Animal Models for Acquired Bone Marrow Failure Syndromes

Chen, Jichun

doi:10.3121/cmr.3.2.102

Cited by 52 publications

(42 citation statements)

References 45 publications

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“…Equivalent conditions to the aging and failing heart are found HSC disorders, such as aplastic anemia and myelodysplastic syndromes. 97,98 These pathological conditions cause bone marrow failure, which manifests itself with a drastic decline in HSCs and in the bone marrow's ability to produce mature blood cells. This is mimicked in the aged and decompensated heart in which the balance between cell loss and cell formation is altered in favor of the former, indicating CSC failure.…”

Section: Discussionmentioning

confidence: 99%

Life and Death of Cardiac Stem Cells

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Life and Death of Cardiac Stem Cells

et al. 2006

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“…The use of steroids for the treatment of ARDS has also been discussed. The fact that the present patient developed a high fever followed by abrupt neutropenia and thrombocytopenia suggests the production of higher levels of inflammatory cytokines as indicated (20). Just after the introduction of steroid pulse therapy, the high fever and cytopenia resolved.…”

Section: Discussionmentioning

confidence: 77%

Pandemic (H1N1) 2009-Associated ARDS Rescued by Neuraminidase Inhibitors with Emergency Use of Extracorporeal Membrane Oxygenation

et al. 2010

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A 36-year-old man with underlying systemic lupus erythematosus complicated by autoimmune hemolytic anemia underwent immunosuppressive treatment. After showing a low-grade fever for two days, his fever spiked. He was confirmed to have pandemic (H1N1) 2009 by real-time reverse transcription polymerase chain reaction (PCR). His condition deteriorated to acute respiratory distress syndrome (ARDS), and mechanical ventilation became necessary. The lowest PaO2/FIO2 ratio was 77, and he was placed on extracorporeal membrane oxygenation (ECMO). Based on our observation, the emergency use of ECMO in addition to peramivir might be useful. A noteworthy point is that once ARDS deteriorates due to pandemic (H1N1) 2009, intensive supportive care should be started.

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“…Laboratory and clinical findings have implicated an immunologic pathophysiology of the disease (1). In approximately one half of the cases, the syndrome becomes manifest after chronic exposure to toxic drugs or chemicals (2)(3)(4)(5)(6). Aplastic anemia has also long been linked with toxic exposure to pesticide(s).…”

Section: Introductionmentioning

confidence: 99%

An Animal Model of Chronic Aplastic Bone Marrow Failure Following Pesticide Exposure in Mice

Chatterjee¹,

Chaklader²,

Basak³

et al. 2010

Int J Stem Cells

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The wide use of pesticides for agriculture, domestic and industrial purposes and evaluation of their subsequent effect is of major concern for public health. Human exposure to these contaminants especially bone marrow with its rapidly renewing cell population is one of the most sensitive tissues to these toxic agents represents a risk for the immune system leading to the onset of different pathologies. In this experimental protocol we have developed a mouse model of pesticide(s) induced hypoplastic/aplastic marrow failure to study quantitative changes in the bone marrow hematopoietic stem cell (BMHSC) population through flowcytometric analysis, defects in the stromal microenvironment through short term adherent cell colony (STACC) forming assay and immune functional capacity of the bone marrow derived cells through cell mediated immune (CMI) parameter study. A time course dependent analysis for consecutive 90 days were performed to monitor the associated changes in the marrow's physiology after 30 th , 60 th and 90 th days of chronic pesticide exposure.The peripheral blood showed maximum lowering of the blood cell count after 90 days which actually reflected the bone marrow scenario. Severe depression of BMHSC population, immune profile of the bone marrow derived cells and reduction of adherent cell colonies pointed towards an essentially empty and hypoplastic marrow condition that resembled the disease aplastic anemia. The changes were accompanied by splenomegaly and splenic erythroid hyperplasia. In conclusion, this animal model allowed us a better understanding of clinico-biological findings of the disease aplastic anemia following toxic exposure to the pesticide(s) used for agricultural and industrial purposes.

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Animal Models for Acquired Bone Marrow Failure Syndromes

Cited by 52 publications

References 45 publications

Life and Death of Cardiac Stem Cells

Life and Death of Cardiac Stem Cells

Pandemic (H1N1) 2009-Associated ARDS Rescued by Neuraminidase Inhibitors with Emergency Use of Extracorporeal Membrane Oxygenation

An Animal Model of Chronic Aplastic Bone Marrow Failure Following Pesticide Exposure in Mice

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