Animal Models of Hearing Loss after Cochlear Implantation and Electrical Stimulation

Reiss, Lina A. J.; Kirk, Jonathon; Claussen, Alexander D.; Fallon, James B

doi:10.1016/j.heares.2022.108624

Cited by 8 publications

(8 citation statements)

References 96 publications

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“…There are, however, several considerations in the applicability of different animal models for human CI research in terms of both their anatomy and physiology. The cochlea varies in size, shape, and complexity amongst different species, with differences in the length, width, and number of turns [73,78,123]. Although the overall scalar structure is largely conserved in mammals, the overall shape and size do not scale linearly with overall body size, indicating that factors other than body size determine the cochlea's structure [78].…”

Section: Animal Modelsmentioning

confidence: 99%

“…Several different animal models have been used for studies that are interested in structure-related parameters and CI implantation. Rodent models such as mice, rats, gerbils, guinea pigs, ferrets, and chinchillas have been widely used in CI research due to their availability, potential for instrumentation, and established gene-editing tools in the case of mice and rats; as reviewed by Reiss [123]. Guinea pigs, in particular, have been extensively used due to their wide availability, their inner ears being easy to access, and their cochleae being more comparable to the human cochlea in several physiological aspects [4,51,58,86,147].…”

Section: Animal Modelsmentioning

confidence: 99%

“…Moreover, the lack of myelin in the soma regions of human type I primary auditory neurons causes a delay in spike conduction compared to cat neurons [119], which can impact the transmission of temporal fine structure of auditory signals in the human cochlea. Larger animal models include sheep [128] and miniature pigs [156] as well as marmoset [73] and rhesus macaque monkeys [97,123]. These are closer to the size of human cochleae, with the marmoset cochlear shape being most similar when scaled up by a factor of 2.5 [73], and allow the partial implantation of clinical electrodes although these model are much less available than small rodents and do not well replicate many of the specific features of human cochleae which are not even featured in other primates [151].…”

Section: Animal Modelsmentioning

confidence: 99%

“…These are closer to the size of human cochleae, with the marmoset cochlear shape being most similar when scaled up by a factor of 2.5 [73], and allow the partial implantation of clinical electrodes although these model are much less available than small rodents and do not well replicate many of the specific features of human cochleae which are not even featured in other primates [151]. For comparison, the ratio of the volume of the human cochlea to different animal cochleae is as follows: mouse 80-100:1, rat 20-25:1, gerbil 5-6:1, cat 2-3:1, macaque 2-3:1, and sheep ~ 1.7:1 [123].…”

Section: Animal Modelsmentioning

confidence: 99%

See 3 more Smart Citations

Models of Cochlea Used in Cochlear Implant Research: A Review

et al. 2023

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As the first clinically translated machine-neural interface, cochlear implants (CI) have demonstrated much success in providing hearing to those with severe to profound hearing loss. Despite their clinical effectiveness, key drawbacks such as hearing damage, partly from insertion forces that arise during implantation, and current spread, which limits focussing ability, prevent wider CI eligibility. In this review, we provide an overview of the anatomical and physical properties of the cochlea as a resource to aid the development of accurate models to improve future CI treatments. We highlight the advancements in the development of various physical, animal, tissue engineering, and computational models of the cochlea and the need for such models, challenges in their use, and a perspective on their future directions.

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Section: Animal Modelsmentioning

confidence: 99%

Section: Animal Modelsmentioning

confidence: 99%

Section: Animal Modelsmentioning

confidence: 99%

Section: Animal Modelsmentioning

confidence: 99%

See 2 more Smart Citations

Models of Cochlea Used in Cochlear Implant Research: A Review

et al. 2023

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“…For those severely hearing impaired, implantable auditory devices, such as hybrid cochlear implants (which combine hearing aid and cochlear implant technology), represent a limited option ( 3, 4 ). However, these devices require surgical intervention, and 30%–55% of hearing-impaired patients encounter over 30 dB HL of residual hearing loss due to the complications of post-surgical implantation ( 5 ); implantable auditory devices pose challenges, especially in preserving residual hearing for hybrid implants.…”

Section: Introductionmentioning

confidence: 99%

Non-invasive optical synthetization of hearing sensation in non-genetically modified animal

Tamai

Uenaka

Okamoto

et al. 2023

Preprint

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The application of infrared laser stimulation to brain-machine interfaces, such as cochlear implants, has been discussed over the last decade because the infrared laser can activate spatially selected neural populations without delivering exogenous agents to tissues. Here, this study demonstrated for the first that the laser irradiation of the peripheral sensory organ, the cochlea, can induce an unequivocal behavioral auditory response. We proved that the animals, Mongolian gerbils (Meriones unguiculatus), can be classically conditioned with a laser stimulus in a similar way to an auditory stimulus. Additionally, the auditory masking significantly inhibited the laser-conditioned response, and the auditory-conditioned animals exhibited stimulus generalization to laser stimulation. In a subsequent experiment, simultaneous presentation of auditory and laser stimulation successfully elicited nonlinear amplification in both the auditory cortical and behavioral response. These results suggest that the infrared laser irradiation to the cochlea can evoke and possibly enhance auditory perception and has real potential to be implemented in an auditory prosthesis.

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