Animal testing in the history of anesthesia: Now and then, some stories, some facts

Goyal, Rakhee

doi:10.4103/0970-9185.155139

Cited by 7 publications

(5 citation statements)

References 8 publications

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“…publications. Although animal studies generate lower-grade scientific evidence, they are essential to the development of A.C.C.M.. For example, animal research played an essential role in developing the Guedel cannula, curarisation, and motor blocks [ 31 ]. Africa’s rich biodiversity and ethnopharmacology are likely to house the next essential drug in A.C.C.M [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Systematic review and bibliometric analysis of African anesthesia and critical care medicine research part I: hierarchy of evidence and scholarly productivity

et al. 2020

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Background Research is an essential component of Anesthesia, and the contributions of researchers and institutions can be appreciated from the analysis of scholarly outputs. Such analyses help identify major contributors and trends in publication. Little is known about the state of Anesthesia and Critical Care Medicine (A.C.C.M.) research in Africa. We aimed to describe African A.C.C.M. research’s current landscape by determining its productivity per country and point towards possible ideas for improvement. Methods The authors searched PubMed, Embase, Web of Science, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) from inception to May 4, 2020, for articles on or about A.C.C.M. in Africa. Studies were selected based on their titles and abstracts. Rayyan software was later on used for data management in the review selection process. Then, the full-text of eligible articles were screened. Data were extracted, and the number of articles per physician anesthesia providers and provider density were calculated. Kruskal Wallis test and Spearman’s correlation were used, and a P-value < 0.05 was considered statistically significant. Results Of the 4690 articles, only 886 (18.9%) were included in the analysis. The articles were published between 1946 and 2020 in 278 target journals. 55 (6.2%) articles were published in the South African Journal of Surgery, 51 (5.8%) in Anesthesia and Analgesia, and 46 (5.2%) in Anaesthesia. 291 (32.8%) studies were cross-sectional. 195 (22.0%) first authors were from Nigeria, 118 (13.3%) from South Africa, and 88 (9.9%) from the U.S.A. Malawi (1.67), Togo (1.06), and Sierra Leone (1.00) had the highest number of articles per provider. Whereas Ethiopia (580.00), Nigeria (336.21), and Malawi (333.33) had the highest number of articles per provider density. Conclusion We identified the most and least productive African countries in A.C.C.M. research and a low-quality hierarchy of evidence in these publications. Hence, the study’s findings may aid in driving the A.C.C.M. research agenda and capacity building in Africa.

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Section: Discussionmentioning

confidence: 99%

Systematic review and bibliometric analysis of African anesthesia and critical care medicine research part I: hierarchy of evidence and scholarly productivity

et al. 2020

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“…Although animal studies generate lower-grade scienti c evidence, they are essential to the development of A.C.C.M.. For example, animal research played an essential role in developing the Guedel cannula, curarisation, and motor blocks. [31] Africa's rich biodiversity and ethnopharmacology are likely to house the next essential drug in A.C.C.M.. [32] This untapped potential could lead to the discovery and production of more affordable drugs for African patients. Unfortunately, African basic science researchers face more barriers than clinical researchers.…”

Section: Hierarchy Of Evidencementioning

confidence: 99%

Systematic review and bibliometric analysis of African anesthesia and critical care medicine research Part I: Hierarchy of evidence and scholarly productivity

