Animal Lectin

Narayanan, Sahya; Pallan, Akhila Raj; Balakrishnan, Akshay; Paul, Eldho J.; Elumalai, Preetham

doi:10.1007/978-981-16-7462-4_5

Cited by 2 publications

(2 citation statements)

References 54 publications

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“…They recognise nonself or altered self cells or molecules stimulating their clearance by phagocytosis or triggering an inflammatory response [ 33 ]. Among the many families of animal lectins [ 1 , 2 , 3 , 4 , 5 ], rhamnose-binding lectins form a family of proteins described in many animals, both vertebrates (fish) and invertebrates [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Animal lectins are characterised by different structures, carbohydrate specificities and physiological roles. Galectins, C-type lectins, P-type lectins, I-type lectins, fucolectins and pentraxins are some of the main families of animal lectins [ 1 , 2 , 3 , 4 , 5 ]. They modulate various physiological processes, such as cell–cell interactions during development and differentiation [ 1 , 6 ] or the recognition of nonself molecules by the immune system [ 5 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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New Data on the Rhamnose-Binding Lectin from the Colonial Ascidian Botryllus schlosseri: Subcellular Distribution, Secretion Mode and Effects on the Cyclical Generation Change

Bovo

Ballarin

2023

Marine Drugs

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Botryllus schlosseri in a cosmopolitan ascidian, considered a reliable model organism for studies on the evolution of the immune system. B. schlosseri rhamnose-binding lectin (BsRBL) is synthesised by circulating phagocytes and behaves as an opsonin by interacting with foreign cells or particles and acting as a molecular bridge between them and the phagocyte surface. Although described in previous works, many aspects and roles of this lectin in Botryllus biology remain unknown. Here, we studied the subcellular distribution of BsRBL during immune responses using light and electron microscopy. In addition, following the hints from extant data, suggesting a possible role of BsRBL in the process of cyclical generation change or takeover, we investigated the effects of interfering with this protein, by injecting a specific antibody in the colonial circulation, starting one day before the generation change. Results confirm the requirement of the lectin for a correct generation change and open new queries on the roles of this lectin in Botryllus biology.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

New Data on the Rhamnose-Binding Lectin from the Colonial Ascidian Botryllus schlosseri: Subcellular Distribution, Secretion Mode and Effects on the Cyclical Generation Change

Bovo

Ballarin

2023

Marine Drugs

View full text Add to dashboard Cite

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Galectin-3: A novel prognostic marker for myocardial infarction

Hasan Jasim,

Ali Lefta

2023

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Background: Coronary heart disease (CHD), known as coronary artery disease (CAD) or ischemic heart disease (IHD), results from the hindrance of blood transit to the muscle of the lipid heart and cholesterol in the inner wall of the heart. Because of atherosclerosis, CAD contains many types of disease: stable angina, unstable angina, myocardial infarction(MI), and sudden cardiac death. Percutaneous Coronary Intervention (PCI), known as angioplasty, is a nonsurgical operation performed using a catheter to cram either inflate a balloon in the narrowing place or stent (a very small and fin grid tube made of either plastic or metal of stainless steel). So, it is covered with medicine to prevent coronary artery blockage again), and to expand or open up the vessels in the heart's muscle that contains plaque buildup that causes stenosis. Galectin-3 (Gal-3) is a multifunctional protein that coordinates varied physiological and pathological processes in the body of humans. Gal–3 is located in many of the cells and types of tissue, and several functions can be described, such as macrophage migration promotion, proliferation of fibroblasts and synthesis of collagen. The best function of Gal–3 is its role as a preventer for acute and chronic inflammation. In the universe, it has been related to carcinoma and CVD. Gal–3 has been discovered in various types of cells, like stimulated macrophages, fibroblasts, dendritic cells, eosinophils, mast cells, chondrocytes and osteoblasts. Previous studies have shown that Gal–3 plays different functions in many tissues and plays its role in both intra and extracellular. Subjects: One hundred individuals were collected to contribute to the present study. These cases were divided into two groups. The first included 70 patients (their ages ranged between 30-66 years) with MI who underwent elective PCI and were divided into two subgroups: 30 patients with the first PCI and 40 patients who underwent more than one PCI. The second group involved 30 healthy individuals (aged 30-55 years) who were enrolled in the present study as a control group. Results: The results showed a significant increase (p=0.001) of serum Gal-3 levels in the patient's group compared to control individuals. Moreover, the result illustrated a statistically significant elevation in the Gal-3 levels (p=0.000) when comparing the two male subgroups (patients with one PCI and healthy). The same results were observed when the female subgroups were compared together. No significant differences were recorded when the two genders in the same group were compared (p=0.093 for one PCI patient and p=0.563 for healthy individuals). Keywords: CVD, CHD, PCI, Lectins, Gal-3

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Animal Lectin

Cited by 2 publications

References 54 publications

New Data on the Rhamnose-Binding Lectin from the Colonial Ascidian Botryllus schlosseri: Subcellular Distribution, Secretion Mode and Effects on the Cyclical Generation Change

New Data on the Rhamnose-Binding Lectin from the Colonial Ascidian Botryllus schlosseri: Subcellular Distribution, Secretion Mode and Effects on the Cyclical Generation Change

Galectin-3: A novel prognostic marker for myocardial infarction

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