Animal Models for the Study of Food Allergies

Kazemi, Sima; Danisman, Ece; Epstein, Michelle M

doi:10.1002/cpz1.685

Cited by 8 publications

(2 citation statements)

References 187 publications

(344 reference statements)

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“…Mouse models of food allergy have been developed to understand further and elucidate underlying disease mechanisms ( 44 ). To date, it is not clear whether any of the models fully replicate human disease or whether they are able to predict protein allergenicity or adjuvanticity despite being used to assess the allergenicity and adjuvanticity risks of GMOs ( 45 , 46 ).…”

Section: Allergenicity Prediction In Risk Assessment—current State An...mentioning

confidence: 99%

Research gaps and future needs for allergen prediction in food safety

Fernandez,

Danisman,

Taheri Boroujerdi

et al. 2024

Front. Allergy

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The allergenicity and protein risk assessments in food safety are facing new challenges. Demands for healthier and more sustainable food systems have led to significant advances in biotechnology, the development of more complex foods, and the search for alternative protein sources. All this has increased the pressure on the safety assessment prediction approaches anchored into requirements defined in the late 90's. In 2022, the EFSA's Panel on Genetically Modified Organisms published a scientific opinion focusing on the developments needed for allergenicity and protein safety assessments of new products derived from biotechnology. Here, we further elaborate on the main elements described in this scientific opinion and prioritize those development needs requiring critical attention. The starting point of any new recommendation would require a focus on clinical relevance and the development of a fit-for-purpose database targeted for specific risk assessment goals. Furthermore, it is imperative to review and clarify the main purpose of the allergenicity risk assessment. An internationally agreed consensus on the overall purpose of allergenicity risk assessment will accelerate the development of fit-for-purpose methodologies, where the role of exposure should be better clarified. Considering the experience gained over the last 25 years and recent scientific developments in the fields of biotechnology, allergy, and risk assessment, it is time to revise and improve the allergenicity safety assessment to ensure the reliability of allergenicity assessments for food of the future.

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Section: Allergenicity Prediction In Risk Assessment—current State An...mentioning

confidence: 99%

Research gaps and future needs for allergen prediction in food safety

Fernandez,

Danisman,

Taheri Boroujerdi

et al. 2024

Front. Allergy

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“…( Wal, 2015 ). Till date, despite efforts toward developing animal models for accurate prediction of sensitivity to allergy, none has proven to be predictive ( Ladics and Selgrade, 2009 ; Goodman, 2015 ; Kazemi et al, 2023 ). Consequent on this fact, the National Academies of Sciences, Engineering, and Medicine (2016) , suggested the use of pre-commercialization tests to make rough predictions on relationships between consumption of GM-crops and the prevalence of some human diseases.…”

Section: Origin Of Anti-gmo Campaign In the Worldmentioning

confidence: 99%

Genetic engineering and genome editing technologies as catalyst for Africa’s food security: the case of plant biotechnology in Nigeria

Adegbaju,

Ajose,

Adegbaju

et al. 2024

Front. Genome Ed.

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Many African countries are unable to meet the food demands of their growing population and the situation is worsened by climate change and disease outbreaks. This issue of food insecurity may lead to a crisis of epic proportion if effective measures are not in place to make more food available. Thus, deploying biotechnology towards the improvement of existing crop varieties for tolerance or resistance to both biotic and abiotic stresses is crucial to increasing crop production. In order to optimize crop production, several African countries have implemented strategies to make the most of this innovative technology. For example, Nigerian government has implemented the National Biotechnology Policy to facilitate capacity building, research, bioresource development and commercialization of biotechnology products for over two decades. Several government ministries, research centers, universities, and agencies have worked together to implement the policy, resulting in the release of some genetically modified crops to farmers for cultivation and Commercialization, which is a significant accomplishment. However, the transgenic crops were only brought to Nigeria for confined field trials; the manufacturing of the transgenic crops took place outside the country. This may have contributed to the suspicion of pressure groups and embolden proponents of biotechnology as an alien technology. Likewise, this may also be the underlying issue preventing the adoption of biotechnology products in other African countries. It is therefore necessary that African universities develop capacity in various aspects of biotechnology, to continuously train indigenous scientists who can generate innovative ideas tailored towards solving problems that are peculiar to respective country. Therefore, this study intends to establish the role of genetic engineering and genome editing towards the achievement of food security in Africa while using Nigeria as a case study. In our opinion, biotechnology approaches will not only complement conventional breeding methods in the pursuit of crop improvements, but it remains a viable and sustainable means of tackling specific issues hindering optimal crop production. Furthermore, we suggest that financial institutions should offer low-interest loans to new businesses. In order to promote the growth of biotechnology products, especially through the creation of jobs and revenues through molecular farming.

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Protein Allergy and Genetically Engineered Crops

Ladics,

Silvanovich

2024

Reference Module in Biomedical Sciences

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Animal Models for the Study of Food Allergies

Cited by 8 publications

References 187 publications

Research gaps and future needs for allergen prediction in food safety

Research gaps and future needs for allergen prediction in food safety

Genetic engineering and genome editing technologies as catalyst for Africa’s food security: the case of plant biotechnology in Nigeria

Protein Allergy and Genetically Engineered Crops

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