Animal spongiform encephalopathies ‐ an update

Schreuder, B. E. C.

doi:10.1080/01652176.1994.9694445

Cited by 14 publications

(1 citation statement)

References 54 publications

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“…In 1990, the first cases of BSE in cattle were diagnosed in continental Europe (Schreuder 1994), and cases were subsequently diagnosed in nearly all the then member states of the EU and some accession countries. Some of these cases could be traced back to animals imported from the UK, but most occurred in locally born cattle.…”

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confidence: 99%

Inactivation of transmissible spongiform encephalopathy agents during the manufacture of dicalcium phosphate from bone

Grobben¹,

Steele

Somerville

et al. 2006

Veterinary Record

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Dicalcium phosphate was prepared from industrial crushed bone artificially contaminated with transmissible spongiform encephalopathy agents in two experiments carried out in an accurately scaled-down laboratory model of the industrial manufacturing process. In one experiment, 10 g of mouse brain infected with the 301V strain of mouse-passaged bovine spongiform encephalopathy agent was added to the crushed bone; in the other experiment, 10 g of hamster brain infected with the 263K strain of hamster-passaged scrapie agent was added. Samples of the infectious brain and dried dicalcium phosphate were assayed for the amount of 301V or 263K infectivity present. The titre of infectivity of the 301V-infected brain was 10(7.7) intracerebral ID50/g; that of the 263K-infected brain was 10(8.0) intracerebral ID50/g. The titres of the dried samples of dicalcium phosphate were 10(2.5) ID50/g in the experiment spiked with 301V and 10(2.7) ID50/g in the experiment spiked with 263K. The calculated clearance factors were 10(3.9) for the experiment with 301V and 10(3.8) for the experiment with 263K.

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confidence: 99%