Kanmounye

Tochie²,

Mbonda³

et al. 2020

Preprint

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Background: Research is an essential component of Anesthesia, and the contributions of researchers and institutions can be appreciated from the analysis of scholarly outputs. Such analyses help identify major contributors and trends in publication. Little is known about the state of Anesthesia and Critical Care Medicine (A.C.C.M.) research in Africa. We aimed to describe African A.C.C.M. research's current landscape by determining its productivity per country and point towards possible ideas for improvement. Methods: The authors searched PubMed, Embase, Web of Science, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) from inception to May 4, 2020, for articles on or about A.C.C.M. in Africa. Studies were selected based on their titles and abstracts. Rayyan software was later on used for data management in the review selection process. Then, the full-text of eligible articles were screened. Data were extracted, and the number of articles per physician anesthesia providers and provider density were calculated. Kruskal Wallis test and Spearman's correlation were used, and a P-value <0.05 was considered statistically significant.Results: Of the 4690 articles, only 886 (18.9%) were included in the analysis. The articles were published between 1946 and 2020 in 278 target journals. 55 (6.2%) articles were published in the South African Journal of Surgery, 51 (5.8%) in Anesthesia and Analgesia, and 46 (5.2%) in Anaesthesia. 291 (32.8%) studies were cross-sectional. 195 (22.0%) first authors were from Nigeria, 118 (13.3%) from South Africa, and 88 (9.9%) from the U.S.A. Malawi (1.67), Togo (1.06), and Sierra Leone (1.00) had the highest number of articles per provider. Whereas Ethiopia (580.00), Nigeria (336.21), and Malawi (333.33) had the highest number of articles per provider density. Conclusion: We identified the most and least productive African countries in A.C.C.M. research and a low-quality hierarchy of evidence in these publications. Hence, the study's findings may aid in driving the A.C.C.M. research agenda and capacity building in Africa.

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“…For example, animal research played an essential role in the development of the Guedel cannula, curarisation, and motor blocks. [29] Africa's rich biodiversity and ethnopharmacology are likely to house the next essential drug in ACCM. [30] This untapped potential could lead to the discovery and production of more affordable drugs for African patients.…”

Section: Hierarchy Of Evidencementioning

confidence: 99%

Systematic Review and Bibliometric Analysis of African Anesthesia and Critical Care Medicine Research Part I: Hierarchy of Evidence and Scholarly Productivity

Kanmounye

Tochie²,

Mbonda³

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundResearch is an essential component of Anesthesia, and the contributions of researchers and institutions can be appreciated from the analysis of scholarly outputs. Such analyses help identify major contributors and trends in publication. Little is known about the state of Anesthesia and Critical Care Medicine (ACCM) research in Africa. In this study, the authors analyzed the study designs and contributions to ACCM research in Africa.MethodsThe authors searched PubMed, Embase, Web of Science, and CINAHL from inception to May 4, 2020, for articles on or about ACCM in Africa. The titles and abstracts of the articles were screened first on Rayyan. Then, the full-text of eligible articles were screened. Data were extracted, and the number of articles per physician anesthesia providers and provider density were calculated. Kruskal Wallis test and Spearman's correlation were used, and a P-value <0.05 was considered to be statistically significant.ResultsOf the 4690 articles, only 886 (18.9%) were included in the analysis. The articles were published between 1946 and 2020 in 278 target journals. 55 (6.2%) articles were published in the South African Journal of Surgery, 51 (5.8%) in Anesthesia and Analgesia, and 46 (5.2%) in Anaesthesia. 291 (32.8%) studies were cross-sectional. 195 (22.0%) first authors were from Nigeria, 118 (13.3%) from South Africa, and 88 (9.9%) from the USA. Malawi (1.67), Togo (1.06), and Sierra Leone (1.00) had the highest number of articles per provider. Whereas Ethiopia (580.00), Nigeria (336.21), and Malawi (333.33) had the highest number of articles per provider density. ConclusionThe results reported in this study highlight contributions of Africans and the hierarchy of evidence in African anesthesiology research and critical care medicine. These results may aid in setting the research agenda.

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Animal testing in the history of anesthesia: Now and then, some stories, some facts

Cited by 7 publications

References 8 publications

Systematic review and bibliometric analysis of African anesthesia and critical care medicine research part I: hierarchy of evidence and scholarly productivity

Systematic review and bibliometric analysis of African anesthesia and critical care medicine research part I: hierarchy of evidence and scholarly productivity

Systematic review and bibliometric analysis of African anesthesia and critical care medicine research Part I: Hierarchy of evidence and scholarly productivity

Systematic Review and Bibliometric Analysis of African Anesthesia and Critical Care Medicine Research Part I: Hierarchy of Evidence and Scholarly Productivity

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