Anion Receptor Chemistry

Gale, Philip A.; Howe, Ethan N.W.; Wu, Xin

doi:10.1016/j.chempr.2016.08.004

Cited by 376 publications

(240 citation statements)

References 115 publications

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“…1 Even after decades of research, there are few supramolecular hosts that can bind anions in water, and fewer still that can achieve selective recognition in this medium. 2 …”

Section: Introductionmentioning

confidence: 99%

Supramolecular anion recognition in water: synthesis of hydrogen-bonded supramolecular frameworks

et al. 2017

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“…1 Even after decades of research, there are few supramolecular hosts that can bind anions in water, and fewer still that can achieve selective recognition in this medium. 2 …”

Section: Introductionmentioning

confidence: 99%

Supramolecular anion recognition in water: synthesis of hydrogen-bonded supramolecular frameworks

et al. 2017

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“…This information would be key to understanding the interplay between receptor lipophilicity and anion binding in through-membrane transporters and channels. 95 Cations Cations display weaker Hofmeister phenomena, 96 and this may hinder a thorough understanding of their solvation and properties. In supramolecular chemistry, cation recognition has a long history dating back to Pedersen's crown ethers; a family of hosts that were themselves based on the earlier macrocyclic Schiff bases designed for binding transition metal cations.…”

Section: [Insert Figure 3]mentioning

confidence: 99%

Collaborative routes to clarifying the murky waters of aqueous supramolecular chemistry

et al. 2017

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Collaborative routes to clarifying the murky waters of aqueous supramolecular chemistry. AbstractOn planet Earth, water is everywhere: the majority of the surface is covered with it; it is a key component of all life; its vapor and droplets fill the lower atmosphere; even rocks contain it and undergo geomorphological changes because of it. A community of physical scientists largely drives studies of the chemistry of water and aqueous solutions, with expertise in biochemistry, spectroscopy, and computer modeling. More recently however, supramolecular chemistry -with its expertise in macrocyclic synthesis and measuring supramolecular interactions -have renewed their interest in water-mediated non-covalent interactions. These two groups offer complementary expertise that, if harnessed, offers to accelerate our understanding of aqueous supramolecular chemistry and water writ large. This review summarizes the state-of-the-art of the two fields, and highlights where there is latent chemical space for collaborative exploration by the two groups. 4Water is ubiquitous and essential to life on planet Earth. A full understanding of aqueous solutions is therefore of significance to a wide range of fields within the atmospheric, environmental, biological and geological sciences. Within the chemical sciences, a deeper appreciation of how non-covalent interactions and chemical transformations are influenced by water would benefit a variety of fields. However, as we highlight here, there are many open questions regarding the chemical and physical properties of aqueous solutions.The aqueous realm is frequently bifurcated into the Hofmeister and hydrophobic effects, phenomena that respectively deal with the properties of solutions of salts and relatively nonpolar molecules. However, it is becoming increasingly evident that these areas do in fact frequently overlap; two prime examples being the accumulation of large polarizable anions at the air-water interface, 1-5 and the favorable interactions of polarizable anions with non-polar surfaces. [6][7][8][9][10][11][12][13][14][15] Thus the hydrophobic and Hofmeister effects are but part of a greater continuum of aqueous supramolecular chemistry, with many important and outstanding questions regarding the influence of the different kinds of non-covalent interactions involved.Studies of water and aqueous solutions have mostly been driven by the physical sciences community, a broad range of scientists whose expertise in spectroscopy, computer modeling, and biochemistry (to name just three areas) has generally not involved macrocycles or host molecules in general. However, for some time now, supramolecular chemists -with their expertise in macrocyclic synthesis and measuring weak non-covalent interactions -have been travelling a parallel course of exploration. This Review, inspired by discussions between sixteen members of each community at a recent workshop, 16 is an attempt to summarize what we know about aqueous solutions, what we do not know about them, and where the two communit...

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“…Many other effective transporters are known and very recently one acted as an inhibitor of autophagy [23]. Several classes of anion transporters have been the subject of separate reviews [24,25]. …”

Section: Introductionmentioning

confidence: 99%

Pyrrole N–H anion complexes

Vargas‐Zúñiga

Sessler

2017

Coordination Chemistry Reviews

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Synthetic pyrrole-based anion receptors date back to the 1990s. They have been extensively developed in the context of macrocyclic systems as expanded porphyrins and calixpyrroles, and related systems. The chemistry of open-chain pyrrolic systems is, in many respects, no less venerable. It also has more direct analogy to naturally occurring pyrrole-based anion binding motifs. However, it has not been the subject of a comprehensive review. Presented herein is a summary of efforts devoted to the creation of de novo pyrrole-based receptors, as well as the anion recognition chemistry of naturally occurring pyrrolic systems as prodigiosins and their synthetic analogues.

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Anion Receptor Chemistry

Cited by 376 publications

References 115 publications

Supramolecular anion recognition in water: synthesis of hydrogen-bonded supramolecular frameworks

Supramolecular anion recognition in water: synthesis of hydrogen-bonded supramolecular frameworks

Collaborative routes to clarifying the murky waters of aqueous supramolecular chemistry

Pyrrole N–H anion complexes

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