Animal Models of Sudden Infant Death Syndrome

Blood‐Siegfried, Jane

doi:10.1007/978-1-59745-285-4_60

Cited by 1 publication

(2 citation statements)

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“…Given this difficulty, animal models can be beneficial when studying the underlying mechanism of SIDS. However, no known in vivo model fully reflects the genetic, developmental, and environmental risk factors associated with SIDS identified in prior epidemiological and clinical investigations [8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

“…Animal models can be beneficial for investigating the underlying mechanism of SIDS; however, there is no known in vivo model that adequately reflects the genetic, developmental, and environmental risk factors related to SIDS discovered in previous epidemiological and clinical studies. Animal models, albeit not providing a definitive explanation, do offer reliability to some hypotheses concerning the aetiology of SIDS and might help clarify (at least in part) the discrepancies between certain parts of the literature findings [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and Sudden Infant Death Syndrome: A Potential Model for Investigation

Tóth,

Simon,

Reglődi

2023

IJMS

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Sudden infant death syndrome (SIDS) represents a significant cause of post-neonatal mortality, yet its underlying mechanisms remain unclear. The triple-risk model of SIDS proposes that intrinsic vulnerability, exogenous triggers, and a critical developmental period are required for SIDS to occur. Although case–control studies have identified potential risk factors, no in vivo model fully reflects the complexities observed in human studies. Pituitary adenylate cyclase-activating polypeptide (PACAP), a highly conserved neuropeptide with diverse physiological functions, including metabolic and thermal regulation, cardiovascular adaptation, breathing control, stress responses, sleep–wake regulation and immunohomeostasis, has been subject to early animal studies, which revealed that the absence of PACAP or its specific receptor (PAC1 receptor: PAC1R) correlates with increased neonatal mortality similar to the susceptible period for SIDS in humans. Recent human investigations have further implicated PACAP and PAC1R genes as plausible contributors to the pathomechanism of SIDS. This mini-review comprehensively synthesizes all PACAP-related research from the perspective of SIDS and proposes that PACAP deficiency might offer a promising avenue for studying SIDS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%