Animal models of smoke inhalation injury and related acute and chronic lung diseases

Reczyńska, Katarzyna; Tharkar, Priyanka; Kim, Sally Yunsun; Wang, Yiwei; Pamuła, Elżbieta; Chan, Hak-Kim; Chrzanowski, Wojciech

doi:10.1016/j.addr.2017.10.005

Cited by 26 publications

(14 citation statements)

References 170 publications

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“…It is vital to interrogate an organism at multiple levels including molecular, cellular, organ, and whole organism to fully comprehend the intricacies of a disease [159]. There are a number of small animal models that adequately recapitulate individual features of COPD and choosing the most representative model has become an integral factor in the development of novel COPD treatments [160]. Current models used to investigate COPD, which display a range of similar anatomical and physiological responses to COPD-inducing stimuli in humans, include rodents, dogs, guinea pigs, non-human primates, and sheep (as reviewed in [23, [161][162][163] and summarized within Table 1).…”

Section: Animal Modelsmentioning

confidence: 99%

“…Mice offer several advantages over other species, including low housing costs, relatively short breeding time in comparison to higher species, extensive knowledge of the genome [224,225], ease of genetic modifications [160,226], and heterogeneity of reactions to exogenous stimuli amongst different murine strains [177,224,227]. CS is most commonly used to induce COPD in mice [25,176,195,[228][229][230].…”

Section: Micementioning

confidence: 99%

“…Hamsters are the fifth most used laboratory animal (behind mice, rats, rabbits, and guinea pigs [23,160]), and are more commonly used for vaccine production and therapeutic studies [256][257][258]. Hamsters produce significantly more nitric oxide than other rodents following lung injury [259] and have been used in several studies investigating both CS exposure [260][261][262][263] and diesel smoke exposure [264,265].…”

Section: Hamstersmentioning

confidence: 99%

“…The dog is one of few animal models that exhibits a cough reflex, an important physiological symptom of COPD [281]. Respiratory studies using dogs are hampered by increased costs and limited species-specific reagents [160].…”

Section: Dogsmentioning

confidence: 99%

“…Sheep are fairly docile laboratory animals weighing 35-55 kg [160]. Irregular dichotomous branching of the bronchioles combined with similar mucus production DOI: 10.1159/000502489 and epithelial cell distribution in the airways lead to human-like responses following smoke exposure [286][287][288].…”

Section: Sheepmentioning

confidence: 99%

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Animal Models Reflecting Chronic Obstructive Pulmonary Disease and Related Respiratory Disorders: Translating Pre-Clinical Data into Clinical Relevance

Tanner

Single

2019

J Innate Immun

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Chronic obstructive pulmonary disease (COPD) affects the lives of an ever-growing number of people worldwide. The lack of understanding surrounding the pathophysiology of the disease and its progression has led to COPD becoming the third leading cause of death worldwide. COPD is incurable, with current treatments only addressing associated symptoms and sometimes slowing its progression, thus highlighting the need to develop novel treatments. However, this has been limited by the lack of experimental standardization within the respiratory disease research area. A lack of coherent animal models that accurately represent all aspects of COPD clinical presentation makes the translation of promising in vitro data to human clinical trials exceptionally challenging. Here, we review current knowledge within the COPD research field, with a focus on current COPD animal models. Moreover, we include a set of advantages and disadvantages for the selection of pre-clinical models for the identification of novel COPD treatments.

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Section: Animal Modelsmentioning

confidence: 99%

Section: Micementioning

confidence: 99%

Section: Hamstersmentioning

confidence: 99%

Section: Dogsmentioning

confidence: 99%

Section: Sheepmentioning

confidence: 99%

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Animal Models Reflecting Chronic Obstructive Pulmonary Disease and Related Respiratory Disorders: Translating Pre-Clinical Data into Clinical Relevance

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Single

2019

J Innate Immun

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Acute Neurobehavioral and Glial Responses to Explosion Gas Inhalation in Rats

Liu,

Gao,

Wang

et al. 2024

Environmental Toxicology

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Military personnel, firefighters, and fire survivors exhibit a higher prevalence of mental health conditions such as depression and post‐traumatic stress disorder (PTSD) compared to the general population. While numerous studies have examined the neurological impacts of physical trauma and psychological stress, research on acute neurobehavioral effects of gas inhalation from explosions or fires is limited. This study investigates the early‐stage neurobehavioral and neuronal consequences of acute explosion gas inhalation in Sprague–Dawley rats. Rats were exposed to simulated explosive gas and subsequently assessed using behavioral tests and neurobiological analyses. The high‐dose exposure group demonstrated significant depression‐like behaviors, including reduced mobility and exploration. However, neuronal damage was not evident in histological analyses. Immunofluorescence revealed increased density of radial glia and oligodendrocytes in specific brain regions, suggesting hypoxia and axon damage induced by gas inhalation as a potential mechanism for the observed neurobehavioral changes. These findings underscore the acute impact of explosion gas inhalation on mental health, highlighting the habenula and dentate gyrus of hippocampus as the possible target regions. The findings are expected to support early diagnosis and treatment strategies for brain injuries caused by explosion gas, offering insights into early intervention for depression and PTSD in affected populations.

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The role of murine models in the study of the respiratory tract immune response induced by particulate matter

Gómez-Gallego

Tabares-Guevara

Marín-Palma

et al. 2022

Air Qual Atmos Health

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Animal models of smoke inhalation injury and related acute and chronic lung diseases

Cited by 26 publications

References 170 publications

Animal Models Reflecting Chronic Obstructive Pulmonary Disease and Related Respiratory Disorders: Translating Pre-Clinical Data into Clinical Relevance

Animal Models Reflecting Chronic Obstructive Pulmonary Disease and Related Respiratory Disorders: Translating Pre-Clinical Data into Clinical Relevance

Acute Neurobehavioral and Glial Responses to Explosion Gas Inhalation in Rats

The role of murine models in the study of the respiratory tract immune response induced by particulate matter

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