Anionic salts and dietary 25-hydroxyvitamin D stimulate calcium availability in steers

McGrath, J. J.; Savage, Darryl; Nolan, John; Rodgers, Nicholas; Elliott, Robert B.

doi:10.1017/s1751731112001887

Cited by 4 publications

(2 citation statements)

References 35 publications

(32 reference statements)

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“…Similarly, Las et al (2007) reported a drop in urine pH, as well as blood pH, in sheep after 4 d of consuminga negative DCAD diet. McGrath et al (2013) demonstrated that a -30 DCAD diet fed to beef steers effectively lowered urine pH after 10 d of supplementation and also observed increased urine Ca concentration in steers fed a -30 DCAD diet. Furthermore, Cho et al (2006) successfully increased blood Ca in beef cows by feeding a negative DCAD diet 6 to 20 d before slaughter.…”

Section: Resultsmentioning

confidence: 81%

Effect of decreasing dietary cation anion difference on feedlot performance, carcass characteristics, and beef tenderness1,2

Schoonmaker

Korn

Condron

et al. 2013

Journal of Animal Science

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The manipulation of acid-base balance has been extensively investigated as a means of manipulating Ca homeostasis and managing milk fever in dairy cows. A low dietary cation anion difference (DCAD) increases urinary Ca, blood-ionized Ca, and responsiveness to Ca-homeostatic hormones. Very little attention has been focused on the possibility of using a low dietary DCAD to increase muscle Ca availability, calpain activity, and meat tenderness of beef cattle. Thus, 90 Angus × Simmental crossbred steers were allotted by weight (590.1 ± 2.4 kg) and breed composition (% Simmental) to 3 treatments (6 pens/treatment, 5 steers/pen) to evaluate the effects of DCAD on beef tenderness. Treatments were initiated 2 wk before slaughter and consisted of 3 DCAD (mEq/100 g) treatments: -16, 0, and +16. Basal diets (DM basis) were 62 to 64% corn, 6 to 9% soybean meal, and 20% corn silage, and were formulated to contain similar concentrations of protein, energy (NEm; NEg), and minerals, with the exception of sodium and chlorine. A commercial chloride ion supplement (PASTURChlor, West Central, Ralston, IA) was added to diets to decrease DCAD and sodium bicarbonate was added to diets to increase DCAD. Performance before initiation of the study did not differ among treatments (P > 0.22). Urine pH did not differ at the initiation of the study (P > 0.57), but did increase at a decreasing rate on d 7 (6.37, 7.69, 8.13) and d 14 (5.68, 7.66, 8.03) of the study as DCAD increased from -16 to 0 to +16, respectively (quadratic, P < 0.02). Gain and gain:feed responded quadratically to DCAD (P < 0.01), increasing from -16 to 0 DCAD and decreasing from 0 to +16 DCAD. Hot carcass weight, dressing percent, fat thickness, LM area, yield grade, marbling score, quality grade distribution, 48 h muscle pH, and Ca content of muscle did not differ among treatments (P > 0.16). In addition, DCAD did not affect Warner-Bratzler shear force among treatments after 7 and 21 d of aging (P > 0.23). Although urine pH was decreased by feeding a -16 DCAD diet, Ca influx into the LM and beef tenderness were not affected by altering the DCAD in finishing beef cattle diets.

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Section: Resultsmentioning

confidence: 81%

Effect of decreasing dietary cation anion difference on feedlot performance, carcass characteristics, and beef tenderness1,2

Schoonmaker

Korn

Condron

et al. 2013

Journal of Animal Science

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“…McGrath et al. (2013) administered 3 mg 25‐OH‐D 3 /day to steers (18 months old and about 315 kg BW) fed diets with DCAD of 50 and 150 mEq/kg for 14 days. The 25‐OH‐D 3 increased urinary Ca excretion.…”

Section: Assessmentmentioning

confidence: 99%

Safety and efficacy of a feed additive consisting of 25‐hydroxycholecalciferol monohydrate produced with Saccharomyces cerevisiae CBS 146008 for all ruminants (DSM Nutritional Products Sp. z.o.o.)

