Anisotropic elastic behavior of a hydrogel-coated electrospun polyurethane: Suitability for heart valve leaflets

Motiwale, Shruti; Russell, Madeleine; Conroy, Olivia; Carruth, J. A. S.; Wancura, Megan; Robinson, Andrew; Cosgriff‐Hernandez, Elizabeth; Sacks, Michael S.

doi:10.1016/j.jmbbm.2021.104877

Cited by 17 publications

(23 citation statements)

References 57 publications

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“…In addition to the modification of polymer chemical structure and composition of components, the construction of physical structure is also of interest. A polycarbonate polyurethane (ES‐PCU) electrospun film with a poly(ethylene glycol) diacrylate (PEGDA) hydrogel coating was constructed [138] . The hydrogel coating improves the biocompatibility of ES‐PCU as the leaflet of heart valves.…”

Section: Development Of Novel Polymeric Valvesmentioning

confidence: 99%

Prosthetic heart valves for transcatheter aortic valve replacement

Peng

et al. 2023

BMEMat

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Transcatheter aortic valve replacement (TAVR) has the advantages of less trauma and faster postoperative recovery, which has brought the possibility to the elderly patient with valvular heart disease and is gradually replacing surgical aortic valve replacement (SAVR). The interventional valve used in TAVR needs to be compressed and transported through the catheter to the lesion site, and can still recover its original shape, structure and performance. This process requires that the material should be flexible, and the rigid mechanical valves in SAVR are not suitable. Recently, decellularized biological valves have been widely used in clinical practice, but their poor durability causes a limitation for long-term implantation. Therefore, the anti-calcification modification of biological valves and the design of new polymeric valves with good biostability have gained considerable attention. This review summarizes the calcification mechanism of biological valves and the research progress in anti-calcification modification strategies. Besides, the development of new polymeric valves is included, withThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Development Of Novel Polymeric Valvesmentioning

confidence: 99%

Prosthetic heart valves for transcatheter aortic valve replacement

Peng

et al. 2023

BMEMat

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“…Importantly, defined parameters and their bounds must be achievable experimentally. For example, tunable parameters for electrospun scaffolds can include material(s) modulus, fiber diameter, fiber orientation, graft thickness, pore size and porosity, and degradation kinetics. − It should be highlighted, however, that the use of formalized strategies of nondimensionalization (e.g., the Buckingham Pi theorem) can reduce the requisite number of physical parameters to explore in silico. In brief, these strategies provide an approach to identify and relate nondimensional groups from physical parameters in the experiment by defining fundamental dimensions (and scales) of length, mass, time, .…”

Section: Considerations For In Silico Testing and Optimizationmentioning

confidence: 99%

Model-Directed Design of Tissue Engineering Scaffolds

Cosgriff‐Hernandez

Timmins

2022

ACS Biomater. Sci. Eng.

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Scaffold-based tissue engineering requires a resorbable scaffold that can restore function and guide regeneration. Recent advances in material fabrication have expanded our control of compositional and architectural features to approach the complexity of native tissue. However, iterative scaffold design to balance multiple design targets toward optimizing regenerative performance remains both challenging and time-consuming. The number of design parameter combinations for scaffold manufacturing to achieve target properties is nearly limitless. Although a trial-and-error experimental approach may lead to a favorable scaffold design, the time and costs associated with such an approach are enormous. Computational optimization approaches are well suited to sample such a multidimensional design space and streamline the identification of target scaffold parameters for experimental evaluation. In this computational biomechanics approach, target fabrication parameters are identified by using a computational model to iterate across design parameter combinations (input) and predict the resulting graft properties (output). Herein, we describe the three key stages of this model-directed scaffold design: (1) model development, verification, and validation; (2) in silico optimization; and (3) model-directed scaffold fabrication and testing. Although there are several notable examples that have demonstrated the potential of this approach, additional accurate and physiologically appropriate computational simulations are needed to expand its utility across the field. In addition, continued advances in material fabrication are needed to provide the requisite control and resolution to produce the model-directed design. Finally, and most importantly, active collaboration between experts in materials science and computational modeling are critical to realize the full potential of this approach to accelerate scaffold development.

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“…The relatively high crosslink density of lower molecular weight acrylated PEG macromers (2-10 kDa) results in a brittle hydrogel with elongations less than 100%. 5 Decreasing the crosslink density of these networks via increased macromer molecular weight (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) results in increased extensibility but also reduced modulus and increased swelling. 87 Substrate stiffness of these networks is an important consideration given the established link to endothelial cell adhesion, spreading, and migration.…”

Section: Introductionmentioning

confidence: 99%