Animal Models of Recently Emerged Bat‐Borne Viruses

Pallister, Jackie; Middleton, Deborah

doi:10.1002/9781118818824.ch12

Cited by 2 publications

(2 citation statements)

References 142 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since most of the animal reservoir hosts do not mimic the pathogenesis in humans of specific viruses, it is very difficult to develop any suitable in vivo model that can be exploited in order to dissect pathogenic events and thereby to achieve the hypothesized outcome [9,156]. Furthermore, while animal reservoirs may become infected with the discussed viruses they do not develop any clinical symptoms [157].…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

Decoding the enigma of antiviral crisis: Does one target molecule regulate all?

et al. 2019

View full text Add to dashboard Cite

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

Decoding the enigma of antiviral crisis: Does one target molecule regulate all?

et al. 2019

View full text Add to dashboard Cite

“… 7 In the case of humanized mice, immunodeficient animals can be injected with human hematopoietic stem cells, resulting in mice with functional human cells, tissues, and organs. 8 , 9 Small animal models designed for pathogenesis studies have also allowed for the initial assessment of candidate human vaccines and therapeutics. 10 Well-developed small animal models tend to replicate the virus of interest, ideally inducing reproducible clinical disease and pathology that closely mimics human illness based on natural routes of exposure.…”

Section: Introductionmentioning

confidence: 99%

Livestock and Risk Group 4 Pathogens: Researching Zoonotic Threats to Public Health and Agriculture in Maximum Containment

Lewis

Pickering

2020

ILAR Journal

View full text Add to dashboard Cite

Maximum-containment laboratories are a unique and essential component of the bioeconomy of the United States. These facilities play a critical role in the national infrastructure, supporting research on a select set of especially dangerous pathogens, as well as novel, emerging diseases. Understanding the ecology, biology, and pathology at the human-animal interface of zoonotic spillover events is fundamental to efficient control and elimination of disease. The use of animals as human surrogate models or as target-host models in research is an integral part of unraveling the interrelated components involved in these dynamic systems. These models can prove vitally important in determining both viral- and host-factors associated with virus transmission, providing invaluable information that can be developed into better risk mitigation strategies. In this article, we focus on the use of livestock in maximum-containment, biosafety level-4 agriculture (BSL-4Ag) research involving zoonotic, risk group 4 pathogens and we provide an overview of historical associated research and contributions. Livestock are most commonly used as target-host models in high-consequence, maximum-containment research and are routinely used to establish data to assist in risk assessments. This article highlights the importance of animal use, insights gained, and how this type of research is essential for protecting animal health, food security, and the agriculture economy, as well as human public health in the face of emerging zoonotic pathogens. The utilization of animal models in high-consequence pathogen research and continued expansion to include available species of agricultural importance is essential to deciphering the ecology of emerging and re-emerging infectious diseases, as well as for emergency response and mitigation preparedness.

show abstract

Animal Models of Recently Emerged Bat‐Borne Viruses

Cited by 2 publications

References 142 publications

Decoding the enigma of antiviral crisis: Does one target molecule regulate all?

Decoding the enigma of antiviral crisis: Does one target molecule regulate all?

Livestock and Risk Group 4 Pathogens: Researching Zoonotic Threats to Public Health and Agriculture in Maximum Containment

Contact Info

Product

Resources

About