Animal Models for Investigating the Allergic and Inflammatory Properties of Platelets

Coyle, Anthony J.; Vargaftig, B.B.

doi:10.1016/b978-012390120-0/50004-6

Cited by 5 publications

(2 citation statements)

References 53 publications

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“…Furthermore, PAF signaling synergistically augments platelet activation triggered by ADP or thrombin in whole human blood [123]. PAFR signaling and activities of PAF in sepsis, dengue, and anaphylaxis—systemic inflammatory responses in which platelets are targets and/or have key roles [91, 92, 124, 125]—were recently reviewed [126]. …”

Section: Diverse Platelet Signaling Receptors That Are Critical In Hementioning

confidence: 99%

Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum

et al. 2011

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Platelets are chief effector cells in hemostasis. In addition, however, their specializations include activities and intercellular interactions that make them key effectors in inflammation and in the continuum of innate and adaptive immunity. This review focuses on the immune features of human platelets and platelets from experimental animals and on interactions between inflammatory, immune, and hemostatic activities of these anucleate but complex and versatile cells. The experimental findings and evidence for physiologic immune functions include previously unrecognized biologic characteristics of platelets and are paralleled by new evidence for unique roles of platelets in inflammatory, immune, and thrombotic diseases.

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Section: Diverse Platelet Signaling Receptors That Are Critical In Hementioning

confidence: 99%

Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum

et al. 2011

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“…Platelets serve roles that recapitulate and complement cell-mediated immune effector cells. In vitro and in experimental animal models, platelets intensify at sites enriched in microbial stimuli such as N -formyl-methionyl-leucyl-phenylalanine ( N - f -met-leu-phe) [ 29 ] or complement proteins C3a and C5a [ 1 , 7 , 25 , 30 ]. Experiments by Czapigaa et al .…”

Section: Platelets: the Other White Cellsmentioning

confidence: 99%

Platelets in defense against bacterial pathogens

Yeaman

2009

Cell. Mol. Life Sci.

256

234

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Platelets interact with bacterial pathogens through a wide array of cellular and molecular mechanisms. The consequences of this interaction may significantly influence the balance between infection and immunity. On the one hand, recent data indicate that certain bacteria may be capable of exploiting these interactions to gain a virulence advantage. Indeed, certain bacterial pathogens appear to have evolved specific ways in which to subvert activated platelets. Hence, it is conceivable that some bacterial pathogens exploit platelet responses. On the other hand, platelets are now known to possess unambiguous structures and functions of host defense effector cells. Recent discoveries emphasize critical features enabling such functions, including expression of toll-like receptors that detect hallmark signals of bacterial infection, an array of microbicidal peptides, as well as other host defense molecules and functions. These concepts are consistent with increased risk and severity of bacterial infection as correlates of clinical abnormalities in platelet quantity and quality. In these respects, the molecular and cellular roles of platelets in host defense against bacterial pathogens are explored with attention on advances in platelet immunobiology.

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Antimicrobial Host Defense

Yeaman

Bayer

2013

Platelets

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Animal Models for Investigating the Allergic and Inflammatory Properties of Platelets

Cited by 5 publications

References 53 publications

Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum

Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum

Platelets in defense against bacterial pathogens

Antimicrobial Host Defense

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