Animal studies in clinical MRI scanners: A custom setup for combined fMRI and deep-brain stimulation in awake rats

Derksen, Maik; Rhemrev, Valerie; Veer, Marijke van der; Jolink, Linda; Zuidinga, Birte; Mulder, Tosca; Reneman, Liesbeth; Nederveen, Aart J.; Feenstra, Matthijs G.P.; Willuhn, Ingo; Denys, Damiaan

doi:10.1016/j.jneumeth.2021.109240

Cited by 7 publications

(5 citation statements)

References 33 publications

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“…There have been several publications on the construction of RF coils and restraining systems for awake MRI imaging in rats ( Martin et al, 2013 ; Chang J. B. et al, 2016 ; Madularu et al, 2017a ; Stenroos et al, 2018 ; Derksen et al, 2021 ), mice ( Ferris et al, 2014 ; Madularu et al, 2017b ; Tsurugizawa et al, 2021 ), and the common marmoset monkey ( Papoti et al, 2013 , 2017 ; Schaeffer et al, 2019 ; Ziegler et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Applications in Awake Animal Magnetic Resonance Imaging

Ferris

2022

Front. Neurosci.

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There are numerous publications on methods and applications for awake functional MRI across different species, e.g., voles, rabbits, cats, dogs, and rhesus macaques. Each of these species, most obviously rhesus monkey, have general or unique attributes that provide a better understanding of the human condition. However, much of the work today is done on rodents. The growing number of small bore (≤30 cm) high field systems 7T- 11.7T favor the use of small animals. To that point, this review is primarily focused on rodents and their many applications in awake function MRI. Applications include, pharmacological MRI, drugs of abuse, sensory evoked stimuli, brain disorders, pain, social behavior, and fear.

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Section: Introductionmentioning

confidence: 99%

Applications in Awake Animal Magnetic Resonance Imaging

Ferris

2022

Front. Neurosci.

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“…The use of clinical scanners to conduct preclinical research also benefits from the hardware and software advancements continuously being made in modern clinical MRI systems, such as RF coil technology, 1 gradient coil technology, 8 deep‐brain stimulation technology, 9 and molecular imaging technology 10 . Moreover, many laboratories and clinical research groups struggle to access dedicated animal systems, whereas clinical whole‐body scanners are often more readily available 9,11 …”

Section: Introductionmentioning

confidence: 99%

“…1 The use of clinical scanners to conduct preclinical research can facilitate a more direct comparison with clinical studies, accelerate the development of clinically applicable imaging protocols, improve the matching of field strength-related mechanisms such as relaxation, and provide evidence to support the clinical relevance of functional MRI data/biomarkers. [2][3][4][5][6][7] The use of clinical scanners to conduct preclinical research also benefits from the hardware and software advancements continuously being made in modern clinical MRI systems, such as RF coil technology, 1 gradient coil technology, 8 deep-brain stimulation technology, 9 and molecular imaging technology. 10 Moreover, many laboratories and clinical research groups struggle to access dedicated animal systems, whereas clinical whole-body scanners are often more readily available.…”

Section: Introductionmentioning

confidence: 99%

“…10 Moreover, many laboratories and clinical research groups struggle to access dedicated animal systems, whereas clinical whole-body scanners are often more readily available. 9,11 High-quality magnetic field homogeneity is an essential prerequisite for most MRI applications. Unfortunately, the homogenization of magnetic field distributions of the rat brain is a difficult task.…”

Section: Introductionmentioning

confidence: 99%

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A 5‐channel local B₀ shimming coil combined with a 3‐channel RF receiver coil for rat brain imaging at 3 T

Chen

Luo

Tie

et al. 2022

Magnetic Resonance in Med

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Purpose We aimed to improve B0 magnetic field homogeneity and minimize the interference between RF coils and local B0 shimming coils with few channel numbers. Methods To design and construct the prototype for B0 shimming of the rat brain, we first evaluated the interferences of single shimming loops on RF receiver loops. Then, B0 shimming of the whole rat brain was implemented using an optimization procedure. The positions and currents of the local shimming coils with channel numbers from 3 to 6 were optimized to improve shimming performance. Based on the simulation results, a 5‐channel local shimming coil, combined with a 3‐channel RF receiver coil, was constructed and evaluated by animal experiments. Results There was marginal SNR loss within 5% after integrating the local shimming coil into the RF receiver coil. With respect to the Siemens standard shims up to second order, the B0 inhomogeneity in one whole rat brain was reduced from 39.6 Hz to 24.7 Hz by using the local shimming coil. A large portion of the EPI distortions was recovered after using the 5‐channel local shimming coil. The temporal SNR using the local shimming coil was higher than that using the Siemens standard shims up to second order, with an improvement of more than 24%. Conclusions The local shimming coil can improve B0 magnetic field homogeneity despite minor effects on the RF coil and can benefit a variety of applications that are sensitive to B0 inhomogeneity. Nevertheless, EPI for rat brain is still very challenging.

