debate 4,5 and previous studies that have assessed the impact of gout and urate-lowering therapy on fracture risk have provided conflicting results.…”

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confidence: 99%

Risk of fragility fracture among patients with gout and the effect of urate-lowering therapy

Sultan

Whittle

Müller

et al. 2018

CMAJ

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“…The increased risk is more strongly related to daily dose than to the cumulative dose with a monotonic relationship [48]. Several early studies documented an increased fracture risk in subjects with rheumatoid [61][62][63] and psoriatic arthritis [64], ankylosing spondyloarthritis [65][66] and in general with any connective tissue disease. Relative risks associated with each CRF described above and used in the model are reported in Table VII.…”

Section: Clinical Risk Factorsmentioning

confidence: 99%

Simulating the development and progression of Chronic Kidney Disease and osteoporosis in people living with HIV

Адами¹,

Maggi²,

Montinaro³

et al. 2016

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The "chronicization" of HIV infection brings about a growing necessity to attentively evaluate current and potential complications when prescribing the individual therapeutic regimen. Starting from this need, we developed two HIV-comorbidity simulators that, basing on the evidence available in medical literature and starting from the current clinical and demographic features of the individual patient, project and compare the risks of developing and worsening of nephropathy and osteopathy associated with possible ARV regimens. These simulators are embedded in a desktop, user-friendly software thought to be used by the treating physician during prescription discussion with his/her patients, in order to highlight expected clinical outcomes and healthcare resource consumption that may differ according to the therapeutic strategy selected. In this article we present the sources and methods used in developing the mathematical models, alongside a set of examples and the results of cohort-level validation runs.

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Ankylosing spondylitis and the risk of fracture: results from a large primary care-based nested case-control study

Cited by 168 publications

References 26 publications

Relationship between physical function, disease activity, spinal mobility and bone parameters (trabecular bone score and bone mineral density) in ankylosing spondylitis patients

Relationship between physical function, disease activity, spinal mobility and bone parameters (trabecular bone score and bone mineral density) in ankylosing spondylitis patients

Risk of fragility fracture among patients with gout and the effect of urate-lowering therapy

Simulating the development and progression of Chronic Kidney Disease and osteoporosis in people living with HIV

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