Animal Models of Diabetes

Malaisse, Willy; Sener, Abdullah

doi:10.1007/978-1-59745-285-4_67

Cited by 2 publications

(1 citation statement)

References 52 publications

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“…Female NOD mice are used extensively as a model for human autoimmune T1D [12][13][14][15][16][17]. Numerous studies have shown that under specific-pathogen-free conditions typically 70-90% of female NOD mice develop diabetes spontaneously by 45 weeks of age [9,11].…”

Section: Discussionmentioning

confidence: 99%

Untitled

2018

CRDOJ

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Metabolism of the amino acid L-arginine is implicated in many physiological and pathophysiological processes including autoimmune conditions such as type 1 diabetes (T1D). Alternate arginine metabolism through the citrulline-nitric oxide (NO) or the ornithine pathways can lead to proinflammatory or immune regulatory effects, respectively. In this report, we blocked the arginine-ornithine metabolic pathway by inhibiting the enzyme arginase-1 with Nω-hydroxy-nor-arginine (nor-NOHA) to make arginine more available to the alternate citrulline pathway for augmented NO production and increased incidence of autoimmune T1D in female non-obese diabetic (NOD) mice. Unexpectedly, mice receiving nor-NOHA did not develop diabetes although increased NO production is proinflammatory and expected to increase diabetes incidence. These results warrant further studies of the mechanism of action of nor-NOHA, and highlight its potential as a therapeutic agent for the treatment or prevention of T1D.

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Section: Discussionmentioning

confidence: 99%

Untitled

2018

CRDOJ

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How to create an experimental diabetes mellitus model?

Köprülü¹

2023

PHAR

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Diabetes is a metabolic disorder characterized by chronic hyperglycemia. Early treatment is very important in terms of preventing diabetes-related late complications with high treatment costs and increasing the patient’s quality of life. In addition to investigating the pathophysiology of the disease studied, animal experiments pave the way for new approaches in treatments. Although there are many methods that can be used when creating a diabetes model, induction of diabetes with alloxan and streptozotocin are the most preferred ones. The aim of this article is to review the available information on diabetes-related methods, common problems and solutions, with known mechanisms of action, dose and time-determined methods.

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Animal Models of Diabetes

Cited by 2 publications

References 52 publications

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How to create an experimental diabetes mellitus model?

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Animal Models of Diabetes

Cited by 2 publications

References 52 publications

Untitled

Untitled

﻿How to create an experimental diabetes mellitus model?

Contact Info

Product

Resources

About

How to create an experimental diabetes mellitus model?