Animal Experiments on the Spinal Action of Midazolam

The Use of Intrathecal Midazolam in Humans: A Case Study of Process

“…Published evaluations of IT midazolam safety are presented in Table 3. The first systematic safety evaluation was reported by Muller et al (18) and Gerlach et al (49) in cats, where bolus delivery of concentrations of 1.35 mg/mL was undertaken. Although little detail is provided, the authors indicated that this approach was without deleterious histological effects, and thus the study provided the safety data for their subsequent human investigations with IT midazolam infusions.…”