Quantum fluctuations of the electromagnetic field give rise to the force between parallel plates: the Casimir force. We theoretically calculate the Casimir force between two parallel isotropic plates when the space between the plates is filled with anisotropic material. Our result shows that the Casimir force, especially in the direction of the force, can be significantly affected by the anisotropy of the intervening material. We also discuss the combined influence of dispersion and anisotropy, and analyze the impact of the external electric filed on the Casimir force by affecting the anisotropy of the intervening material by Kerr electro-optical effect.