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“…For DBS studies in rodents, 140 μm diameter braided platinum/iridium wire electrodes ( Van De Berg, 2015 ), 200 μm diameter braided stainless steel wires ( Morimoto et al, 2011 ) and 250 μm braided silver wires have been used for DBS protocols in conjunction with simultaneous MRI and EEG acquisitions. Platinum/iridium and stainless steel electrodes induce a susceptibility artifact of twice the original electrode diameter and silver electrodes do not increase the artifact compared to the electrode diameter, but there is more signal around the longitudinal diameter of the electrode ( Dunn et al, 2009 ; Young et al, 2011 ; Derksen et al, 2021 ). Carbon fiber electrodes have been used in neuroscience as an option for recording ( Chuapoco et al, 2019 ; Joshi-Imre et al, 2019 ) and stimulating brain regions ( Gallino et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Focal electrical stimulation on an alcohol disorder model using magnetic resonance imaging-compatible chronic neural monopolar carbon fiber electrodes

López-Castro

Ángeles-Valdez²,

Rojas-Piloni³

et al. 2022

Front. Neurosci.

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Neuromodulation interventions, such as Deep Brain Stimulation (DBS) and repeated transcranial magnetic stimulation (rTMS), are proposed as possible new complementary therapies to treat substance use disorders (SUD) such as alcohol use disorder (AUD). It is hypothesized that neuromodulation may induce neural plasticity in the reward and frontostriatal systems via electrical field induction, possibly reducing symptoms. Preclinical self-administration rodent models of AUD may help us gain insight into the effects of neuromodulation therapies on different pathology, as well as the neural mechanisms behind the positive effects. DBS, or any type of brain stimulation using intracranial electrodes in rodents, would benefit from the use of magnetic resonance imaging (MRI) to study the longitudinal effects and mechanisms of stimulation as well as novel targets, as it is a non-invasive technique that allows the analysis of structural and functional changes in the brain. To do this, there is a need for MRI-compatible electrodes that allow for MRI acquisition with minimal distortion of the magnetic field. In this protocol, we present a method for the construction and surgery of chronically implantable monopolar carbon electrodes for use in rats. Unlike conventional electrodes, carbon electrodes are resistant to high temperatures, flexible, and generate fewer artifacts in MRI compared to conventional ones. We validated its use by using a focal electrical stimulation high-frequency (20 Hz) protocol that lasted ∼10 sessions. We propose that this technique can also be used for the research of the neurophysiological bases of the neuromodulatory treatment in other preclinical substance use disorders (SUD) models.

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Animal studies in clinical MRI scanners: A custom setup for combined fMRI and deep-brain stimulation in awake rats

Cited by 7 publications

References 33 publications

Applications in Awake Animal Magnetic Resonance Imaging

Applications in Awake Animal Magnetic Resonance Imaging

A 5‐channel local B₀ shimming coil combined with a 3‐channel RF receiver coil for rat brain imaging at 3 T

Focal electrical stimulation on an alcohol disorder model using magnetic resonance imaging-compatible chronic neural monopolar carbon fiber electrodes

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Animal studies in clinical MRI scanners: A custom setup for combined fMRI and deep-brain stimulation in awake rats

Cited by 7 publications

References 33 publications

Applications in Awake Animal Magnetic Resonance Imaging

Applications in Awake Animal Magnetic Resonance Imaging

A 5‐channel local B0 shimming coil combined with a 3‐channel RF receiver coil for rat brain imaging at 3 T

Focal electrical stimulation on an alcohol disorder model using magnetic resonance imaging-compatible chronic neural monopolar carbon fiber electrodes

Contact Info

Product

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A 5‐channel local B₀ shimming coil combined with a 3‐channel RF receiver coil for rat brain imaging at 3 T