Bampidis¹,

Azimonti²,

Bastos³

et al. 2023

EFS2

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Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of 25-hydroxycholecalciferol monohydrate produced with Saccharomyces cerevisiae CBS 146008 as a nutritional feed additive for all ruminants. The additive is already authorised for use with chickens for fattening, turkeys for fattening, other poultry and pigs. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concluded that the additive does not give raise to any safety concern regarding the production strain. The additive is safe for cattle for fattening and dairy cows at the maximum recommended use level of 0.1 mg 25-OH-D 3 /kg complete feed. This conclusion can be extended to other cattle categories and extrapolated to all ruminant species. The use of 25-OH-D 3 in all ruminants under the proposed conditions of use is considered safe for the consumer. The additive is not irritant to the skin or eyes. No conclusion on its potential to be a skin sensitiser or on its effects on the respiratory system can be reached due to absence of data. The use of the additive under assessment at the recommended conditions of use is considered safe for the environment. 25-OH-D 3 is an efficient source of vitamin D 3 for all ruminants when used according to the proposed conditions of use.

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Managing plasma P concentrations in beef heifers with a slow release vitamin D supplementation

Tomkins

Elliott²,

McGrath³

et al. 2020

Anim. Prod. Sci.

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Context In extensive northern grazing systems, supplementation of P is recommended to maximise cattle growth rates and reproduction. Improving the absorption of P for the animal by influencing metabolic pathways has the potential to improve both the productivity and profitability of extensive livestock enterprises. Aims This study evaluated the efficacy of rumen bolus containing 25-hydroxyvitamin D (25OHD), commercially available as Hy-D®, and/or monensin on blood P and Ca concentrations in young cattle. Methods A total of 84 heifers, initial liveweight (mean ± s.e.m.) 184 ± 2.0 kg, were allocated to four groups, dosed with one of four slow release bolus: (1) placebo (control), (2) monensin (120 mg/day), (3) Hy-D® (6 mg/day), or (4) monensin with Hy-D®, and managed on a common unimproved native pasture from August 2012 to February 2013. On four occasions postdosing, liveweight, hip height and body condition scores were recorded, and individual faecal and jugular blood samples were collected. Key results Supplementation with monensin had a significant effect (P < 0.05) on average daily gains for the first 25 days. Interactions between 25OHD and monensin and time × monensin were also significant (P < 0.05). After 188 days, heifers receiving monensin or 25OHD + monensin were 5 and 10 kg heavier respectively, compared with their counterparts in the control and 25OHD groups. Plasma P concentrations at 25 days were 6.6 mg/dL, then increased to between 8.5 and 9.0 mg/dL and maintained this level for up to 109 days with a bolus releasing 6.0 mg/day 25OHD. Conclusions The study demonstrated that sustained and elevated plasma concentrations of both 25OHD and P, compared with control animals, can be achieved. The slow release rumen bolus maintained an elevated plasma concentration of 25OHD, and indicated that a target plasma concentration for 25OHD for increasing P absorption in beef cattle is between 200 and 300 ng/mL. Implications Supplementation of a metabolite of vitamin D influences P metabolism in Brahman heifers under grazing conditions. Integration with standard supplementation practices would optimise growth rates and reproductive performance.

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Anionic salts and dietary 25-hydroxyvitamin D stimulate calcium availability in steers

Cited by 4 publications

References 35 publications

Effect of decreasing dietary cation anion difference on feedlot performance, carcass characteristics, and beef tenderness1,2

Effect of decreasing dietary cation anion difference on feedlot performance, carcass characteristics, and beef tenderness1,2

Safety and efficacy of a feed additive consisting of 25‐hydroxycholecalciferol monohydrate produced with Saccharomyces cerevisiae CBS 146008 for all ruminants (DSM Nutritional Products Sp. z.o.o.)

Managing plasma P concentrations in beef heifers with a slow release vitamin D supplementation

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