Anion Assisted Synthesis of Large Pore Hollow Dendritic Mesoporous Organosilica Nanoparticles: Understanding the Composition Gradient

Yang, Yannan; Bernardi, Stefano; Song, Hao; Zhang, Jun; Yu, Meihua; Reid, James C.; Strounina, Ekaterina; Searles, Debra J.; Yu, Chengzhong

doi:10.1021/acs.chemmater.5b03963

Cited by 210 publications

(179 citation statements)

References 27 publications

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“…[65] Nanostructures engineered on the shell of silica hollow spheres, such as mesopores [66] and surface roughness, [67] are usually recognized rather important for biomedical applications, as it is the surface of a nanoparticle that first interacts with biomolecules/biosystems. [65] Nanostructures engineered on the shell of silica hollow spheres, such as mesopores [66] and surface roughness, [67] are usually recognized rather important for biomedical applications, as it is the surface of a nanoparticle that first interacts with biomolecules/biosystems.…”

Section: Silica Hollow Spheresmentioning

confidence: 99%

Electron Tomography: A Unique Tool Solving Intricate Hollow Nanostructures

et al. 2018

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Innovations in nanofabrication have expedited advances in hollow-structured nanomaterials with increasing complexity, which, at the same time, set challenges for the precise determination of their intriguing and complicated 3D configurations. Conventional transmission electron microscopy (TEM) analysis typically yields 2D projections of 3D objects, which in some cases is insufficient to reflect the genuine architectures of these 3D nano-objects, providing misleading information. Advanced analytical approaches such as focused ion beam (FIB) and ultramicrotomy enable the real slicing of nanomaterials, realizing the direct observation of inner structures but with limited spatial discrimination. Electron tomography (ET) is a technique that retrieves spatial information from a series of 2D electron projections at different tilt angles. As a unique and powerful tool kit, this technique has experienced great advances in its application in materials science, resolving the intricate 3D nanostructures. Here, the exceptional capability of the ET technique in the structural, chemical, and quantitative analysis of hollow-structured nanomaterials is discussed in detail. The distinct information derived from ET analysis is highlighted and compared with conventional analysis methods. Along with the advances in microscopy technologies, the state-of-the-art ET technique offers great opportunities and promise in the development of hollow nanomaterials.

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Section: Silica Hollow Spheresmentioning

confidence: 99%

Electron Tomography: A Unique Tool Solving Intricate Hollow Nanostructures

et al. 2018

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“…Results showed that the hydrophobic modification of the roughness surface enhanced the protein adsorption capacity and improved the cellular uptake performance. [123] Results demonstrated that the DHMSNs possessed higher loading capacity of BSA and lower hemolytic activity than DMSNs, showing great potential in delivering large biomolecules. In order to control the protein release at specific environment (e.g., acidic pH and glucose) or avoid the loss of biomolecules over time, those proteins could be modified on the surface with specific linkage.…”

Section: Silica Nanoparticlesmentioning

confidence: 96%

Section: Silica Nanoparticlesmentioning

confidence: 99%

“…e) Aldehyde-functionalized dendritic MSNs. [123] Copyright 2016, American Chemical Society. [119] Copyright 2016, Elsevier B.V. f) GSH-responsive biodegradable dendritic mesoporous organosilica nanoparticles.…”

Section: Silica Nanoparticlesmentioning

confidence: 99%

“…The proteins could be immobilized in the void spaces of rough surface. [121,123] For example, Yu and co-workers reported a anion assisted approach to synthesize DMSNs with the pore size of 29.5 nm. [124,136,137] Using the chemical modification method to connect the proteins with the silica nanoparticles is another powerful way to deliver the proteins to the target site.…”

Section: Silica Nanoparticlesmentioning

confidence: 99%

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Rational Design of Nanocarriers for Intracellular Protein Delivery

et al. 2019

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Protein/antibody therapeutics have exhibited the advantages of high specificity and activity even at an extremely low concentration compared to small molecule drugs. However, they are accompanied by unfavorable physicochemical properties such as fragile tertiary structure, large molecular size, and poor penetration of the membrane, and thus the clinical use of protein drugs is hindered by inefficient delivery of proteins into the host cells. To overcome the challenges associated with protein therapeutics and enhance their biopharmaceutical applications, various protein‐loaded nanocarriers with desired functions, such as lipid nanocapsules, polymeric nanoparticles, inorganic nanoparticles, and peptides, are developed. In this review, the different strategies for intracellular delivery of proteins are comprehensively summarized. Their designed routes, mechanisms of action, and potential therapeutics in live cells or in vivo are discussed in detail. Furthermore, the perspective on the new generation of delivery systems toward the emerging area of protein‐based therapeutics is presented as well.

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