Animal model of radiogenic bone damage to study mandibular osteoradionecrosis

Cohen, Marc; Nishimura, Ichiro; Tamplen, Matthew; Hokugo, Akishige; Beumer, John; Steinberg, Michael L.; Suh, Jeffrey D.; Abemayor, Elliot; Nabili, Vishad

doi:10.1016/j.amjoto.2010.06.001

Cited by 38 publications

(68 citation statements)

References 16 publications

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“…It also was observed that alveolar socket healing was clearly delayed by ionizing radiation at 15 days after tooth extraction but not at 30 days, suggesting that it is more affected in the intermediate stage than in the final stage. In the study by Cohen et al (18), the numerical difference in bone volume fraction between the irradiated group and the control group at 28 days after tooth extraction was lower than the same difference at 21 days after tooth extraction in the study by Tamplen et al (14), although a higher radiation dose was used in the former study. Considering the disparities in the methodologies, this could support the idea that the final stage of the alveolar socket healing is less influenced by ionizing radiation.…”

Section: Discussionmentioning

confidence: 82%

“…Earlier studies were done to develop an induction model of osteoradionecrosis in animals by causing changes in bone physiology with ionizing radiation (12,(14)(15)(16)(17)(18); however, none of these studies focused at preventing its occurrence. In addition, although other studies evaluated the possible effects of radiation-protective agents on ionizing radiation damage(5-11), they tested the agents on acute complications and none correlated to delayed complications.…”

Section: Discussionmentioning

confidence: 99%

“…In order to simulate the situation in which a patient must have a tooth extracted sometime after radiotherapy, tooth extraction was performed on the animals, similar to others studies (14,18,20). However, unlike those studies, it was chosen to perform it 40 days after the animals received irradiation, a period sufficient to reveal histological changes in bone tissue in mandibles of irradiated rats (12), and because tooth extraction is contraindicated during treatment.…”

Section: Discussionmentioning

confidence: 99%

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Meloxicam as a Radiation-Protective Agent on Mandibles of Irradiated Rats

et al. 2017

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This study evaluated the action of ionizing radiation and the possible radioprotective effect of the non-steroidal anti-inflammatory drug meloxicam on the bone physiology of rat mandibles by assessing the alveolar socket healing and bone strength. Forty male Wistar rats were divided in 4 groups (n=10): control (CG), irradiated (IG), meloxicam (MG), meloxicam irradiated (MIG). A dose of 0.2 mg/kg meloxicam was administered to MG and MIG. After this, IG and MIG were irradiated with 15 Gy radiation dose in the mandible. Forty days after the above procedures, the mandibular first molars were extracted and the animals were killed after 15 or 30 days (n=5). Micro-computed tomography and bending test were used to evaluate alveolar socket healing and bone strength, respectively. At 15 days, bone volume, bone volume fraction and trabecular thickness were higher in the CG and MG than in the IG and MIG; and trabecular separation was higher in the IG compared with the others. At 30 days, there was a difference only in trabecular separation, which was higher in IG than in CG and MG, and MIG did not differ from the others. Bone strength was lower in IG compared with CG and MG, and MIG did not differ from the others. In conclusion, the ionizing radiation affected the bone physiology of rat mandibles, delaying the alveolar socket healing and reducing the bone strength. Moreover, the meloxicam had a positive effect on the trabecular separation in alveolar socket healing and on the bone strength.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Meloxicam as a Radiation-Protective Agent on Mandibles of Irradiated Rats

et al. 2017

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“…14 Group I animals received radiation at a dose of 25 Gy and group II received 28 Gy. According to the biological equivalent dose linear quadratic equation 15 (biological equivalent dose ϭ nd [1 ϩ d/{␣/␤}], where n represents the irradiation times, d the fractionated dose, and ␣/␤ approximates 3 in the bone tissues), the authors calculated that the single 25-and 28-Gy doses were equivalent to the conventional fractionated doses of 65 and 80 Gy, respectively, used in the clinical setting. 14 The irradiated area covered the mandibular teeth using 1-cm-step stereotactic radiotherapy.…”

Section: Establishment Of Ornm Modelsmentioning

confidence: 99%

Ultrasonic Treatment of Canine ORNM

Chen

et al. 2013

Journal of Oral and Maxillofacial Surgery

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“…Cohen et al [21] described a high-dose rate (HDR) brachytherapy model incorporating post-radiation dental extractions. They obtained reproducible radiographic mandibular bone damage analogous to clinical ORN.…”

Section: Radiation Therapymentioning

confidence: 99%

Osteoradionecrosis of the Jaws

Bagán

Scully

Zapater

et al. 2011

Clinic Rev Bone Miner Metab

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Osteoradionecrosis (ORN) is one of the most serious oral complications of head and neck cancer treatment with radiotherapy. There is bone tissue necrosis and failure to heal. The bone becomes devitalized and exposed through the overlying skin or mucosa, without healing for 3 months, without the recurrence of tumor. We review the etiological factors implicated in the ORN and describe the influence of infection, radiation therapy, dental status, and surgery. Finally, we present the currently accepted therapeutics procedures for the management of osteoradionecrosis.Keywords Osteoradionecrosis Á Jaws Á Bone necrosis Osteoradionecrosis (ORN) is one of the most serious oral complications of head and neck cancer treatment. It is characterized by a severe delayed radiation-induced injury, characterized by bone tissue necrosis and failure to heal [1-3], and several definitions have been proposed. One of the most widely accepted is that published by Harris [4]. He describes ORN as an irradiated bone that becomes devitalized and exposed through the overlying skin or mucosa, without healing for 3 months, without the recurrence of tumor. Marx [5] defined ORN as an area greater than 1 cm of exposed bone in a field of irradiation that had failed to show any evidence of healing for at least 6 months.Given the increased use of radiation therapy (RT) and combined chemotherapy-radiation therapy (CRT) regimens in the treatment of head and neck malignancies, it is anticipated that osteoradionecrosis will continue to be an important clinical problem [6], though newer radiotherapy techniques may reduce ORN to a degree, as discussed below.No studies to date have systematically addressed the impact of ORN on either quality of life or cost of care [7]. EpidemiologyIn a retrospective study of 830 patients with head and neck tumors who received radiotherapy between 1969 and 1999, there was an incidence of ORN of 8.2% and a threefold higher incidence in men than in women [8]. In contrast, Cheng et al. [9] in 2006 found the prevalence to be 2.7%.New cancer treatment strategies such as intensity-modulated RT (IMRT) and concomitant CRT have had disappointingly minimal effect on the prevalence of ORN. In a review of 43 articles published between 1990 and 2008, Peterson et al. [7] found that the weighted prevalence for ORN in conventional RT was 7.4%, for IMRT 5.1%, CRT 6.8%, and brachytherapy 5.3%. EtiologyThe cause and pathogenesis of osteoradionecrosis are far more complex than originally believed [6]. Recent theories for the pathogenesis of ORN have proposed that bone

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Animal model of radiogenic bone damage to study mandibular osteoradionecrosis

Cited by 38 publications

References 16 publications

Meloxicam as a Radiation-Protective Agent on Mandibles of Irradiated Rats

Meloxicam as a Radiation-Protective Agent on Mandibles of Irradiated Rats

Ultrasonic Treatment of Canine ORNM

Osteoradionecrosis of the Jaws

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