Animal models of disuse-induced bone loss: study protocol for a systematic review

Brent, Mikkel Bo; Brüel, Annemarie; Thomsen, Jesper Skovhus

doi:10.1186/s13643-020-01441-3

Cited by 8 publications

(3 citation statements)

References 32 publications

(36 reference statements)

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“…Виконані на сьогодні експериментальні дослідження на тваринах сприяють розширенню наших уявлень щодо морфологічних змін кісткової тканини і з'ясування патогенезу її втрати в умовах відсутності навантаження. Розроблено різні моделі, що імітують порушення механічного впливу на скелет, зокрема фіксація кінцівок, гіпокінезія з використанням вузьких кліток, різні моделі розвантаження задніх кінцівок, хімічна денервація шляхом ін'єкцій ботулотоксину тощо [10,11].…”

Section: патофізіологія та механізми розвитку постіммобілізаційного о...unclassified

Disuse (post-mobilization) osteoporosis: literature review and clinical case series

Grygorieva

Dedukh

Parubets

et al. 2022

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Background. Disuse (рost-immobilization) osteoporosis is defined as secondary loss of bone mass in case of the absence or insufficient mechanical load on the skeleton. This disease can be associated with various risk factors, including long-time bed rest. The purpose of the research was to analyze modern literary data on the mechanisms of development, principles of diagnosis and treatment of disuse osteoporosis and to present own clinical data of disuse osteoporosis in the patients with multiple injuries of the skeleton in the conditions of war in Ukraine. Materials and methods. The review was based on the analysis of literature sources from the PubMed, WOS, Scopus, Google, Google Scholar, Cochrane Library databases for the years 2007–2022. The search was conducted using keywords: disuse osteoporosis, immobilization, bed rest, bone mineral density (BMD), bone remodeling, regeneration. Results. The data on the theory of the mechanostat are considered as links in the appearance of disuse osteoporosis. In conditions of immobilization, bone remodeling processes are slowing down. Histomorphometric studies confirm a decrease in trabecular bone density, thickness of the cortical layer, and an increase in its porosity. A change in bone architecture with a biphasic course is observed. Disruption of the synchronicity of remodeling processes with a decrease in the rate of osteoblastogenesis and an increase in osteoclastogenesis was noted, and the role of osteocytes as mechanosensors was emphasized. Disuse osteoporosis leads to a violation of biochemical marker of bone metabolism. Early laboratory manifestations of bed rest were recorded in the form of a violation of calcium level, an increase in bone resorption markers, while bone formation markers did not change significantly. Bone loss in disuse osteoporosis is manifested by a decrease in BMD indices. The greatest decrease was recorded in the lower extremities’ bones and the vertebrae of the lumbar spine. Modern methods of treatment of disuse osteoporosis involve the use of antiresorptive and osteoanabolic agents but clinical data are limited, which requires multicenter randomized studies. The article presents 3 clinical examples of disuse osteoporosis after gunshot fractures of the lower extremities’ bones.

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Section: патофізіологія та механізми розвитку постіммобілізаційного о...unclassified

Disuse (post-mobilization) osteoporosis: literature review and clinical case series

Grygorieva

Dedukh

Parubets

et al. 2022

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“…It was reported as well that the patient was in a development phase, with several epiphyseal plaques still visible and cortical with reduced thickness.There are some less radiopaque areas observed in the patient's long bones possibly caused by an osteoporosis due to disuse. It is correlated by a reduced mechanic tension above bones that leads to a decreased stimulus of bone formation and a disproportional increase of bone resorption, turning it more fragile(Brent et al, 2020). The femoral heads were poorly defined in the evaluated position, and left metatarsals had a slight curvature.…”

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confidence: 99%

Bilateral patellar agenesis in dog: A case report

Lage

Pozavski

Lamounier

et al. 2022

Anat Histol Embryol

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A bilateral patellar agenesis is an extremely rare congenital condition in which the patient does not develop both patellas and can present secondary alterations as bone, muscle and postural changes. There are some hypotheses that it has a genetic background presenting dominant characteristic. It is not yet standardized a gold treatment for this affection, but according to rare reports, clinical and surgical treatments are possible. This is a case report based on imagining exams of a mix breed male puppy that was born with bilateral patellar agenesis, an affection not yet reported in canine species.

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“…Osteoporosis is a multifactorial metabolic disorder whose pathogenesis involves a range of endogenous and exogenous factors affecting the bone tissue, while the various types of osteoporosis modeling involving animal enable exploring the specific features of disorders affecting various bones, duration of pathological process and their manifestations in the compact and trabecular bone, as well as detailing the body changes. Using various experimental osteoporosis models, one may describe the bone remodeling based on histological, morphometric and biochemical studies, as well as use biomechanical methods to test the bone strength and quality under various triggers of osteoporosis and to determine some pathogenic pathways of this condition [1,[4][5][6][7]. Using experimental models to explore the induced osteoporosis one © 2021.…”

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confidence: 99%

Experimental Modeling of Osteoporosis in Animals

Dedukh

Yakovenchuk

Nikolchenko

2021

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Experimental studies on animals under conditions of osteopenia and osteoporosis modeling significantly expand the view of the mechanisms of primary and secondary osteoporosis development, help determining the effect of various factors affecting the bone tissue, evaluate the effect of medications, new biomaterials, etc. Osteoporosis is a multifactorial disease; its clinical manifestations depend on a complex interplay of environmental, lifestyle and genetic factors. The review of the literature analyzes the data on the use of animals to assess the features of osteoporosis course when modeling this pathology by surgical and non-surgical methods. The article features the models of osteoporosis which are reproduced on rats and mice being the most accessible objects and the most frequently used by experimenters. The details of modeling the course of such types of osteoporosis as postmenopausal, senile, glucocorticoid-induced, testosterone deficiency (orchiectomy)-induced, immobilization, hypothermia, radiation-induced, etc. are explored. A specific aspect of recent advances in modeling osteoporosis is the creation of transgenic and knockout mice, whose models may be used to detect components of genetic lesions and will certainly contribute to the development of new methods of prevention and therapy of this severe pathology. The similarity and difference of experimental models of osteoporosis describing the pathophysiological changes in humans due to osteoporosis are noted. Emphasis is placed on bioethical norms of working with experimental animals.

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Animal models of disuse-induced bone loss: study protocol for a systematic review

Cited by 8 publications

References 32 publications

Disuse (post-mobilization) osteoporosis: literature review and clinical case series

Disuse (post-mobilization) osteoporosis: literature review and clinical case series

Bilateral patellar agenesis in dog: A case report

Experimental Modeling of Osteoporosis in Animals

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