Animal models of fibromyalgia

DeSantana, Josimari Melo; Cruz, Kamilla M.L.; Sluka, Kathleen A.

doi:10.1186/ar4402

Cited by 95 publications

(68 citation statements)

References 79 publications

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“…In particular, animal models that reflect the target pathophysiology responsible for dysfunctional pain are required. Currently, hypothesis-based animal models of dysfunctional pain include stress-induced visceral pain models (e.g., maternal separation, neonatal irritation, and high-anxiety WKY strain models) [21] and several putative fibromyalgia models (e.g., acid saline injections, biogenic amine depletion, cold stress and fatigue-enhanced muscle pain models) [22]. Given that dysfunctional pain in patients is associated with pain amplification in the central nervous system [10,12,13], manifestation of this phenomenon is essential in animal models.…”

Section: Expert Opinionmentioning

confidence: 99%

Challenges in drug discovery for overcoming ‘dysfunctional pain’: an emerging category of chronic pain

Nagakura

2015

Expert Opinion on Drug Discovery

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Section: Expert Opinionmentioning

confidence: 99%

Challenges in drug discovery for overcoming ‘dysfunctional pain’: an emerging category of chronic pain

Nagakura

2015

Expert Opinion on Drug Discovery

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“…More recently, rodent models that mimic the signs and symptoms of FM, including long lasting hyperalgesia without overt peripheral tissue damage [80] and also CFS, including mechanical allodynia and hyperalgesia without signs of inflammation and injury but activated microglia [81], have been developed. While a variety of methods such as repeated muscle insults with acid injections, depletion of biogenic amines, and stress were used for the first, a multiple continuous stress of housed in a cage with a low level of water (1.5 cm in depth) was used for the second [80,81].…”

Section: Mt Impact On the Nervous System And On Pain Reliefmentioning

confidence: 99%

“…For this reason it results necessary that the evaluation of a treatment includes animal disease models that faithfully replicate the disease. Despite the lack of validated biomarkers for FM and CFS/ME a few animal models have been developed [80,81] which could be used for comparison.…”

Section: Future Directionsmentioning

confidence: 99%

Unraveling molecular determinants of manual therapy: an approach to integrative therapeutics for the treatment of fibromyalgia and CFS/ME

Espejo¹,

García-Escudero²,

Oltra³

2018

Preprint

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Abstract:Application of protocols without parameter standardization and rigorous controls has led manual therapy (MT) and other physiotherapy approaches to controversial outcomes. Thus, there is an urgency to carefully define standard protocols that elevate physiotherapy treatments to rigorous scientific demands. One way this can be achieved is by studying gene expression and additional physiological changes that associate to particular, parameter-controlled, treatments in animal models and translating this knowledge to properly design objective, quantitatively-monitored clinical trials. Here, we propose a Molecular Physiotherapy Approach (MPTA), requiring multidisciplinary teams, to uncover the scientific reasons behind the numerous reports of MT that historically attribute benefits to these treatments. The review focuses in the identification of MT-induced physiological and molecular responses that could be used for the treatment of fibromyalgia (FM) and CFS/ME. The systemic effect associated to mechanical-load responses is considered of particular relevance as it suggests that defined, low-pain areas could be selected for treatments with overall benefits, an aspect that might result essential to treat FM. Additionally, MT can provide muscle conditioning to sedentary patients without demanding strenuous physical effort, detrimental for CFS/ME patients, placing MT as a real option for integrative medicine programs to treat FM and CFS/ME.

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“…There are also several unique models induced by reserpine treatment (Nagakura et al, 2009) and intermittent sound stress (Khasar et al, 2009). These animal models share some pathophysiological or behavioral features with fibromyalgia patients (DeSantana et al, 2013). In addition, we have reported another fibromyalgia-like pain model caused by intermittent cold stress (ICS) (Nishiyori and Ueda, 2008).…”

Section: Introductionmentioning

confidence: 96%

Donepezil Reverses Intermittent Stress-Induced Generalized Chronic Pain Syndrome in Mice

Mukae

Uchida

Ueda

2015

J Pharmacol Exp Ther

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Treatment of fibromyalgia is an unmet medical need. To develop novel therapies for the treatment of fibromyalgia, we explored pain therapeutic actions of existing pharmaceuticals, which inhibit the somatic symptoms frequently observed in fibromyalgia patients. This study first examined the therapeutic actions of pilocarpine, which inhibits dry-eye and dry-mouth symptoms, using an experimental fibromyalgia-like chronic pain model produced by intermittent cold stress (ICS) in mice. A single intraperitoneal and intracerebroventricular, but not intrathecal, pilocarpine administration attenuated ICS-induced thermal hyperalgesia and mechanical allodynia, and this action was abolished by muscarinic antagonist pirenzepine (i.c.v.). Treatment with 1-10 mg/kg donepezil (i.p.), which can easily penetrate into the brain, also showed similar therapeutic effects. Importantly, we found that both pilocarpine and donepezil produced antihyperalgesic effects via supraspinal action. Furthermore, repeated donepezil treatments completely cured the ICS-induced hyperalgesia and allodynia even after the cessation of drug treatments. Acute and chronic treatments of these cholinomimetics had no effects on the nociceptive threshold in control animals. By contrast, the lack of morphine (i.c.v.) analgesia initially observed in the ICS model remained in ICS model mice treated with long-term donepezil. Collectively, these findings suggest that stimulation of the muscarinic cholinergic system effectively inhibits some mechanisms underlying chronic pain in the ICS model, but does not inhibit the lack of descending pain-inhibitory mechanisms, which are driven by central morphine.

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Animal models of fibromyalgia

Cited by 95 publications

References 79 publications

Challenges in drug discovery for overcoming ‘dysfunctional pain’: an emerging category of chronic pain

Challenges in drug discovery for overcoming ‘dysfunctional pain’: an emerging category of chronic pain

Unraveling molecular determinants of manual therapy: an approach to integrative therapeutics for the treatment of fibromyalgia and CFS/ME

Donepezil Reverses Intermittent Stress-Induced Generalized Chronic Pain Syndrome in Mice

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