The intermetallic compound CeRu 4 Sn 6 has been tentatively classified as Kondo insulator. This class of material, especially non-cubic representatives,is not yet fully understood. Here we report thermopower measurements on single-crystalline CeRu 4 Sn 6 between 2 K and 650 K, along the main crystallographic directions. Large positive thermopower is observed in the directions along which the hybridization is strong and a Kondo insulating gap forms. A negative contribution to the thermopower dominates for the crystallographic c axis where hybridization is weak and metallicity prevails.