Animal Models in Mycology

Kamei, Katsuhiko; Miyaji, Makoto

doi:10.1159/000060389

Cited by 1 publication

(2 citation statements)

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“…A form of zygomycosis in humans is frequently seen with ketoacidosis. 22 All the cattle in this study originated from feedlots, production systems in which ketoacidosis is a common problem. However, most cattle slaughtered in the USA originate in feedlots, and zygomycotic lymphadenitis does not seem to be a problem in other areas of the country.…”

Section: Discussionmentioning

confidence: 99%

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Zygomycotic Lymphadenitis in Slaughtered Feedlot Cattle

et al. 2010

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During the 12 months of 2006, zygomycotic lymphadenitis was diagnosed in 194 of 198 feedlot steers (0.04% of cattle slaughtered during that period) in a California slaughterhouse as part of bovine tuberculosis surveillance. Mesenteric lymph nodes were involved in 190 cases. Affected lymph nodes were enlarged (2 to 42 cm in greatest dimension), firm, and mottled gray-white to yellow with multiple granular or caseocalcareous foci. Histologically, nodal architecture was effaced by necrosis, granulomatous inflammation, and fibrosis. In approximately 20% of the cases, granulomas were mainly restricted to subcapsular sinuses and afferent lymphatic vessels, causing granulomatous lymphangitis. Nonseptate, irregularly branching hyphae with nonparallel walls and bulbous enlargements were common in necrotic areas and within the cytoplasm of multinucleated giant cells. Fungal cultures were performed on 124 affected lymph nodes using 7 media, but no zygomycetes were cultured. Fungal DNA was amplified from 20 lymph nodes. Amplicons from 16 nodes had nearly 100% homology with sequences for Rhizomucor pusillus; 4 amplicons had (> 98%) homology with Absidia corymbifera sequences. Zygomycosis should be considered in the differential diagnosis for granulomatous lymphadenitis in feedlot steers.

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Section: Discussionmentioning

confidence: 99%

“…2,18,29 The frequency of reports of zygomycosis in humans and animals has increased recently. 22 Several other terms have been applied to infections with these fungi. For example, the term mucormycosis has been used to designate infections caused by various species within the order Mucorales, 33 in the class Zygomycetes.…”

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confidence: 99%