Anhydroecgonine methyl ester (AEME), a cocaine pyrolysis product, impairs glutathione-related enzymes response and increases lipid peroxidation in the hippocampal cell culture

Abstract

HighlightsAEME and cocaine decreased GPx, GR and GST activities after 3 and 6 h of exposure.AEME and cocaine increased MDA after 48 h of exposure.AEME-cocaine combination decreased GPx, GR and GST activities after 3 and 6 h.AEME-cocaine combination showed an additive effect on MDA after 48 h of exposure.A higher neurotoxic effect after crack cocaine use is suggested.