Animal Chlamydiae: A Concern for Human and Veterinary Medicine

Marti, H. R.; Jelocnik, Martina

doi:10.3390/pathogens11030364

Cited by 3 publications

(2 citation statements)

References 31 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chlamydia is a family of obligate intracellular Gram-negative bacteria with a unique biphasic life cycle in which a small extracellular infectious basic body (EB) and a metabolically active reticulum (RB) play a special role ( Cheong et al., 2019 ; Marti and Jelocnik, 2022 ). Taxonomically, Chlamydia belongs to the order Chlamydiales and the family Chlamydiaceae and are currently subdivided into more than 10 species ( Sachse et al., 2015 ; Zaręba-Marchewka et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Clinical identification and microbiota analysis of Chlamydia psittaci- and Chlamydia abortus- pneumonia by metagenomic next-generation sequencing

Xie

Qing

Cao³

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

IntroductionRecently, the incidence of chlamydial pneumonia caused by rare pathogens such as C. psittaci or C. abortus has shown a significant upward trend. The non-specific clinical manifestations and the limitations of traditional pathogen identification methods determine that chlamydial pneumonia is likely to be poorly diagnosed or even misdiagnosed, and may further result in delayed treatment or unnecessary antibiotic use. mNGS's non-preference and high sensitivity give us the opportunity to obtain more sensitive detection results than traditional methods for rare pathogens such as C. psittaci or C. abortus. MethodsIn the present study, we investigated both the pathogenic profile characteristics and the lower respiratory tract microbiota of pneumonia patients with different chlamydial infection patterns using mNGS.ResultsMore co-infecting pathogens were found to be detectable in clinical samples from patients infected with C. psittaci compared to C. abortus, suggesting that patients infected with C. psittaci may have a higher risk of mixed infection, which in turn leads to more severe clinical symptoms and a longer disease course cycle. Further, we also used mNGS data to analyze for the first time the characteristic differences in the lower respiratory tract microbiota of patients with and without chlamydial pneumonia, the impact of the pattern of Chlamydia infection on the lower respiratory tract microbiota, and the clinical relevance of these characteristics. Significantly different profiles of lower respiratory tract microbiota and microecological diversity were found among different clinical subgroups, and in particular, mixed infections with C. psittaci and C. abortus resulted in lower lung microbiota diversity, suggesting that chlamydial infections shape the unique lung microbiota pathology, while mixed infections with different Chlamydia may have important effects on the composition and diversity of the lung microbiota. DiscussionThe present study provides possible evidences supporting the close correlation between chlamydial infection, altered microbial diversity in patients' lungs and clinical parameters associated with infection or inflammation in patients, which also provides a new research direction to better understand the pathogenic mechanisms of pulmonary infections caused by Chlamydia.

show abstract

Section: Introductionmentioning

confidence: 99%

Clinical identification and microbiota analysis of Chlamydia psittaci- and Chlamydia abortus- pneumonia by metagenomic next-generation sequencing

Xie

Qing

Cao³

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Avian chlamydiosis, commonly named ornithosis or psittacosis (Ciftci et (Maluping et al, 2007). There are many records of its zoonotic condition (Smith et Marti and Jelocnik, 2022). The agent can be found on bird feathers, in excrement and blood, in animals presenting or not presenting clinical signs of disease (Fenga et al, 2008; Geigenfeind and Haag-Wackernagel 2010; Chereau et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Serological evidence of Chlamydia psittaci in psittacines in three zoological parks in Portugal

Morais

Pires²,

Dorrestein³

et al. 2022

Vet. stn. (Online)

View full text Add to dashboard Cite

Chlamydia psittaci is an agent that causes ornithosis or psittacosis, which can infect homing and wild birds, mammalian animals and humans. Since this disease is an important zoonosis that is fatal and distributed worldwide, it is important to know its occurrence. This study aimed to survey the seropositivity of Chlamydia psittaci in three psittacine collections in three zoos in Portugal. In this study, 112 blood samples of the psittacine belonging to Order Psitaciformes (encompassing 31 species from 14 genera) were used. These samples were tested using a commercial ELISA kit (Immunocomb®, Biogal). The serological examination of psittacine samples using ELISA showed that 54 were positive (48.2%; 95% confidence interval, CI: 39.0-57.4%). The genus Ara exhibited significantly higher seropositivity than other genera (P<0.05). Based on the serological data from this study, we demonstrate that antibodies against Chlamydia psittaci are circulating in the blood of these tested animals. Since psittacosis is a public health concern, zoonotic issues of these results should be considered.

show abstract

Outbreak of Chlamydia psittaci Infection in a Commercial Psittacine Breeding Aviary in Argentina

Riccio,

García,

Chiapparrone

et al. 2024

Animals

View full text Add to dashboard Cite

Chlamydiosis, caused by Chlamydia psittaci is a bacterial infection found in at least 465 species of birds worldwide. It is highly contagious among birds and can spread to humans. In birds, the disease can manifest itself in acute, subacute, and chronic forms with signs including anorexia, diarrhea, lethargy, weight loss, or, occasionally, mucopurulent or serous oculonasal discharge. This article describes an outbreak of chlamydiosis that occurred in a commercial psittacine breeding aviary in 2021 in Buenos Aires province, Argentina. In total, 16 juvenile blue-fronted parrots, more than 60 blue-fronted parrot chicks, and 2 adult macaws died during the outbreak. In all cases, clinical signs were weight loss, diarrhea, yellowish green excrement, and respiratory distress. The necropsy of four juvenile blue-fronted parrots, two blue-fronted parrot chicks, and two adult macaws revealed cachexia, hepatomegaly, splenomegaly, splenic petechial hemorrhages, ascites, pulmonary edema, and hydropericardium. Histologically, multifocal lymphoplasmacytic and heterophilic airsaculitis, multifocal lymphoplasmacytic and necrotizing hepatitis with intracytoplasmic elementary bodies, multifocal necro-heterophilic hepatitis, multifocal lymphoplasmacytic nephritis, and diffuse heterophilic pneumonia were found. A presumptive diagnosis was established based on gross and microscopic lesions, and it was confirmed using immunohistochemistry and polymerase chain reactions. The sequencing and phylogenetic analysis of the ompA gene revealed genotype A and B of Chlamydia psittaci.

show abstract

Animal Chlamydiae: A Concern for Human and Veterinary Medicine

Abstract: The Chlamydiae are a phylum of obligate intracellular, Gram-negative bacteria with a biphasic lifecycle [...]

Cited by 3 publications

References 31 publications

Clinical identification and microbiota analysis of Chlamydia psittaci- and Chlamydia abortus- pneumonia by metagenomic next-generation sequencing

Clinical identification and microbiota analysis of Chlamydia psittaci- and Chlamydia abortus- pneumonia by metagenomic next-generation sequencing

Serological evidence of Chlamydia psittaci in psittacines in three zoological parks in Portugal

Outbreak of Chlamydia psittaci Infection in a Commercial Psittacine Breeding Aviary in Argentina

Contact Info

Product

Resources

About