Anisotropic material behaviours of soft tissues in human trachea: An experimental study

Zhang, Teng; Trabelsi, Olfa; Ochoa, Ignacio; He, Jing; Gillard, Jonathan H.; Doblaré, M.

doi:10.1016/j.jbiomech.2012.04.002

Cited by 42 publications

(44 citation statements)

References 41 publications

(56 reference statements)

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“…Importantly, it remains to be determined which attributes of these material properties are essential for the normal, healthy function of different tissues, as well as for successful tissue-engineered replacements. Nonetheless, great strides have been made in the past decade in our understanding of the more complex constitutive behaviors of tissue that involve anisotropic (Groves et al, 2013; Isenberg et al, 2012; Nagel and Kelly, 2012; Sommer et al, 2013; Teng et al, 2012), multiphasic (Azeloglu et al, 2008), viscoelastic (Shirakawa et al, 2013), nonlinear (Buckley et al, 2013), and transport (Motaghinasab et al, 2012) properties.…”

Section: Principles Of Functional Tissue Engineeringmentioning

confidence: 99%

Biomechanics and mechanobiology in functional tissue engineering

Guilak

Butler

Goldstein

et al. 2014

Journal of Biomechanics

195

123

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The field of tissue engineering continues to expand and mature, and several products are now in clinical use, with numerous other preclinical and clinical studies underway. However, specific challenges still remain in the repair or regeneration of tissues that serve a predominantly biomechanical function. Furthermore, it is now clear that mechanobiological interactions between cells and scaffolds can critically influence cell behavior, even in tissues and organs that do not serve an overt biomechanical role. Over the past decade, the field of “functional tissue engineering” has grown as a subfield of tissue engineering to address the challenges and questions on the role of biomechanics and mechanobiology in tissue engineering. Originally posed as a set of principles and guidelines for engineering of load-bearing tissues, functional tissue engineering has grown to encompass several related areas that have proven to have important implications for tissue repair and regeneration. These topics include measurement and modeling of the in vivo biomechanical environment; quantitative analysis of the mechanical properties of native tissues, scaffolds, and repair tissues; development of rationale criteria for the design and assessment of engineered tissues; investigation of the effects biomechanical factors on native and repair tissues, in vivo and in vitro; and development and application of computational models of tissue growth and remodeling. Here we further expand this paradigm and provide examples of the numerous advances in the field over the past decade. Consideration of these principles in the design process will hopefully improve the safety, efficacy, and overall success of engineered tissue replacements.

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Section: Principles Of Functional Tissue Engineeringmentioning

confidence: 99%

Biomechanics and mechanobiology in functional tissue engineering

Guilak

Butler

Goldstein

et al. 2014

Journal of Biomechanics

195

123

View full text Add to dashboard Cite

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“…The studies that we conducted into preferable storage and preparation protocols were based on published conditions used for studying the mechanical properties of trachea (e.g., [6,9,10]), namely, dry storage at −20…”

Section: Resultsmentioning

confidence: 99%

“…Samples have been studied under both compression and tension. For these specimens, the moduli ranges from the order of 10 kPA to the order of 100 MPa [6][7][8][9][10]. These variations in modulus values have been attributed to species-specific differences in the tissues and to sample orientation [6].…”

Section: Introductionmentioning

confidence: 99%

Comparative quasi-static mechanical characterization of fresh and stored porcine trachea specimens

Butler

Williams

Tucker

et al. 2018

Eur. Phys. J. Spec. Top.

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Abstract. Tissues of the upper airways of critically ill patients are particularly vulnerable to mechanical damage associated with the use of ventilators. Ventilation is known to disrupt the structural integrity of respiratory tissues and their function. This damage contributes to the vulnerability of these tissues to infection. We are currently developing tissue models of damage and infection to the upper airways. As part of our studies, we have compared how tissue storage conditions affect mechanical properties of excised respiratory tissues using a quasi-static platform. Data presented here show considerable differences in mechanical responses of stored specimens compared to freshly excised specimens. These data indicate that implementation of storage and maintenance procedures that minimize rapid degradation of tissue structure are essential for retaining the material properties in our tissue trauma models.

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“…Although the cartilaginous rings support the cylindrical shape and resist airway compression, the connective tissues enable the trachea to bend, expand, and bear tensile loads. [4][5][6][7]11,12 The epithelium comprises several different cell types such as ciliated cells, goblet cells, secretory cells, and resident basal cells that are integral to the epithelial repair and renewal process. [8][9][10]13,14 Characteristics of an ideal tracheal replacement have been said to include lateral rigidity, longitudinal flexibility, lining of respiratory epithelium, air-tight anastomoses, ability to integrate into adjacent tissue, no requirement for immunosuppressive therapy, and implantability using straightforward surgical techniques.…”

mentioning

confidence: 99%

“…[8][9][10]13,14 Characteristics of an ideal tracheal replacement have been said to include lateral rigidity, longitudinal flexibility, lining of respiratory epithelium, air-tight anastomoses, ability to integrate into adjacent tissue, no requirement for immunosuppressive therapy, and implantability using straightforward surgical techniques. 1,11,12,15 To date, no tracheal replacement has met all of these criteria.…”

mentioning

confidence: 99%