2012
DOI: 10.1007/s00281-012-0315-y
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Animal models to study gluten sensitivity

Abstract: The initial development and maintenance of tolerance to dietary antigens is a complex process that, when prevented or interrupted, can lead to human disease. Understanding the mechanisms by which tolerance to specific dietary antigens is attained and maintained is crucial to our understanding of the pathogenesis of diseases related to intolerance of specific dietary antigens. Two diseases that are the result of intolerance to a dietary antigen are celiac disease (CD) and dermatitis herpetiformis (DH). Both of … Show more

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Cited by 29 publications
(18 citation statements)
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“…1,21 In healthy individuals, the immune system, through innate and adaptive immunity, plays a central role in the maintenance of tolerance to dietary antigens and other potential harmful pathogens, thus protecting the organism from the development of diseases. 22 The innate immune response is immediate and fast, including both cellular and humoral components. 23 Several cells are involved, including macrophages, neutrophils, dendritic cells, monocytes, mast cells and natural killer T cells, expressing both natural killer receptors and CD1d-restricted ab-T-cell receptors.…”
Section: Basic Immunological Mechanisms and Pathogenesismentioning
confidence: 99%
“…1,21 In healthy individuals, the immune system, through innate and adaptive immunity, plays a central role in the maintenance of tolerance to dietary antigens and other potential harmful pathogens, thus protecting the organism from the development of diseases. 22 The innate immune response is immediate and fast, including both cellular and humoral components. 23 Several cells are involved, including macrophages, neutrophils, dendritic cells, monocytes, mast cells and natural killer T cells, expressing both natural killer receptors and CD1d-restricted ab-T-cell receptors.…”
Section: Basic Immunological Mechanisms and Pathogenesismentioning
confidence: 99%
“…In vitro approaches including intestinal biopsy organ culture and cell lines were advantageous, however nowadays animal models provide much information. Different species have been used as animal model of CD including dogs, horses, monkeys, rats, rabbits and mice, even if none mimics all the features of the disease (Marietta and Murray 2012; Schuppan et al 2009; Stoven et al 2013). Gluten sensitive rhesus macaques are good for testing new therapies as the applicability of the barley endoprotease, EP-B2 (Bethune et al 2008) and new-born rats sensitised with INF-γ and fed gliadin evaluated the administration of a Bifidum strain (Laparra et al 2013).…”
Section: Discussionmentioning
confidence: 99%
“…The potential utility of mouse models in basic and applied biomedical research is well appreciated [30,31,32]. Along with previous mouse models of gliadin sensitivity, our new model of SSWP hypersensitivity with additional clinical (i.e., dermatitis) and mediator (i.e., mMCP-1) phenotypes should provide a novel opportunity for further research and development.…”
Section: Discussionmentioning
confidence: 99%