“…In Drosophila, Mask acts in the signal transduction pathway mediated by Cws (Corkscrew; orthologous of SHP2) (Smith, et al, 2002), participates in the Hippo signaling pathway activation through its association with Yki (Yorkie, orthologous of YAP1) (Sidor, et al, 2013, SansoresGarcia, et al, 2013 and potentially regulates Hop signaling pathway (Hopscotch, orthologous of JAK) (Muller, et al, 2005). In humans, ANKHD1 associates with SHP2, however the biologic consequence of this protein interaction remains indeterminate (Traina, et al, 2006). ANKHD1 and YAP1 interaction has also been confirmed in human cells (HEK293 and DU145 cells) and modulates the Hippo signaling pathway activation, proliferation and cell cycle progression (Sidor, et al, 2013, Sansores-Garcia, et al, 2013, Machado-Neto, et al, 2014.…”