Aniridia associated with congenital aphakia and secondary glaucoma

Abstract

We report a case of aniridia associated with congenital aphakia and secondary glaucoma. A 35-year-old male presented with aniridia, congenital aphakia and secondary glaucoma in both eyes. After an unsuccessful medical management, he underwent trabeculectomy with mitomycin C and anterior vitrectomy under local anesthesia in his left eye. Postoperatively, at the end of six months, intraocular pressure (IOP) in his left eye was controlled without medications. This case highlights the rare association of aniridia with congenital aphakia and secondary glaucoma.

Rare association of familial aniridia, microcornea with myopia and aphakia

“…To the best of our knowledge, in the literature of aniridia association of aphakia has been very rarely reported. 6 In case II there was microspherophekic lens in BE.…”

Challenges in Surgical Intervention for a Rare Case of Anterior Segment Dysgenesis: A Case Report

“…In adult patients, it is difficult to treat congenital aniridia and its associated ocular comorbidities because it carries a significant risk of adverse events. 10 The outcomes and prognostic factors in congenital aniridia have been well described in several studies. According to a retrospective case series by Jacobson et al, the majority of aniridic patients underwent at least one intraocular surgery, with cataract, glaucoma, and keratopathy identified as key factors associated with worse visual acuity (VA).…”

“…8 Congenital aphakia is linked to FOXE3 gene mutations, and occurs between 1 to 5/10,000 live births. 9,10 While glasses or contact lenses can offer temporary correction, secondary implantation of an intraocular lens (IOL) has shown improved visual results. 11,12 Numerous IOL secondary implantation methods have been suggested over time, with options like scleral-fixated or iris-sutured posterior chamber IOL (PCIOLs), 13 but the best surgical approach remains uncertain.…”

Congenital Aniridia Associated with Congenital Aphakia and Glaucoma: A Case Report

“…1 However, the association of congenital aniridia with congenital aphakia is very rare and only three cases have been reported to date. [2][3][4] The chance of association between congenital aniridia and congenital aphakia has been estimated to be 1 in 490 million live births. Reported herein, is another patient of this very rare entity.…”