Animal models of human nutritional diseases: a short overview

Vasconcelos, Carlos Augusto Carvalho de

doi:10.5581/1516-8484.20120068

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…The most commonly employed models are adult mice and rats (outbred or isogenic) fed with reduced amount of proteins, vitamins or micronutrients [47]. The long history of animal experimentation describes the use of a series of methods that not only include the use of whole animals but isolated organs, isolated tissues, tissue cultures, isolated cells, subcellular components, modeling and structure-activity relationships [48]. As immunodeficiency associated with prepubescent malnutrition underlies a very high burden of infection-related morbidity, acute weanling mice have also been explored to investigate the effects of malnutrition [49].…”

Section: Nutrition and The Immune Systemmentioning

confidence: 99%

The immune-nutrition interplay in aging – facts and controversies

Alam

Almajwal

Alam

et al. 2019

NHA

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Nutrition influences immunity in multiple ways, with different nutrients affecting many immune parameters. Aging also affects immunity, making the outcome of the interplay between nutrition, age and immunity complex. Moreover, a particular nutrient may alter the whole immune constellation as deficiency of one nutrient may affect the proper metabolism of another nutrient and elicit a chain reaction of secondary malnutrition. In this article, we review these interactions and the possible mechanisms mediating such relationships.

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Section: Nutrition and The Immune Systemmentioning

confidence: 99%

The immune-nutrition interplay in aging – facts and controversies

Alam

Almajwal

Alam

et al. 2019

NHA

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“…Experimental models involving diets and peripheral nerves are indispensable to assist in current research, since peripheral neuropathies, particularly diabetic neuropathy is a devastating common comorbidity in diabetic patients. [4,5,6] Nowadays, Diabetic Neuropathy (DN) is considered the most common cause of peripheral neuropathy in clinical practice. It can affect sensitive, motor or autonomic nerve fibers, with symmetric, asymmetric, acute or chronic presentations.…”

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confidence: 99%

Ultrastructural aspects of cranial and peripheric nerves of cronically diabetic and malnourished rats: a short biochemical panorama

Saraiva¹,

Pontes²,

Pinho³

et al. 2015

Int Arch Med

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Diabetes Mellitus is one of the most common causes of neuropathies, which can be caused by molecular imbalances that impair metabolic pathways. Studies in rats showed the importance of sirtuins (SIRT), deacetylases that use NAD + as a cofactor, which have a widespread function in metabolism, and their relation when food deprived or calorie restricted. Additionally, diabetic neuropathy presents different structural biomarkers that cause morphological alterations in fibers that can be partially treated. SIRT1 is the principal sirtuin, which acts on hypothalamus, liver, kidney, among other organs, up regulating or down regulating the expression of some genes or enzymes crucial in the process of glucose absorption.

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Animal models of human nutritional diseases: a short overview

Cited by 2 publications

References 3 publications

The immune-nutrition interplay in aging – facts and controversies

The immune-nutrition interplay in aging – facts and controversies

Ultrastructural aspects of cranial and peripheric nerves of cronically diabetic and malnourished rats: a short biochemical panorama

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