Anion Gap Determination in Preeclampsia

Reference Intervals for Anion Gap and Strong Ion Difference in Pregnancy: A Pilot Study

“…However, at the multi-compartment level (total body physiology), interaction between the control systems regulating the three independent variables does occur. For example, there is evidence to support the hypothesis of interaction between SID and both PCO 2 and total protein that is mediated by changes in plasma Cl (12,13).…”

“…We studied 112 women during pregnancy or postpartum in a cross-sectional fashion (6 first trimester, [weeks [6][7][8][9][10][11][12], 47 mid-trimester [weeks [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28], 59, third trimester [weeks 29 to term], and 13 women postpartum). Normotensive healthy subjects undergoing uneventful pregnancies were recruited consecutively during routine prenatal clinic visits; exclusions included a history or presence of hypertension, diabetes, renal disease, and disorders requiring the chronic use of medications.…”

“…However, these changes do not seem to have been explored in relation to the methodological advances in measuring electrolytes, and to the conceptual development in our understanding of the interrelationship between PCO 2 , electrolytes and weak acids to pH, HCO 3 , and anion gap. We could locate only limited reports on the anion gap in "normal" pregnancy, the published studies limited to hospitalised populations (11,12). Literature is even sparser regarding SID data during gestation (13,14).…”

Strong ion and weak acid analysis in severe preeclampsia: potential clinical significance

“…As in previous investigations on acid-base status in preeclampsia, these authors focused mainly on describing plasma pH, HCO 3 , base excess (BE) or the anion gap (AG). [10][11][12] Although sufficient to simply describe an alteration in acid/base status in uncomplicated patients, in critically ill patients simultaneous acid/base derangements may offset each other and ultimately lead to a minimally deranged pH, HCO 3 , BE and AG. [13][14][15][16] Thus conventional analysis may overlook important and informative pathologic processes.…”