Anionic lipid vesicles have differential effects on the aggregation of early onset-associated α-synuclein missense mutants

Structural characterisation of α-synuclein–membrane interactions and the resulting aggregation using small angle scattering

“…The fact that both length and thickness of the fibrils were found to increase over time is in agreement with previous findings for the α-synuclein–DMPS system, for which electron microscopic imaging revealed the presence of polydisperse mixtures of different types of fibrils. 62,63 At t = 2 min, the data indicate the presence of rods with R = 18 Å and L = 210 Å. Between 1 and 4 hours, there is a significant upturn at low- q in the data that cannot be captured by the single-state cylindrical form factor.…”