Animal Accommodation

Inglis, J.K.

doi:10.1016/b978-0-08-023772-5.50008-7

Cited by 2 publications

(2 citation statements)

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“…Our results show that male guinea pigs can be divided into two age categories before 50 weeks old: the growing process until 10 weeks and the period of maturity after 10 weeks. This is in agreement with the previous observation that the age of maturation in male guinea pigs is 10 weeks (26). It was also supported by the ALP activity, which is known to be relatively low in the period of maturity.…”

Section: Discussionsupporting

confidence: 81%

Age-Related Changes in the Pyridinoline Content of Guinea Pigs Cartilage and Achilles Tendon Collagen.

Kim

Otsuka

Arakawa

1994

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryAge-related changes of pyridinoline, a mature cross-link of collagen fibers, in tissues of guinea pigs which cannot synthesize L ascorbic acid (AsA) were investigated. Male guinea pigs, 2 weeks old, were fed a commercial diet unitil they were 40 weeks old. Based on the data of body weight gain, it is assumed that guinea pigs require 10 weeks to reach maturity. The content of AsA in serum, adrenals, and liver of the animals increased with growth, then decreased after 8-10 weeks. The pyridinoline content in cartilage and tendon collagen was very low in 2 week-old animals, whereas it increased markedly with growth. After 10 weeks, the pyridinoline tended to decrease in cartilage collagen; however, it was not changed in tendon collagen. The age-related changes of pyridinoline content in guinea pigs cartilage were similar to those of humans-increasing with growth and decreasing after adolescence.

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Section: Discussionsupporting

confidence: 81%

Age-Related Changes in the Pyridinoline Content of Guinea Pigs Cartilage and Achilles Tendon Collagen.

Kim

Otsuka

Arakawa

1994

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Adult male albino rats of the Sprague–Dawley strain weighing 180–220 g were maintained under standard laboratory conditions in clean polypropylene cages (two animals per cage) under 12 h of light/dark cycle at 25 ± 2°C, with food (rat chow; Hindustan Lever Ltd, Bombay, India) and water provided ad libitum (Inglis, 1980). Animals were acclimated for about a week prior to use.…”

Section: Methodsmentioning

confidence: 99%

Low concentration of mercury induces autophagic cell death in rat hepatocytes

et al. 2012

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In the present study, we attempted to elucidate the induction of autophagy in rat hepatocytes by a low concentration of mercury. Hepatocytes treated with different doses of mercuric chloride (HgCl2; 1, 2.5, 5 and 10 µM) and at different time intervals (0 min, 30 min, 1 h, 2 h and 4 h) show autophagic cell death only at 5 µM HgCl2 within 30 min of incubation. At 1 and 2.5 µM HgCl2, no cell death is recorded, while apoptosis is found at 10 µM HgCl2, as evidenced by the activation of caspase 3. Autophagic cell death is confirmed by the presence of monodansylcadaverine (MDC) positive hepatocytes which is found to be highest at 1 h. Atg5-Atg12 covalent-conjugation triggers the autophagic pathway within 30 min of 5 µM HgCl2 treatment and continues till 4 h of incubation. In addition, damage-regulated autophagy modulator (DRAM) expression gradually increases from 30 min to 4 h of treatment with mercury and a corresponding linear decrease in p53 has been observed. It is concluded that a low concentration (5 µM HgCl2) of mercury induces autophagy or nonapoptotic programmed cell death following an Atg5-Atg12 covalent-conjugation pathway, which is modulated by DRAM in a p53-dependent manner.

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Animal Accommodation

Cited by 2 publications

References 0 publications

Age-Related Changes in the Pyridinoline Content of Guinea Pigs Cartilage and Achilles Tendon Collagen.

Age-Related Changes in the Pyridinoline Content of Guinea Pigs Cartilage and Achilles Tendon Collagen.

Low concentration of mercury induces autophagic cell death in rat hepatocytes

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