Indirect searches for products of dark matter annihilation and decay face the challenge of identifying an uncertain and subdominant signal in the presence of uncertain backgrounds. Two valuable approaches to this problem are (i) using analysis methods which take advantage of different features in the energy spectrum and angular distribution of the signal and backgrounds and (ii) more accurately characterizing backgrounds, which allows for more robust identification of possible signals. These two approaches are complementary and can be significantly strengthened when used together. I review the status of indirect searches with gamma rays using two promising targets, the Inner Galaxy and the isotropic gamma-ray background. For both targets, uncertainties in the properties of backgrounds are a major limitation to the sensitivity of indirect searches. I then highlight approaches which can enhance the sensitivity of indirect searches using these targets.indirect detection | multiwavelength studies I ndirect dark matter detection offers a promising approach to detecting dark matter in an astrophysical context and may provide a means of mapping its spatial distribution and constraining its particle nature. Current searches for signatures of dark matter annihilation or decay using gamma rays have made substantial progress in recent years (1-7), with sensitivity to dark matter annihilation beginning to reach the favored regions of parameter space for thermal relic weakly interacting massive particle (WIMP) dark matter (8, 9).The most robust constraints on indirect dark matter signals are obtained by placing limits on the total amplitude of a dark matter signal without attempting any background modeling. For a few targets, such as Milky Way dwarf spheroidal galaxies (1, 2), the expected backgrounds are small, and thus, the sensitivity is not significantly weakened by neglecting to model the backgrounds. However, for many favorable indirect search targets in gamma rays, including the Inner Galaxy and the isotropic gamma-ray background (IGRB), the guaranteed backgrounds are substantial and currently not strongly constrained. As a result, dark matter searches in these regions could be made considerably more sensitive by improved knowledge of backgrounds.Although most indirect searches to date have resulted in limits being placed, in some cases, intriguing hints of a possible signal have been uncovered. Several groups have reported an excess in GeV gamma-ray emission originating from the Galactic Center (3,5,7,(10)(11)(12) and Inner Galaxy (12, 13); here I use Galactic Center to refer to the region within a few degrees of the dynamical center of the Galaxy and Inner Galaxy to refer to the region extending a few tens of degrees from the Galactic Center. However, in all of these studies the putative dark matter signal was detected using an approach that required some form of background modeling. Due to uncertainties in the emission from non-dark matter sources in this region, the interpretation of these possible detections of e...