Ankylosing Spondylitis and Its Association With the Histocompatibility Antigen Hl-a B27: An Epidemiological and Clinical Study

Al-Rawi, Ziad S.; Al-Shakarchi, H. A.; Hasan, Fatima A.; Thewaini, A. J.

doi:10.1093/rheumatology/17.2.72

Cited by 19 publications

(13 citation statements)

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“…The overall percentage was 69% and a higher prevalence was found among locals (82%). This prevalence in Qataris is close to the prevalence in the West and to the prevalence reported in Jordan of 75 and 81% and in Iraq of 84% [5, 14, 15]. …”

Section: Discussionsupporting

confidence: 74%

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Prevalence of HLA-B27 in Patients with Ankylosing Spondylitis in Qatar

Abdelrahman

Mahdy

Khanjar

et al. 2012

International Journal of Rheumatology

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Background and Objectives. The human leukocyte antigen HLA-B27 is a class 1 antigen of the major histocompatibility complex and is strongly associated with ankylosing spondylitis (AS). The purpose of the present study is to investigate the distribution of HLA-B27 in patients with AS of different ethnic groups in Qatar. Design and Setting. Study design was cross-sectional and the setting was rheumatology clinics of Hamad General Hospital in Qatar where most of ankylosing spondylitis patients are followed up. Patients and Methods. Patients with diagnosis of AS who met the New York modified criteria for AS were tested for HLA-B27. 119 patients were tested for HLA-B27: 66 Arabs, 52 Asians (Indians, Pakistanis, Bengalis, and Iranians), and one Western (Irish). Results. Of all the individuals, 82 were positive (69%) for HLA-B27. Among the Arabs, 49/66 were positive (74%). Among the Asians, 32/52 were positive (61%). Furthermore, Qatari patients (10 males and one female) 9 were positive (82%), 14/19 Jordanians/Palestinians were positive, and 9/10 (90%) Egyptians were positive. Among the Asians, 19/26 Indians were positive (73%), which was similar to the Arabs. Conclusion. HLA-B27 in our small group of Arabs is present in 74%. Comparison with other data will be presented in detail.

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Section: Discussionsupporting

confidence: 74%

“…The prevalence of HLA-B27 among AS patients in the Arab world is generally lower than the worldwide figure, ranging from 56 to 84%: 84% in Iraq, 56% in UAE, 67% in Saudi Arabia, 58.6% in Egypt, 60% in Syria, and 73.4% in Iran [5, 9–12]. …”

Section: Introductionmentioning

confidence: 99%

Prevalence of HLA-B27 in Patients with Ankylosing Spondylitis in Qatar

Abdelrahman

Mahdy

Khanjar

et al. 2012

International Journal of Rheumatology

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“…For the Middle East, limited available data showed that AS is relatively uncommon in this part of the world. In Iraq a prevalence was reported of 0.07% [70] and in Iran of 0.14 [71]. For Australia, there is no evidence to support the occurrence of AS in the indigenous Australian Aborigines with pure ancestry, probably related to the very low frequency of HLA-B27 in this population [72].…”

Section: Literature Review On Prevalence and Incidence Spamentioning

confidence: 99%

Epidemiology of Spondyloarthritis

Stolwijk

Boonen

Tubergen

et al. 2012

Rheumatic Disease Clinics of North America

197

125

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Synopsis Spondyloarthritis (SpA) represents a group of interrelated diseases with common clinical features and a close association with HLA-B27. Figures on the incidence and prevalence of diseases vary highly dependent on methodological differences between studies, the case definition used to classify disease and on the prevalence of HLA-B27 in the population studied. When summarizing the available literature, incidence rates of SpA are mainly based on the ESSG criteria and range between 0.48 and 63/100.000 while prevalence rates vary between 0.01 and 2.5%. For ankylosing spondylitis (AS), the most widely recognized representative of the SpA group of diseases, incidence rates of 0.44-7.3/100.000 and prevalence rates of 0.007-1.7% have been described in studies that were based on the (modified) New York criteria to classify cases. The incidence of psoriatic arthritis (PsA) varied from 3.6 up to 23.1/100.000 in different studies and prevalence between <0.1% and 0.4%, using a variety of classification criteria. The incidence of ReA has been estimated between 0.6 up to 28/100.000 in studies based on different source populations and different case definitions. The newly proposed criteria for axial SpA and peripheral SpA present an attractive new approach to facilitate classification of the SpA into two main subtypes and the axial SpA criteria allow earlier detection of patents with inflammatory back pain. It should be emphasized that these criteria were developed for use in a (specialized) clinical setting and not for large epidemiological studies.

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“…HLA-B27 is strongly associated with AS in (97%) of the patients. In Iraq, there is a strong association between Ankylosing spondylitis and (HLA-B27) [19].…”

Section: Diseases Linked To Hla Specificitiesmentioning

confidence: 99%

Relationship between HLA Typing and Different Diseases in IRAQ

Mahdi¹

2013

Clon Transgen

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Human leukocyte antigen system is the major histocompatibility complex in humans, which includes several hundreds of genes located in a highly polymorphic region of chromosome 6 that encode for proteins critical for the immune system. HLA Class I antigens (A, B and C) transport and present peptides produced by degradation of proteins inside the cell like viral antigens, to CD8+ T cells, in addition to that the HLA Class I, carry also foreign or not-self antigens. Under normal conditions, these T -cell CD 8+ cells recognize but do not destroy those cells with the right "self"Ag, unless they also carry a non-self antigen. Under pathological conditions, like in certain autoimmune diseases T cells can destroy cells carrying self-antigens, causing autoimmune diseases. The role of HLA Class II antigens (DRB1, DRB3,4,5, DQA1/DQB1, DPB1) is to present the peptides from processed proteins that are produced outside the cell, derived from bacteria and protozoa, to helper T-cells CD4+ to stimulate their multiplication. These helper T cells then stimulate B-cells to produce antibodies against the foreign antigens. HLA and disease associations have been widely studied across the populations worldwide and are found to be important in prediction of disease susceptibility, resistance or protective and of evolutionary maintenance of genetic diversity. Here, in this review, we have collected HLA association data on some autoimmune diseases, infectious diseases, cancers, and other diseases with unknown etiology in Iraq and attempt to summarize some remarkable HLA alleles related with specific diseases.

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Ankylosing Spondylitis and Its Association With the Histocompatibility Antigen Hl-a B27: An Epidemiological and Clinical Study

Cited by 19 publications

References 0 publications

Prevalence of HLA-B27 in Patients with Ankylosing Spondylitis in Qatar

Prevalence of HLA-B27 in Patients with Ankylosing Spondylitis in Qatar

Epidemiology of Spondyloarthritis

Relationship between HLA Typing and Different Diseases in IRAQ

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