Animal Models in Toxicologic Research: Pig

Helke, Kristi L.; Nelson, Keith; Sargeant, Aaron M.

doi:10.1016/b978-0-12-821044-4.00001-7

Cited by 1 publication

(3 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dippity Pig Syndrome (DPS) is a common clinical term for clinical signs that may be diagnosed as acute dermatitis or erythema multiforme [1][2][3][4][5][6][7][8][9][10]. The affected animals show acute red, exudating lesions that develop characteristically across the spine.…”

Section: Introductionmentioning

confidence: 99%

“…The syndrome is self-limiting (but should always be pain treated), and the lesions will heal in a relatively short period of time (a few days to 2 weeks) with no scarring. In Go ¨ttingen minipigs, the syndrome is recognized in all age groups, whereas in potbelly pigs it has been described as more commonly affecting pigs less than one year old [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…Although pig and veterinary associations informed in detail about DPS [7][8][9][10], there are only very few scientific publications investigating cases of DPS [1][2][3][4][5][6]17] and these publications usually only include a short description of the disease. The literature describing erythema multiforme in commercial breeding pig herds is also rare [15,16].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

First virological and pathological study of Göttingen Minipigs with Dippity Pig Syndrome (DPS)

Jhelum

Grand²,

Jacobsen³

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Dippity Pig Syndrome (DPS) is a well-known but rare complex of clinical signs affecting minipigs, which has not been thoroughly investigated yet. Clinically affected animals show acute appearance of red, exudating lesions across the spine. The lesions are painful, evidenced by arching of the back (dipping), and the onset of clinical signs is generally sudden. In order to understand the pathogenesis, histological and virological investigations were performed in affected and unaffected Göttingen Minipigs (GöMPs). The following DNA viruses were screened for using PCR-based methods: Porcine cytomegalovirus (PCMV), which is a porcine roseolovirus (PCMV/PRV), porcine lymphotropic herpesviruses (PLHV-1, PLHV-2, PLHV-3), porcine circoviruses (PCV1, PCV2, PCV3, PCV4), porcine parvovirus 1 (PPV1), and Torque Teno sus viruses (TTSuV1, TTSuV2). Screening was also performed for integrated porcine endogenous retroviruses (PERV-A, PERV-B, PERV-C) and recombinant PERV-A/C and their expression as well as for the RNA viruses hepatitis E virus (HEV) and SARS-CoV-2. Eight clinically affected and one unaffected GöMPs were analyzed. Additional unaffected minipigs had been analyzed in the past. The analyzed GöMPs contained PERV-A and PERV-B integrated in the genome, which are present in all pigs and PERV-C, which is present in most, but not all pigs. In one affected GöMPs recombinant PERV-A/C was detected in blood. In this animal a very high expression of PERV mRNA was observed. PCMV/PRV was found in three affected animals, PCV1 was found in three animals with DPS and in the unaffected minipig, and PCV3 was detected in two animals with DPS and in the unaffected minipig. Most importantly, in one animal only PLHV-3 was detected. It was found in the affected and unaffected skin, and in other organs. Unfortunately, PLHV-3 could not be studied in all other affected minipigs. None of the other viruses were detected and using electron microscopy, no virus particles were found in the affected skin. No porcine virus RNA with exception of PERV and astrovirus RNA were detected in the affected skin by next generation sequencing. This data identified some virus infections in GöMPs with DPS and assign a special role to PLHV-3. Since PCMV/PRV, PCV1, PCV3 and PLHV-3 were also found in unaffected animals, a multifactorial cause of DPS is suggested. However, elimination of the viruses from GöMPs may prevent DPS.

show abstract

Section: Introductionmentioning

confidence: 99%